FR2392004A1 - 3-Thia-13-trans-prostenoic acid derivs. - useful as selective and long lasting hypotensives, antisecretories, antiulcer agents, contraceptives, CNS regulators, abortifacients, etc. - Google Patents

3-Thia-13-trans-prostenoic acid derivs. - useful as selective and long lasting hypotensives, antisecretories, antiulcer agents, contraceptives, CNS regulators, abortifacients, etc.

Info

Publication number
FR2392004A1
FR2392004A1 FR7809305A FR7809305A FR2392004A1 FR 2392004 A1 FR2392004 A1 FR 2392004A1 FR 7809305 A FR7809305 A FR 7809305A FR 7809305 A FR7809305 A FR 7809305A FR 2392004 A1 FR2392004 A1 FR 2392004A1
Authority
FR
France
Prior art keywords
regulators
antisecretories
abortifacients
hypotensives
contraceptives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
FR7809305A
Other languages
French (fr)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth Holdings LLC
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Publication of FR2392004A1 publication Critical patent/FR2392004A1/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/40—Radicals substituted by oxygen atoms
    • C07D307/42—Singly bound oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C31/00—Saturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C31/13—Monohydroxylic alcohols containing saturated rings
    • C07C31/133—Monohydroxylic alcohols containing saturated rings monocyclic
    • C07C31/1336—Monohydroxylic alcohols containing saturated rings monocyclic with a four-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
    • C07C405/0033—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing sulfur
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/12—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/16—Radicals substituted by halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F3/00—Compounds containing elements of Groups 2 or 12 of the Periodic Table
    • C07F3/02—Magnesium compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/027—Organoboranes and organoborohydrides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0803—Compounds with Si-C or Si-Si linkages
    • C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
    • C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/22—Tin compounds
    • C07F7/2208—Compounds having tin linked only to carbon, hydrogen and/or halogen

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrane Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Optically active prostaglandin analogues of formula (I), their racemates, mirror images and, when R1 is OH, pharmaceutically acceptable salts, are new. In the formula, n is 3 or 4. R1 is OH or 1-6C alkoxy W is one of the gps. (II)- Q is e.g. -C(CH3)2R6, -CH2C(CH3)2R7 or -CHR6R8; R4 is H or CH3; R5 is 4-7C alkyl; R6 is 3-5C alkyl; R7 is 2-4C alkyl; R8 is 1-2C alkyl. (I) are useful as hypotensives, antiulcer agents, antisecretories, to protect against gastric damage by nonsteroid antiinflammatories, abortifacients, labour- or menstruation-inducers, contraceptives, regulators of oestrus (in animal breeding) and CNS regulators Generally compared with natural PG's they are more selective and/or have a more persistent effect.
FR7809305A 1977-03-30 1978-03-30 3-Thia-13-trans-prostenoic acid derivs. - useful as selective and long lasting hypotensives, antisecretories, antiulcer agents, contraceptives, CNS regulators, abortifacients, etc. Withdrawn FR2392004A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US78285477A 1977-03-30 1977-03-30
US78279777A 1977-03-30 1977-03-30
US78285677A 1977-03-30 1977-03-30

Publications (1)

Publication Number Publication Date
FR2392004A1 true FR2392004A1 (en) 1978-12-22

Family

ID=27419787

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7809305A Withdrawn FR2392004A1 (en) 1977-03-30 1978-03-30 3-Thia-13-trans-prostenoic acid derivs. - useful as selective and long lasting hypotensives, antisecretories, antiulcer agents, contraceptives, CNS regulators, abortifacients, etc.

Country Status (5)

Country Link
JP (1) JPS5481241A (en)
BE (1) BE865497A (en)
DE (1) DE2813305A1 (en)
FR (1) FR2392004A1 (en)
NL (1) NL7803420A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0051284A1 (en) * 1980-10-31 1982-05-12 Teijin Limited Novel thiaprostaglandin E1 derivatives, process for production thereof, and pharmaceuticals containing these compounds

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6092255A (en) * 1983-10-26 1985-05-23 Sumitomo Chem Co Ltd Novel bicyclooctane derivative and its preparation
JP3579448B2 (en) * 1993-12-29 2004-10-20 大正製薬株式会社 Prostaglandin derivatives, salts thereof and uses thereof

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0051284A1 (en) * 1980-10-31 1982-05-12 Teijin Limited Novel thiaprostaglandin E1 derivatives, process for production thereof, and pharmaceuticals containing these compounds

Also Published As

Publication number Publication date
DE2813305A1 (en) 1978-10-12
BE865497A (en) 1978-10-02
JPS5481241A (en) 1979-06-28
NL7803420A (en) 1978-10-03

Similar Documents

Publication Publication Date Title
GEP19960412B (en) Insecticide composition
ES513108A0 (en) "PREPARATION PROCEDURE FOR 1-PHENYL-1-HYDROXY-ETHYLAMINE DERIVATIVES".
ATE19878T1 (en) BENZIMIDAZOLE DERIVATIVES, PROCESS FOR THEIR MANUFACTURE AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
GB1438311A (en) Chloroacetanilides for regulating plant growth
GB1459571A (en) Thiophene-2-sulphonamide derivatives and their use as therapeutic agents sheet orienting apparatus
ATE27956T1 (en) CEPHALOSPORIN COMPOUNDS AND PROCESSES FOR THEIR PRODUCTION.
FI873413A0 (en) PHENOXYETXYRADERIVES OCH DERAS FRAMSTAELLNING.
ATE2622T1 (en) 2-LOWER GALKYL-7-SUBSTITUTED-2 OR 3-CEPHEM-4-CARBONIC ACIDS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
FR2392004A1 (en) 3-Thia-13-trans-prostenoic acid derivs. - useful as selective and long lasting hypotensives, antisecretories, antiulcer agents, contraceptives, CNS regulators, abortifacients, etc.
IE44627L (en) m-TRIFLUOROMETHYLPHENYL-PIPERIDINES.
ES461785A1 (en) Behenic acid esters, compositions thereof and a method of preparation thereof
ES480603A1 (en) Indole derivatives, their preparation and use in pharmaceutical compositions.
ATE153500T1 (en) METHOD FOR INHIBITING FIBROSIS
GB1269851A (en) Sweetened compositions
SE8103107L (en) PROCEDURE FOR THE PREPARATION OF 4A-ARYL-OCTAHYDRO-1H-2-PYRINDINES
SE7910390L (en) ANTIBACTERIAL AGENTS
ES8103056A1 (en) Prostaglandin analogue imidazole derivatives, processes for their preparation and a pharmaceutical composition containing them.
ES481198A1 (en) 155deoxyy166hydroxyy166substitutedd prostanate and homologue thereof
SE8001981L (en) COMPOSITIONS FOR TREATMENT OF GLAUCOM
BG29862A3 (en) Corrosion inhibited herbicide composition
FI791904A (en) FRAMEWORK FOR KETONHYDANTOINPROSTAGLANDINANALOGER
ES455043A1 (en) 5-Alkylureido-1,3,4-thiadiazol-2-yl-sulfonyl-acetic acid derivatives
EP0210772A3 (en) 3-û(4-aroyl)phenoxy(or phenylthio)¨cyclopentanecarboxylic acid analogues
IE791648L (en) Basically substituted urea compounds
BG28558A3 (en) FUNGICIDAL COMPOSITION

Legal Events

Date Code Title Description
ST Notification of lapse