FR2387032A1 - Composition pharmaceutique pour l'administration orale de pancreatine - Google Patents
Composition pharmaceutique pour l'administration orale de pancreatineInfo
- Publication number
- FR2387032A1 FR2387032A1 FR7809663A FR7809663A FR2387032A1 FR 2387032 A1 FR2387032 A1 FR 2387032A1 FR 7809663 A FR7809663 A FR 7809663A FR 7809663 A FR7809663 A FR 7809663A FR 2387032 A1 FR2387032 A1 FR 2387032A1
- Authority
- FR
- France
- Prior art keywords
- pancreatin
- unit dose
- gastric juice
- administration
- inactivating
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 108010019160 Pancreatin Proteins 0.000 abstract 7
- 229940055695 pancreatin Drugs 0.000 abstract 7
- 210000004051 gastric juice Anatomy 0.000 abstract 3
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 230000000415 inactivating effect Effects 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 239000007789 gas Substances 0.000 abstract 1
- 210000001035 gastrointestinal tract Anatomy 0.000 abstract 1
- 230000002779 inactivation Effects 0.000 abstract 1
- 150000002500 ions Chemical class 0.000 abstract 1
- 230000003204 osmotic effect Effects 0.000 abstract 1
- 229920006254 polymer film Polymers 0.000 abstract 1
- 210000001187 pylorus Anatomy 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 230000008961 swelling Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0065—Forms with gastric retention, e.g. floating on gastric juice, adhering to gastric mucosa, expanding to prevent passage through the pylorus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4891—Coated capsules; Multilayered drug free capsule shells
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La présente invention est relative à une dose unitaire pour l'administration de pancréatine, qui peut être avalée, caractérisée en ce qu'elle comprend un agent de distension qui est compatible avec la pancréatine et qui exerce une pression osmotique lorsqu'il est placé dans une solution aqueuse, cet agent de distension, associé à la pancréatine et au moins un produit basique solide physiologiquement acceptable qui est compatible avec la pancréatine et qui donne un pH de 6 à 10, qui ne contient pas d'ions inactivant la pancréatine et qui ne produit pas de gaz acides ni ne se décompose par stockage en donnant des substances inactivant la pancréatine, étant enfermé hermétiquement dans une pellicule polymère semi-perméable qui résiste à l'attaque par le suc gastrique mais lui est perméable, cette dose unitaire gonflant sans se casser lorsqu'elle est au contact du suc gastrique jusqu'à une taille telle qu'elle se rompe mécaniquement dans la région du sphincter pylorique. Cette dose unitaire permet l'administration de pancréatine à l'endroit approprié du tractus digestif en empochant son inactivation par le suc gastrique.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB15506/77A GB1561613A (en) | 1977-04-14 | 1977-04-14 | Pharmaceutical oral dosage forms containing pancreatin |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2387032A1 true FR2387032A1 (fr) | 1978-11-10 |
| FR2387032B1 FR2387032B1 (fr) | 1981-06-12 |
Family
ID=10060342
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR7809663A Granted FR2387032A1 (fr) | 1977-04-14 | 1978-03-31 | Composition pharmaceutique pour l'administration orale de pancreatine |
Country Status (5)
| Country | Link |
|---|---|
| JP (1) | JPS53127818A (fr) |
| DE (1) | DE2816051A1 (fr) |
| FR (1) | FR2387032A1 (fr) |
| GB (1) | GB1561613A (fr) |
| IT (1) | IT1095388B (fr) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE454566B (sv) * | 1984-04-24 | 1988-05-16 | Lars G I Hellgren | Farmaceutisk komposition innehallande en verksam mengd av vattenlosliga proteinaser som extraherats fran ett vattenlevande djur valt av ordningen euphausiaceae eller slektet mallotus |
| US4976949A (en) * | 1985-10-25 | 1990-12-11 | The University Of Michigan | Controlled release dosage form |
| DE3642853A1 (de) * | 1986-12-16 | 1988-06-23 | Ulrich Von Dr Ing Pidoll | Arzneimittel |
| SE8703064D0 (sv) * | 1987-08-06 | 1987-08-06 | Viggo Mohr | Method for isolating active enzyme preparations from animal tissues |
| DE4332985A1 (de) * | 1993-09-28 | 1995-03-30 | Konrad Peter Maria Dr Sommer | Arzneimittel zur Behandlung der Dysfunktion des exokrinen Pankreas |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1469342A (fr) * | 1965-02-15 | 1967-02-10 | Biorex Laboratories Ltd | Dose unitaire perfectionnée pour l'administration de médicaments |
| FR7392M (fr) * | 1966-07-19 | 1969-11-03 |
-
1977
- 1977-04-14 GB GB15506/77A patent/GB1561613A/en not_active Expired
-
1978
- 1978-03-31 FR FR7809663A patent/FR2387032A1/fr active Granted
- 1978-04-07 JP JP4169878A patent/JPS53127818A/ja active Pending
- 1978-04-13 DE DE19782816051 patent/DE2816051A1/de not_active Withdrawn
- 1978-04-14 IT IT22316/78A patent/IT1095388B/it active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1469342A (fr) * | 1965-02-15 | 1967-02-10 | Biorex Laboratories Ltd | Dose unitaire perfectionnée pour l'administration de médicaments |
| FR7392M (fr) * | 1966-07-19 | 1969-11-03 |
Also Published As
| Publication number | Publication date |
|---|---|
| DE2816051A1 (de) | 1978-10-26 |
| GB1561613A (en) | 1980-02-27 |
| IT7822316A0 (it) | 1978-04-14 |
| FR2387032B1 (fr) | 1981-06-12 |
| IT1095388B (it) | 1985-08-10 |
| JPS53127818A (en) | 1978-11-08 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US9901611B2 (en) | Glutathione formulation and method of use | |
| KR890001598A (ko) | 유익한 약제를 투여하는 투약부재가 있는 투약기 | |
| DE69122751D1 (de) | Arzneimittelzusammensetzung mit kontrollierter wirkstoffabgabe | |
| KR920700620A (ko) | 서방성 경구 제형 | |
| JP3667381B2 (ja) | 解熱鎮痛剤 | |
| JP4691312B2 (ja) | 唾液、胃、大腸におけるアセトアルデヒドを結合するための方法および製剤 | |
| KR950007841A (ko) | 트라마돌 염을 함유하는 서방성 약물 제제 | |
| ATE227136T1 (de) | Mittel zur verstaerkten aufnahme polarer arzneistoffe aus dem kolon | |
| JPS62181227A (ja) | 固体持続放出医薬製剤 | |
| GB1093286A (en) | Improvements in or relating to dosage unit forms for the administration of medicaments and diagnostic agents | |
| FI87528C (fi) | Foerfarande foer framstaellning av en oral dosenhet av kaliumklorid | |
| ATE211649T1 (de) | Dosisform mit gesteuerter freigabe für kalium | |
| Levy et al. | Ammonia burns of the face and respiratory tract | |
| JPH0358935A (ja) | ヒアルロン酸塩の安定な平衡塩媒体溶液 | |
| RU2349345C2 (ru) | Фармацевтическая препаративная форма | |
| FR2387032A1 (fr) | Composition pharmaceutique pour l'administration orale de pancreatine | |
| Ong et al. | Potassium permanganate poisoning--a rare cause of fatal self poisoning. | |
| US20100310541A1 (en) | Compositions and Methods for Reducing the Toxicity of Certain Toxins | |
| Marcus et al. | Ulcerative disease of the colon in laboratory animals induced by pepsin inhibitors | |
| Bauer et al. | The action of intestinal enzymes upon cellulose acetate phthalate and butyl stearate enteric‐coated tablets | |
| CA2267543A1 (fr) | Utilisation de sulodexide et des medicaments qui en contiennent dans le traitement de la retinopathie diabetique | |
| Saw et al. | Hepatic Ascariasis: A Case Report and Review of the Literature | |
| JPS57140710A (en) | Capsule agent for rectal administration | |
| EP0178299A1 (fr) | Forme de dosage orale a liberation entretenue pour naproxyn | |
| JP2019156721A (ja) | 血流改善用可食組成物 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ST | Notification of lapse |