FR2372627A1 - Antiallergic (4)-hydroxy-(3)-nitro-coumarin derivs. - e.g. (4)-hydroxy-(3)-nitro (7)-phenylethoxy-coumarin - Google Patents

Antiallergic (4)-hydroxy-(3)-nitro-coumarin derivs. - e.g. (4)-hydroxy-(3)-nitro (7)-phenylethoxy-coumarin

Info

Publication number
FR2372627A1
FR2372627A1 FR7628467A FR7628467A FR2372627A1 FR 2372627 A1 FR2372627 A1 FR 2372627A1 FR 7628467 A FR7628467 A FR 7628467A FR 7628467 A FR7628467 A FR 7628467A FR 2372627 A1 FR2372627 A1 FR 2372627A1
Authority
FR
France
Prior art keywords
coumarin
nitro
hydroxy
alkylene
derivs
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7628467A
Other languages
French (fr)
Other versions
FR2372627B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beecham Group PLC
Original Assignee
Beecham Group PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Group PLC filed Critical Beecham Group PLC
Publication of FR2372627A1 publication Critical patent/FR2372627A1/en
Application granted granted Critical
Publication of FR2372627B1 publication Critical patent/FR2372627B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/42—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms in positions 2 and 4
    • C07D311/56—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms in positions 2 and 4 without hydrogen atoms in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/03—Ethers having all ether-oxygen atoms bound to acyclic carbon atoms
    • C07C43/14—Unsaturated ethers
    • C07C43/178—Unsaturated ethers containing hydroxy or O-metal groups
    • C07C43/1786—Unsaturated ethers containing hydroxy or O-metal groups containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
    • C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
    • C07D311/08—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring
    • C07D311/18—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring substituted otherwise than in position 3 or 7
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/42—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms in positions 2 and 4
    • C07D311/44—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms in positions 2 and 4 with one hydrogen atom in position 3
    • C07D311/54—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms in positions 2 and 4 with one hydrogen atom in position 3 substituted in the carbocyclic ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)

Abstract

New nitrocoumarins are of formula (I) (where R1 and R2 are each H, lower alkoxy, alk(en)yl or alkynyl, or together form 3-5C alkylene or -CH=CH-CH=CH-; A is of formula (II) in 6- or 7- posn. of the nitrocoumarin ring; X is O or CH2; Q is 1-8C linear alkylene opt. OH substd. other than on a CH2 gp. bonded to the ether O; R3 5 are each H, halogen, NO2, OH, CN, carboxyl, amino, lower alk(en)yl, alkynl, alkoxy(carbonyl) or acyl(oxy), mono- or di-lower alkyl amino, mono-or di-lower acylamino, pheyl, lower alkylphenyl, phenoxycarbonyl, benzyloxycarbonyl, or 2 of R3 5 together form 3-5C alkylene or -CH=CH-CH=CH-). (I) are useful in the prophylaxis and treatment of e.g. bronchial asthma, rhinitis, hay fever, allergi c eczema, etc.
FR7628467A 1975-09-23 1976-09-22 Antiallergic (4)-hydroxy-(3)-nitro-coumarin derivs. - e.g. (4)-hydroxy-(3)-nitro (7)-phenylethoxy-coumarin Granted FR2372627A1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB3904175 1975-09-23
GB3904275 1975-09-23
GB432176 1976-02-04
GB2445076 1976-06-12

Publications (2)

Publication Number Publication Date
FR2372627A1 true FR2372627A1 (en) 1978-06-30
FR2372627B1 FR2372627B1 (en) 1979-03-23

Family

ID=27447372

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7628467A Granted FR2372627A1 (en) 1975-09-23 1976-09-22 Antiallergic (4)-hydroxy-(3)-nitro-coumarin derivs. - e.g. (4)-hydroxy-(3)-nitro (7)-phenylethoxy-coumarin

Country Status (15)

Country Link
AU (1) AU1808976A (en)
BE (1) BE846385A (en)
DE (1) DE2642248A1 (en)
DK (1) DK427476A (en)
ES (2) ES451804A1 (en)
FI (1) FI762579A (en)
FR (1) FR2372627A1 (en)
GR (1) GR61306B (en)
IL (1) IL50465A0 (en)
LU (1) LU75845A1 (en)
NL (1) NL7610509A (en)
NO (1) NO763233L (en)
NZ (1) NZ181995A (en)
PT (1) PT65588B (en)
SE (1) SE7610367L (en)

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
NEANT *

Also Published As

Publication number Publication date
IL50465A0 (en) 1976-11-30
NO763233L (en) 1977-03-24
FR2372627B1 (en) 1979-03-23
DK427476A (en) 1977-03-24
ES463258A1 (en) 1978-12-01
SE7610367L (en) 1977-03-24
PT65588B (en) 1978-03-28
AU1808976A (en) 1978-04-06
ES451804A1 (en) 1978-02-16
PT65588A (en) 1976-10-01
FI762579A (en) 1977-03-24
NZ181995A (en) 1978-09-25
DE2642248A1 (en) 1977-03-31
GR61306B (en) 1978-10-19
LU75845A1 (en) 1977-05-04
NL7610509A (en) 1977-03-25
BE846385A (en) 1977-03-21

Similar Documents

Publication Publication Date Title
IT1065486B (en) ETHER OF AN OXY PROCEDURE FOR ITS PREPARATION AND ITS USE AS AN ANTIDOTE FOR HERBICIDES DAMAGE THE PLANTS
JPS5262213A (en) Polypluenyl derivatives
TR21604A (en) USE OF ALMOND ACID (PHENYLGLYCOLIC ACID) AND THE NITRILES OF THIS AND ITS PREPARATION AND THEIR USE FOR THE USE OF MICROORGANISMS
IT1170900B (en) ANTI-ALLERGIC AGENT
ATE239709T1 (en) RACEMIC HUPERZINE A
FR2002353A1 (en) 1 2-benzisothiazolone salts
SE416144B (en) CORRECTABLE MACHINE FOR COMPRESSION AND CORRECTION OF RAILWAY SAVINGS
FR2372627A1 (en) Antiallergic (4)-hydroxy-(3)-nitro-coumarin derivs. - e.g. (4)-hydroxy-(3)-nitro (7)-phenylethoxy-coumarin
ES434242A1 (en) Tetracyclic piperidino derivatives
FR2359153A1 (en) NEW CARBOXYL ESTERS OF PHOSPHONOACETIC ACID USEFUL IN PARTICULAR FOR THE TREATMENT OF SIMPLEX HERPICAL INFECTIONS
AR004950A1 (en) CYCLIC NITRONES, PHARMACEUTICAL COMPOSITION AND ITS USE FOR THE MANUFACTURE OF MEDICINES
SE409867B (en) PROCEDURE FOR THE PREPARATION OF DIKVATERANA AND MONOCVATERNERA SALTS OF NEW DIAMINO ANDROSTANES
ES2084348T3 (en) N - ((4,5-DIHIDROXI- Y 4,5,8-TRIHIDROXI-9,10-DIHIDRO-9,10-DIOXO-2-ANTRACEN-IL) CARBONIL) AMINO ACIDS USEFUL IN THE THERAPY OF OSTEOARTICULAR DISEASES.
IT1059533B (en) Tricyclic chromone-2-carboxylic acid derivs - with anti-allergic activity (BE280576)
SE7907532L (en) AURON DERIVATIVES
PH13389A (en) Substituted n-(phenyl)-dithiocarbamic acid ester,pharmaceutical compositions and method of using same
IT1096279B (en) PHARMACEUTICAL COMPOUND OF IMPROVED MUCOLITIC AND FLUIDIFYING ACTIVITY OF MUCOUS SECRETIONS
EP0000644A3 (en) Lower cycloalkyl substituted-benzene derivatives, the preparation thereof and their pharmaceutical compositions
BE881625A (en) O-ALCOXYCARBONYL-PHENYL ESTERS OF AN ANTHRANILIC ACID, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME
ES481296A1 (en) Ester derivatives of quinolopyran-4-one-2-carboxylic acids and antiallergic antasthmatics
SE8300495L (en) IMPROVEMENTS OR IN CONNECTION WITH NASAL PHARMACEUTICAL COMPOSITIONS
ES555619A0 (en) A PROCEDURE FOR PREPARING THIOIMIDAZOLE DERIVATIVES
SU76627A1 (en) The method of preparation of an antiseptic solution of eucalyptus leaves for the treatment of purulent diseases and other purposes
FR2092785A1 (en) 2-azaquinolizidine derivs and salts neurotropic and anti - -histamine agents synthesis
JPS52263A (en) Process for preparation of 1-alkanesulfonyloxy alkyl-2-alkyl-3-dipheny lmethylenepyrrolidine and its salts

Legal Events

Date Code Title Description
ST Notification of lapse