FR2379515A1 - NEW DERIVATIVES OF THE BENZENE-SULFAMIDE AND BENZENE-CARBOXAMIDE TYPE, THEIR USE AND THEIR PREPARATION - Google Patents

NEW DERIVATIVES OF THE BENZENE-SULFAMIDE AND BENZENE-CARBOXAMIDE TYPE, THEIR USE AND THEIR PREPARATION

Info

Publication number
FR2379515A1
FR2379515A1 FR7803114A FR7803114A FR2379515A1 FR 2379515 A1 FR2379515 A1 FR 2379515A1 FR 7803114 A FR7803114 A FR 7803114A FR 7803114 A FR7803114 A FR 7803114A FR 2379515 A1 FR2379515 A1 FR 2379515A1
Authority
FR
France
Prior art keywords
benzene
group
hydrogen
alkyl
general formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7803114A
Other languages
French (fr)
Other versions
FR2379515B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Allen and Hanburys Ltd
Original Assignee
Allen and Hanburys Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB4419/77A external-priority patent/GB1593651A/en
Application filed by Allen and Hanburys Ltd filed Critical Allen and Hanburys Ltd
Publication of FR2379515A1 publication Critical patent/FR2379515A1/en
Application granted granted Critical
Publication of FR2379515B1 publication Critical patent/FR2379515B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
    • C07D295/112—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings

Abstract

The novel benzenesulphonamide and benzamide derivatives of the general formula: in which R1 represents a halogen atom or the group NR2R3; R2 and R3, which can be identical or different, represent hydrogen or straight-chain or branched (C1-C6)-alkyl, or where R2 and R3, together with the nitrogen atom, can form a 5- or 6-membered heterocyclic ring which can contain a further heteroatom from the group O, N or S, or where R2 represents hydrogen and R3 represents the group R4CO or R4SO2, in which R4 has the meaning hydrogen or (C1-4)-alkyl; R5 represents hydrogen or one or more halogen atoms or hydroxy- or (C1-4)-alkoxy groups; X represents CH2, O or the group NR6, in which NR6 has the meaning hydrogen or (C1-4)-alkyl, and Y represents SO2NH2 or CONH2, and the acid addition salts with organic or inorganic acids thereof are suitable for the treatment of cardiovascular disorders, such as hypertension. These compounds are prepared by reductive alkylation of a compound of the general formula: with a ketone of the general formula:
FR7803114A 1977-02-03 1978-02-03 NEW DERIVATIVES OF THE BENZENE-SULFAMIDE AND BENZENE-CARBOXAMIDE TYPE, THEIR USE AND THEIR PREPARATION Granted FR2379515A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB442077 1977-02-03
GB4419/77A GB1593651A (en) 1977-02-03 1977-02-03 Amides

Publications (2)

Publication Number Publication Date
FR2379515A1 true FR2379515A1 (en) 1978-09-01
FR2379515B1 FR2379515B1 (en) 1981-07-31

Family

ID=26239110

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7803114A Granted FR2379515A1 (en) 1977-02-03 1978-02-03 NEW DERIVATIVES OF THE BENZENE-SULFAMIDE AND BENZENE-CARBOXAMIDE TYPE, THEIR USE AND THEIR PREPARATION

Country Status (10)

Country Link
JP (1) JPS6011898B2 (en)
AU (1) AU521707B2 (en)
CH (1) CH642057A5 (en)
DE (1) DE2803688A1 (en)
DK (1) DK31578A (en)
ES (2) ES466587A1 (en)
FR (1) FR2379515A1 (en)
NL (1) NL7801216A (en)
NZ (1) NZ186310A (en)
SE (1) SE7800930L (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2405931A1 (en) * 1977-10-12 1979-05-11 Yamanouchi Pharma Co Ltd NEW PHENYLETHANOLAMINE DERIVATIVES USEFUL AS ANTIHYPERTENSIFY AGENTS AND THEIR PREPARATION PROCESS
EP0028105A1 (en) * 1979-10-25 1981-05-06 Beecham Group Plc Secondary amines, their preparation and use in pharmaceutical compositions
DE19626030B4 (en) * 1995-07-05 2007-10-25 De Beers Industrial Diamond Division (Proprietary) Ltd., Theta Support of drill bits

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5553262A (en) * 1978-10-17 1980-04-18 Yamanouchi Pharmaceut Co Ltd Phenylethanolamine derivative
PH25150A (en) * 1986-06-05 1991-03-13 Ciba Geigy Ag Novel pharmaceutical preparation for topical application
US4906634A (en) * 1988-03-08 1990-03-06 Schering A.G. Novel N-[4-(aminosubstituted)phenyl]methanesulfonamides and their use as cardiovascular agents
AU2737295A (en) * 1994-06-09 1996-01-04 Glaxo Group Limited Phenethanolamine derivatives and their use as atypical beta-adrenoceptor agonists
PT882707E (en) 1996-01-10 2004-02-27 Asahi Chemical Ind NEW TRICYLIC COMPOUNDS AND MEDICINAL COMPOSITIONS CONTAINING THE SAME

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3860647A (en) * 1973-08-20 1975-01-14 Smithkline Corp {60 -Aminomethyl-4-hydroxy-3-sulfamyl-benzyl alcohols and 4-hydroxy-3-sulfamyl phenethylamines

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1266058A (en) * 1969-07-08 1972-03-08
SE7604448L (en) * 1975-04-17 1976-10-18 Scherico Ltd DIASTEREOISOMERS OF PHENYLAMINOETANOL DERIVATIVES

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3860647A (en) * 1973-08-20 1975-01-14 Smithkline Corp {60 -Aminomethyl-4-hydroxy-3-sulfamyl-benzyl alcohols and 4-hydroxy-3-sulfamyl phenethylamines

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2405931A1 (en) * 1977-10-12 1979-05-11 Yamanouchi Pharma Co Ltd NEW PHENYLETHANOLAMINE DERIVATIVES USEFUL AS ANTIHYPERTENSIFY AGENTS AND THEIR PREPARATION PROCESS
EP0028105A1 (en) * 1979-10-25 1981-05-06 Beecham Group Plc Secondary amines, their preparation and use in pharmaceutical compositions
DE19626030B4 (en) * 1995-07-05 2007-10-25 De Beers Industrial Diamond Division (Proprietary) Ltd., Theta Support of drill bits

Also Published As

Publication number Publication date
AU3273178A (en) 1979-08-02
FR2379515B1 (en) 1981-07-31
NZ186310A (en) 1979-10-25
JPS53111029A (en) 1978-09-28
CH642057A5 (en) 1984-03-30
JPS6011898B2 (en) 1985-03-28
ES466587A1 (en) 1979-01-16
DE2803688A1 (en) 1978-08-10
DK31578A (en) 1978-08-04
SE7800930L (en) 1978-08-04
ES475157A1 (en) 1979-05-01
AU521707B2 (en) 1982-04-29
NL7801216A (en) 1978-08-07

Similar Documents

Publication Publication Date Title
NO931151L (en) PROCEDURE FOR THE PREPARATION OF NITROGEN CONTAINING HETEROCYCLIC COMPOUNDS WITH CONDENSED RINGS
FI102965B1 (en) Condensed heterocyclic compounds, their preparation and use
IE45833L (en) N-quinolizinyl (or indolizinyl) benzamides.
NO881264L (en) PROCEDURE FOR THE PREPARATION OF HETEROCYCLIC COMPOUNDS.
FR2379515A1 (en) NEW DERIVATIVES OF THE BENZENE-SULFAMIDE AND BENZENE-CARBOXAMIDE TYPE, THEIR USE AND THEIR PREPARATION
ATE35137T1 (en) THIENO(2,3-D)PYRIMIDINE DERIVATIVES AND THEIR SALTS.
NO305287B1 (en) AMPA antagonists
BG60338B2 (en) Thienothiazines
AR246962A1 (en) Procedure for preparing alkylamine-alkylenic derivatives of certain 2h-1-benzo pyrenes.
SE7704616L (en) WAY TO PRODUCE NEW 11-DESOXY-PROSTAGLANDIN-FŸ2-DERIVATIVES
ATE74496T1 (en) SWEETENERS DERIVED FROM GUANIDININE AND ETHANAMIDINEACETIC ACIDS, THEIR USE AND COMPOSITIONS CONTAINING SUCH SWEETENERS.
ES2046528T3 (en) HETEROTETRACICLIC DERIVATIVES OF LACTAMS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS BASED ON THE SAME.
SE7812371L (en) PROCEDURE FOR PREPARING PHENOXIAL CANOLAMINE DERIVATIVES
BG60248B2 (en) Process for the preparation of phenoxyethylamine derivatives
ES2063157T3 (en) NEW DERIVATIVES OF INDOL, ITS PREPARATION PROCEDURE AND THE PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM.
ES451293A1 (en) A procedure for the preparation of tienotiacin derivatives. (Machine-translation by Google Translate, not legally binding)
ES465136A1 (en) Acyl derivatives of hellebrigenin
SU617582A1 (en) Composition for removing asphaltene-tar deposits
ES453829A1 (en) Procedure for preparation of quinazolinones (Machine-translation by Google Translate, not legally binding)
SE7513795L (en) PROCEDURE FOR MAKING NEW CYCLOPROPYLMETHYLAMINE DERVAT
SE8303131D0 (en) ISOQUINOLINE DERIVATIVES
ES432473A1 (en) Procedure for the preparation of new derivatives of bifenilo. (Machine-translation by Google Translate, not legally binding)
ES457552A1 (en) Amino-alkoxycycloalkanes
ES2063963T3 (en) NEW ARYLOXY-ALKYLAMINS, THEIR PREPARATION AND THE MEDICINES THAT CONTAIN THEM.
TH4776EX (en) New quinoline derivatives and processes for their preparation

Legal Events

Date Code Title Description
ST Notification of lapse