FR2392987A1 - TETRA-NICOTINIC ESTER OF PAPAVEROLINE AND PROCESS FOR OBTAINING THIS ACTIVE PRODUCT AGAINST CIRCULATORY DISORDERS - Google Patents

TETRA-NICOTINIC ESTER OF PAPAVEROLINE AND PROCESS FOR OBTAINING THIS ACTIVE PRODUCT AGAINST CIRCULATORY DISORDERS

Info

Publication number
FR2392987A1
FR2392987A1 FR7816137A FR7816137A FR2392987A1 FR 2392987 A1 FR2392987 A1 FR 2392987A1 FR 7816137 A FR7816137 A FR 7816137A FR 7816137 A FR7816137 A FR 7816137A FR 2392987 A1 FR2392987 A1 FR 2392987A1
Authority
FR
France
Prior art keywords
papaveroline
tetra
obtaining
active product
circulatory disorders
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7816137A
Other languages
French (fr)
Other versions
FR2392987B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SCHARPER SpA
Original Assignee
SCHARPER SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SCHARPER SpA filed Critical SCHARPER SpA
Publication of FR2392987A1 publication Critical patent/FR2392987A1/en
Application granted granted Critical
Publication of FR2392987B1 publication Critical patent/FR2392987B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Vascular Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

a. L'invention concerne un dérivé de la papavéroline ainsi qu'un procédé pour la préparation de ce produit. b. Ce produit est l'ester tétranicotinique de la papavéroline que l'on obtient en faisant réagir le chlorhydrate de chlorure de nicotyl avec la papavéroline à une température de 20 à 30 degrés C, puis on sépare le produit du mélange réactionnel. c. Ce produit présente l'avantage de présenter une efficacité de plus longue durée après l'administration grâce à un effet << retard >> net.at. The invention relates to a papaverolin derivative and to a process for the preparation thereof. b. This product is the tetranicotinic ester of papaveroline which is obtained by reacting nicotyl chloride hydrochloride with papaveroline at a temperature of 20 to 30 degrees C, then the product is separated from the reaction mixture. vs. This product has the advantage of exhibiting longer lasting efficacy after administration due to a clear "delay" effect.

FR7816137A 1977-05-30 1978-05-30 TETRA-NICOTINIC ESTER OF PAPAVEROLINE AND PROCESS FOR OBTAINING THIS ACTIVE PRODUCT AGAINST CIRCULATORY DISORDERS Granted FR2392987A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT24141/77A IT1143667B (en) 1977-05-30 1977-05-30 PARAVEROLINIC DERIVATIVE WITH A DURABLE ACTION AND PROCEDURE TO OBTAIN IT

Publications (2)

Publication Number Publication Date
FR2392987A1 true FR2392987A1 (en) 1978-12-29
FR2392987B1 FR2392987B1 (en) 1982-04-23

Family

ID=11212187

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7816137A Granted FR2392987A1 (en) 1977-05-30 1978-05-30 TETRA-NICOTINIC ESTER OF PAPAVEROLINE AND PROCESS FOR OBTAINING THIS ACTIVE PRODUCT AGAINST CIRCULATORY DISORDERS

Country Status (13)

Country Link
JP (1) JPS53149982A (en)
BE (1) BE867515A (en)
BR (1) BR7803416A (en)
CA (1) CA1084504A (en)
CH (1) CH633446A5 (en)
DE (1) DE2822186A1 (en)
ES (1) ES470343A1 (en)
FR (1) FR2392987A1 (en)
GB (1) GB1593598A (en)
GR (1) GR63731B (en)
IT (1) IT1143667B (en)
MX (1) MX5515E (en)
PT (1) PT68115A (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA803993B (en) * 1979-07-19 1981-07-29 Buzas Andre New isoquinoline derivatives and preparation thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR794M (en) * 1960-12-02 1961-09-11

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1175246B (en) * 1959-12-14 1964-08-06 Orsymonde Fa Process for the preparation of dimethylpapa-verolin-bis-nicotinic acid ester and its acidic dimaleate

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR794M (en) * 1960-12-02 1961-09-11

Also Published As

Publication number Publication date
MX5515E (en) 1983-09-14
FR2392987B1 (en) 1982-04-23
GB1593598A (en) 1981-07-22
CH633446A5 (en) 1982-12-15
JPS53149982A (en) 1978-12-27
PT68115A (en) 1978-06-01
GR63731B (en) 1979-12-04
BE867515A (en) 1978-09-18
CA1084504A (en) 1980-08-26
DE2822186A1 (en) 1978-12-14
ES470343A1 (en) 1979-01-01
BR7803416A (en) 1979-01-02
JPS572715B2 (en) 1982-01-18
IT1143667B (en) 1986-10-22

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