FR2390163A1 - Medicament et composition a base de reserpate de methyle pour le traitement de l'hypertension - Google Patents
Medicament et composition a base de reserpate de methyle pour le traitement de l'hypertensionInfo
- Publication number
- FR2390163A1 FR2390163A1 FR7813691A FR7813691A FR2390163A1 FR 2390163 A1 FR2390163 A1 FR 2390163A1 FR 7813691 A FR7813691 A FR 7813691A FR 7813691 A FR7813691 A FR 7813691A FR 2390163 A1 FR2390163 A1 FR 2390163A1
- Authority
- FR
- France
- Prior art keywords
- hypertension
- treatment
- composition based
- medicinal product
- methyl reserpate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 206010020772 Hypertension Diseases 0.000 title abstract 3
- MDJQWFFIUHUJSB-UQVJXISSSA-N Methyl reserpate Chemical compound COC1=CC=C2C(CCN3C[C@H]4C[C@@H](O)[C@@H]([C@H]([C@H]4C[C@@H]33)C(=O)OC)OC)=C3NC2=C1 MDJQWFFIUHUJSB-UQVJXISSSA-N 0.000 title abstract 3
- MDJQWFFIUHUJSB-MIESRMKVSA-N Methyl reserpate Natural products O=C(OC)[C@@H]1[C@@H](OC)[C@H](O)C[C@H]2[C@H]1C[C@H]1N(C2)CCc2c3c([nH]c12)cc(OC)cc3 MDJQWFFIUHUJSB-MIESRMKVSA-N 0.000 title abstract 3
- MDJQWFFIUHUJSB-UHFFFAOYSA-N Reserpinsaeure-methylester Natural products COC1=CC=C2C(CCN3CC4CC(O)C(C(C4CC33)C(=O)OC)OC)=C3NC2=C1 MDJQWFFIUHUJSB-UHFFFAOYSA-N 0.000 title abstract 3
- 229940126601 medicinal product Drugs 0.000 title 1
- 239000003814 drug Substances 0.000 abstract 3
- 229940079593 drug Drugs 0.000 abstract 2
- DNXIKVLOVZVMQF-UHFFFAOYSA-N (3beta,16beta,17alpha,18beta,20alpha)-17-hydroxy-11-methoxy-18-[(3,4,5-trimethoxybenzoyl)oxy]-yohimban-16-carboxylic acid, methyl ester Natural products C1C2CN3CCC(C4=CC=C(OC)C=C4N4)=C4C3CC2C(C(=O)OC)C(O)C1OC(=O)C1=CC(OC)=C(OC)C(OC)=C1 DNXIKVLOVZVMQF-UHFFFAOYSA-N 0.000 abstract 1
- 206010067482 No adverse event Diseases 0.000 abstract 1
- 241000208332 Rauvolfia Species 0.000 abstract 1
- LCQMZZCPPSWADO-UHFFFAOYSA-N Reserpilin Natural products COC(=O)C1COCC2CN3CCc4c([nH]c5cc(OC)c(OC)cc45)C3CC12 LCQMZZCPPSWADO-UHFFFAOYSA-N 0.000 abstract 1
- QEVHRUUCFGRFIF-SFWBKIHZSA-N Reserpine Natural products O=C(OC)[C@@H]1[C@H](OC)[C@H](OC(=O)c2cc(OC)c(OC)c(OC)c2)C[C@H]2[C@@H]1C[C@H]1N(C2)CCc2c3c([nH]c12)cc(OC)cc3 QEVHRUUCFGRFIF-SFWBKIHZSA-N 0.000 abstract 1
- 229930013930 alkaloid Natural products 0.000 abstract 1
- 150000003797 alkaloid derivatives Chemical class 0.000 abstract 1
- 210000003169 central nervous system Anatomy 0.000 abstract 1
- BJOIZNZVOZKDIG-MDEJGZGSSA-N reserpine Chemical compound O([C@H]1[C@@H]([C@H]([C@H]2C[C@@H]3C4=C([C]5C=CC(OC)=CC5=N4)CCN3C[C@H]2C1)C(=O)OC)OC)C(=O)C1=CC(OC)=C(OC)C(OC)=C1 BJOIZNZVOZKDIG-MDEJGZGSSA-N 0.000 abstract 1
- 229960003147 reserpine Drugs 0.000 abstract 1
- MDMGHDFNKNZPAU-UHFFFAOYSA-N roserpine Natural products C1C2CN3CCC(C4=CC=C(OC)C=C4N4)=C4C3CC2C(OC(C)=O)C(OC)C1OC(=O)C1=CC(OC)=C(OC)C(OC)=C1 MDMGHDFNKNZPAU-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D459/00—Heterocyclic compounds containing benz [g] indolo [2, 3-a] quinolizine ring systems, e.g. yohimbine; 16, 18-lactones thereof, e.g. reserpic acid lactone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/475—Quinolines; Isoquinolines having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP5359977A JPS53139731A (en) | 1977-05-10 | 1977-05-10 | Hypotensive agent containing methyl reserpate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| FR2390163A1 true FR2390163A1 (fr) | 1978-12-08 |
Family
ID=12947333
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR7813691A Withdrawn FR2390163A1 (fr) | 1977-05-10 | 1978-05-09 | Medicament et composition a base de reserpate de methyle pour le traitement de l'hypertension |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US4238491A (enExample) |
| JP (1) | JPS53139731A (enExample) |
| DE (1) | DE2820378A1 (enExample) |
| FR (1) | FR2390163A1 (enExample) |
| GB (1) | GB1570167A (enExample) |
-
1977
- 1977-05-10 JP JP5359977A patent/JPS53139731A/ja active Granted
-
1978
- 1978-05-09 US US05/904,290 patent/US4238491A/en not_active Expired - Lifetime
- 1978-05-09 FR FR7813691A patent/FR2390163A1/fr not_active Withdrawn
- 1978-05-09 GB GB18544/78A patent/GB1570167A/en not_active Expired
- 1978-05-10 DE DE19782820378 patent/DE2820378A1/de active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| GB1570167A (en) | 1980-06-25 |
| DE2820378C2 (enExample) | 1990-07-26 |
| DE2820378A1 (de) | 1978-11-23 |
| JPS6224406B2 (enExample) | 1987-05-28 |
| US4238491A (en) | 1980-12-09 |
| JPS53139731A (en) | 1978-12-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ST | Notification of lapse |