FI791904A - FRAMEWORK FOR KETONHYDANTOINPROSTAGLANDINANALOGER - Google Patents

FRAMEWORK FOR KETONHYDANTOINPROSTAGLANDINANALOGER

Info

Publication number
FI791904A
FI791904A FI791904A FI791904A FI791904A FI 791904 A FI791904 A FI 791904A FI 791904 A FI791904 A FI 791904A FI 791904 A FI791904 A FI 791904A FI 791904 A FI791904 A FI 791904A
Authority
FI
Finland
Prior art keywords
sub
alkyl
cycloalkyl
ketonhydantoinprostaglandinanaloger
framework
Prior art date
Application number
FI791904A
Other languages
Finnish (fi)
Inventor
Frederick Cassidy
Alexander Crossan Goudie
Original Assignee
Beecham Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Group Ltd filed Critical Beecham Group Ltd
Publication of FI791904A publication Critical patent/FI791904A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/86—Oxygen and sulfur atoms, e.g. thiohydantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/673—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by change of size of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/30—Oxygen or sulfur atoms
    • C07D233/32—One oxygen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/72—Two oxygen atoms, e.g. hydantoin
    • C07D233/76—Two oxygen atoms, e.g. hydantoin with substituted hydrocarbon radicals attached to the third ring carbon atom

Abstract

A compound of the formula (I):wherein:X is O, S or H<sub>2</sub>;Yis-CH<sub>2</sub>-CH<sub>2</sub> -CH = CH- or C≡C-;n is 1 to 7;R, is C<sub>1-4</sub>alkyl;R<sub>3</sub> is hydroxy or protected hydroxy;R<sub>4</sub> is C<sub>1-9</sub> alkyl, C<sub>3</sub>-<sub>8</sub> cycloalkyl or C<sub>3-8</sub> cycloalkyl-C<sub>1-6</sub> alkyl; orR<sub>2</sub> and R<sub>4</sub> taken with the carbon atom to which they are joined represent a C<sub>5-8</sub> cycloalkyl group; and R<sub>5</sub> is hydrogen or C<sub>1-6</sub> alkyl; and salts thereof have useful pharmaceutical activity including bronchodilator activity. A method for the preparation is given.
FI791904A 1978-06-15 1979-06-14 FRAMEWORK FOR KETONHYDANTOINPROSTAGLANDINANALOGER FI791904A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB7827019 1978-06-15

Publications (1)

Publication Number Publication Date
FI791904A true FI791904A (en) 1979-12-16

Family

ID=10497983

Family Applications (1)

Application Number Title Priority Date Filing Date
FI791904A FI791904A (en) 1978-06-15 1979-06-14 FRAMEWORK FOR KETONHYDANTOINPROSTAGLANDINANALOGER

Country Status (13)

Country Link
US (1) US4241074A (en)
EP (1) EP0006353B1 (en)
JP (1) JPS554388A (en)
AT (1) ATE1422T1 (en)
AU (1) AU4778279A (en)
DE (1) DE2963476D1 (en)
DK (1) DK249479A (en)
ES (1) ES481603A1 (en)
FI (1) FI791904A (en)
IL (1) IL57505A0 (en)
NO (1) NO791979L (en)
PT (1) PT69750A (en)
ZA (1) ZA792977B (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA802765B (en) * 1979-05-23 1981-05-27 Beecham Group Ltd Novel compounds
US4496577A (en) * 1983-10-05 1985-01-29 Syntex (U.S.A.) Inc. Imidazolidinone prostaglandins, compositions and use
GB8417863D0 (en) * 1984-07-13 1984-08-15 Lucas Ind Plc Fuel pumping apparatus
US4746755A (en) * 1986-05-06 1988-05-24 The Dow Chemical Company Preparation of hydrantoic acids and hydantoins

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2323193A1 (en) * 1972-05-10 1973-11-22 Du Pont PYRAZOLIDINONE
DE2451160A1 (en) * 1973-10-30 1975-05-07 Du Pont 3-PYRAZOLIDINONE AND PYRAZOLIDINE
FI71930C (en) * 1976-06-03 1987-03-09 Wellcome Found Process for the preparation of 1,5-disubstituted hydantoin with aggregation of blood cells preventing action.
IL53559A0 (en) * 1976-12-18 1978-03-10 Beecham Group Ltd Novel prostaglandin analogues their preparation and pharmaceutical compositions containing them
US4147796A (en) * 1976-12-18 1979-04-03 Beecham Group Limited 1-(3-Hydroxyalk-1-yl)-5-(carboxyalkyl)hydantoin derivatives
GB1598073A (en) * 1976-12-18 1981-09-16 Beecham Group Ltd 8,10,12-triazaprostaglandins
AU527959B2 (en) * 1977-09-05 1983-03-31 Wellcome Foundation Limited, The Hydantoin derivatives

Also Published As

Publication number Publication date
NO791979L (en) 1979-12-18
DE2963476D1 (en) 1982-09-30
ATE1422T1 (en) 1982-08-15
IL57505A0 (en) 1979-10-31
JPS554388A (en) 1980-01-12
ZA792977B (en) 1980-06-25
US4241074A (en) 1980-12-23
PT69750A (en) 1979-07-01
DK249479A (en) 1979-12-16
AU4778279A (en) 1979-12-20
EP0006353A1 (en) 1980-01-09
EP0006353B1 (en) 1982-08-04
ES481603A1 (en) 1980-06-16

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Legal Events

Date Code Title Description
FD Application lapsed

Owner name: BEECHAM GROUP LIMITED