FR2394544A1 - Procede de reduction stereospecifique de la quinidinone en quinidine - Google Patents

Procede de reduction stereospecifique de la quinidinone en quinidine

Info

Publication number
FR2394544A1
FR2394544A1 FR7718397A FR7718397A FR2394544A1 FR 2394544 A1 FR2394544 A1 FR 2394544A1 FR 7718397 A FR7718397 A FR 7718397A FR 7718397 A FR7718397 A FR 7718397A FR 2394544 A1 FR2394544 A1 FR 2394544A1
Authority
FR
France
Prior art keywords
redn
oxidn
quinine
esp
quinidinone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
FR7718397A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
DEVINTER SA
Original Assignee
DEVINTER SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by DEVINTER SA filed Critical DEVINTER SA
Priority to FR7718397A priority Critical patent/FR2394544A1/fr
Priority to US05/915,010 priority patent/US4174449A/en
Priority to DE7878400020T priority patent/DE2860188D1/de
Priority to EP19780400020 priority patent/EP0000302B1/fr
Priority to IT7868393A priority patent/IT7868393A0/it
Priority to IE120378A priority patent/IE46996B1/en
Publication of FR2394544A1 publication Critical patent/FR2394544A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • C07D453/04—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems having a quinolyl-4, a substituted quinolyl-4 or a alkylenedioxy-quinolyl-4 radical linked through only one carbon atom, attached in position 2, e.g. quinine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La présente invention se rapporte à un procédé de réduction stéréospécifique de la quinidinone en quinidine. L'agent réducteur employé est un hydrure d'un alkyl aluminium, ou d'un compose analogue plus complexe comportant l'aluminium et un métal alcalin, qui est utilisé en présence d'un agent orienteur constitué par une base organique contenant un hétérocycle azoté. On peut utiliser un solvant auxiliaire par exemple de type aromatique ou éther pour diluer le milieu et/ou introduire l'agent réducteur. L'application de cette invention est l'obtention de la quinidine à partir de son dérivé d'oxydation, la quinidinone.
FR7718397A 1977-06-15 1977-06-15 Procede de reduction stereospecifique de la quinidinone en quinidine Withdrawn FR2394544A1 (fr)

Priority Applications (6)

Application Number Priority Date Filing Date Title
FR7718397A FR2394544A1 (fr) 1977-06-15 1977-06-15 Procede de reduction stereospecifique de la quinidinone en quinidine
US05/915,010 US4174449A (en) 1977-06-15 1978-06-13 Process for the reduction of quinidinone to quinidine
DE7878400020T DE2860188D1 (en) 1977-06-15 1978-06-14 Novel method for the preparation of quinidine.
EP19780400020 EP0000302B1 (fr) 1977-06-15 1978-06-14 Nouveau procédé de préparation de la quinidine.
IT7868393A IT7868393A0 (it) 1977-06-15 1978-06-15 Procedimento per la preparazione della chinidina
IE120378A IE46996B1 (en) 1977-06-15 1978-06-15 Process for the preparation of quinidine

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7718397A FR2394544A1 (fr) 1977-06-15 1977-06-15 Procede de reduction stereospecifique de la quinidinone en quinidine

Publications (1)

Publication Number Publication Date
FR2394544A1 true FR2394544A1 (fr) 1979-01-12

Family

ID=9192139

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7718397A Withdrawn FR2394544A1 (fr) 1977-06-15 1977-06-15 Procede de reduction stereospecifique de la quinidinone en quinidine

Country Status (2)

Country Link
FR (1) FR2394544A1 (fr)
IT (1) IT7868393A0 (fr)

Also Published As

Publication number Publication date
IT7868393A0 (it) 1978-06-15

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Legal Events

Date Code Title Description
ST Notification of lapse