FR2380261A2 - Substd. meta-tri:fluoromethyl-phenyl piperidine cpds. - having antidepressant, antiparkinson and anorexigenic activity - Google Patents

Substd. meta-tri:fluoromethyl-phenyl piperidine cpds. - having antidepressant, antiparkinson and anorexigenic activity

Info

Publication number
FR2380261A2
FR2380261A2 FR7703917A FR7703917A FR2380261A2 FR 2380261 A2 FR2380261 A2 FR 2380261A2 FR 7703917 A FR7703917 A FR 7703917A FR 7703917 A FR7703917 A FR 7703917A FR 2380261 A2 FR2380261 A2 FR 2380261A2
Authority
FR
France
Prior art keywords
antiparkinson
substd
cpds
antidepressant
fluoromethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7703917A
Other languages
French (fr)
Other versions
FR2380261B2 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Roussel Uclaf SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf SA filed Critical Roussel Uclaf SA
Priority to FR7703917A priority Critical patent/FR2380261A2/en
Publication of FR2380261A2 publication Critical patent/FR2380261A2/en
Application granted granted Critical
Publication of FR2380261B2 publication Critical patent/FR2380261B2/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/42—Oxygen atoms attached in position 3 or 5

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

m-Trifluoromethyl phenyl piperidines of formula (I) and their salts are new: (where R is propyl or phenylmethyl). A typical prod. is N-propyl-3-(m-trifluoromethylphenyl)piperidine oxalate. In an example, this was prepd. by treating 3-(m-trifluoromethylphenyl) piperidine with silver oxide and propyl iodide, in acetone at ambient temp. The product was then treated with oxalic acid to form the salt.
FR7703917A 1977-02-11 1977-02-11 Substd. meta-tri:fluoromethyl-phenyl piperidine cpds. - having antidepressant, antiparkinson and anorexigenic activity Granted FR2380261A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR7703917A FR2380261A2 (en) 1977-02-11 1977-02-11 Substd. meta-tri:fluoromethyl-phenyl piperidine cpds. - having antidepressant, antiparkinson and anorexigenic activity

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7703917A FR2380261A2 (en) 1977-02-11 1977-02-11 Substd. meta-tri:fluoromethyl-phenyl piperidine cpds. - having antidepressant, antiparkinson and anorexigenic activity

Publications (2)

Publication Number Publication Date
FR2380261A2 true FR2380261A2 (en) 1978-09-08
FR2380261B2 FR2380261B2 (en) 1980-12-19

Family

ID=9186622

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7703917A Granted FR2380261A2 (en) 1977-02-11 1977-02-11 Substd. meta-tri:fluoromethyl-phenyl piperidine cpds. - having antidepressant, antiparkinson and anorexigenic activity

Country Status (1)

Country Link
FR (1) FR2380261A2 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0007067A1 (en) * 1978-07-05 1980-01-23 Ciba-Geigy Ag Phenylpiperidine derivatives, processes for their preparation and pharmaceutical compositions containing them
WO1981001552A1 (en) * 1979-12-05 1981-06-11 Astra Laekemedel Ab New phenyl-azacycloalkanes

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0007067A1 (en) * 1978-07-05 1980-01-23 Ciba-Geigy Ag Phenylpiperidine derivatives, processes for their preparation and pharmaceutical compositions containing them
WO1981001552A1 (en) * 1979-12-05 1981-06-11 Astra Laekemedel Ab New phenyl-azacycloalkanes

Also Published As

Publication number Publication date
FR2380261B2 (en) 1980-12-19

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