ES465136A1 - Acyl derivatives of hellebrigenin - Google Patents
Acyl derivatives of hellebrigeninInfo
- Publication number
- ES465136A1 ES465136A1 ES465136A ES465136A ES465136A1 ES 465136 A1 ES465136 A1 ES 465136A1 ES 465136 A ES465136 A ES 465136A ES 465136 A ES465136 A ES 465136A ES 465136 A1 ES465136 A1 ES 465136A1
- Authority
- ES
- Spain
- Prior art keywords
- radicals
- group
- alcohol
- nr1r2
- alkenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J19/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 by a lactone ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
Abstract
Procedure for the preparation of new helebrigenin derivatives of the general formula ** (Formula) in which R is a C1-C6-alcohol group, containing the -NR1R2 group, where R1 and R2 are C1-C6-alcohol radicals, radicals C2-C6-alkenyl, C1-C6-alcoholic radicals or C3-C6-alkenyl radicals substituted with C1-C6-alkoxy groups or with halogen atoms, and one of the radicals R1 or R2 can also mean a hydrogen atom, or the group -NR1R2 forming a saturated 5- or 6-membered heterocyclic ring, which may also contain another oxygen or nitrogen atom and one of such rings may also be substituted once or twice with C1-C6-alcohol groups, with group hydroxyethyl or with hydroxy groups, and R3 means the group - CHO, CH2OH or -CO2H, of their optically active forms and of their salts. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB52759/76A GB1577633A (en) | 1976-12-17 | 1976-12-17 | Acyl derivatives of hellebrigenin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES465136A1 true ES465136A1 (en) | 1979-01-01 |
Family
ID=10465185
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES465136A Expired ES465136A1 (en) | 1976-12-17 | 1977-12-16 | Acyl derivatives of hellebrigenin |
| ES465135A Expired ES465135A1 (en) | 1976-12-17 | 1977-12-16 | Acyl derivatives of hellebrigenin |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES465135A Expired ES465135A1 (en) | 1976-12-17 | 1977-12-16 | Acyl derivatives of hellebrigenin |
Country Status (15)
| Country | Link |
|---|---|
| JP (1) | JPS591279B2 (en) |
| AT (1) | AT372391B (en) |
| BE (1) | BE861968A (en) |
| CH (1) | CH639107A5 (en) |
| DD (1) | DD133151A5 (en) |
| DE (1) | DE2755122C2 (en) |
| ES (2) | ES465136A1 (en) |
| FI (1) | FI58135C (en) |
| FR (1) | FR2374336A1 (en) |
| GB (1) | GB1577633A (en) |
| HU (1) | HU176767B (en) |
| IT (1) | IT1113251B (en) |
| PL (1) | PL110178B1 (en) |
| SU (2) | SU751328A3 (en) |
| ZA (1) | ZA777494B (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS61158784U (en) * | 1985-03-25 | 1986-10-01 | ||
| EP1108702A1 (en) * | 1999-12-13 | 2001-06-20 | Kvaerner Process Technology Limited | Process for the co-production of aliphatic diols and cyclic ethers |
| WO2010102673A1 (en) * | 2009-03-13 | 2010-09-16 | Unibioscreen S.A. | Hellebrin and hellebrigenin derivatives |
| MY162934A (en) * | 2010-04-27 | 2017-07-31 | Pharma Mar Sa | Anticancer steroidal lactones unsaturated in position 7 (8) |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1901484A1 (en) * | 1969-01-14 | 1970-10-29 | Hoechst Ag | Cardiac active oxyesters of steroid cardenolides and steroid bufandienolides and processes for their preparation |
-
1976
- 1976-12-17 GB GB52759/76A patent/GB1577633A/en not_active Expired
-
1977
- 1977-12-10 DE DE2755122A patent/DE2755122C2/en not_active Expired
- 1977-12-13 IT IT52184/77A patent/IT1113251B/en active
- 1977-12-15 FR FR7737795A patent/FR2374336A1/en active Granted
- 1977-12-15 SU SU772553849A patent/SU751328A3/en active
- 1977-12-15 ZA ZA00777494A patent/ZA777494B/en unknown
- 1977-12-16 ES ES465136A patent/ES465136A1/en not_active Expired
- 1977-12-16 FI FI773814A patent/FI58135C/en not_active IP Right Cessation
- 1977-12-16 BE BE6046270A patent/BE861968A/en not_active IP Right Cessation
- 1977-12-16 DD DD7700202719A patent/DD133151A5/en unknown
- 1977-12-16 JP JP52152295A patent/JPS591279B2/en not_active Expired
- 1977-12-16 ES ES465135A patent/ES465135A1/en not_active Expired
- 1977-12-16 HU HU77DE947A patent/HU176767B/en unknown
- 1977-12-16 PL PL1977203030A patent/PL110178B1/en not_active IP Right Cessation
- 1977-12-16 AT AT0903877A patent/AT372391B/en not_active IP Right Cessation
-
1978
- 1978-01-01 CH CH1554377A patent/CH639107A5/en not_active IP Right Cessation
- 1978-12-25 SU SU782701599A patent/SU795487A3/en active
Also Published As
| Publication number | Publication date |
|---|---|
| JPS5395956A (en) | 1978-08-22 |
| AT372391B (en) | 1983-09-26 |
| BE861968A (en) | 1978-06-16 |
| SU795487A3 (en) | 1981-01-07 |
| DD133151A5 (en) | 1978-12-13 |
| FR2374336A1 (en) | 1978-07-13 |
| IT1113251B (en) | 1986-01-20 |
| CH639107A5 (en) | 1983-10-31 |
| HU176767B (en) | 1981-05-28 |
| ES465135A1 (en) | 1978-10-01 |
| ATA903877A (en) | 1983-02-15 |
| JPS591279B2 (en) | 1984-01-11 |
| FR2374336B1 (en) | 1980-11-07 |
| SU751328A3 (en) | 1980-07-23 |
| DE2755122A1 (en) | 1978-06-22 |
| ZA777494B (en) | 1979-02-28 |
| FI58135B (en) | 1980-08-29 |
| PL110178B1 (en) | 1980-07-31 |
| PL203030A1 (en) | 1979-03-26 |
| GB1577633A (en) | 1980-10-29 |
| DE2755122C2 (en) | 1983-06-30 |
| FI773814A (en) | 1978-06-18 |
| FI58135C (en) | 1980-12-10 |
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