ES451804A1 - Antiallergic (4)-hydroxy-(3)-nitro-coumarin derivs. - e.g. (4)-hydroxy-(3)-nitro (7)-phenylethoxy-coumarin - Google Patents
Antiallergic (4)-hydroxy-(3)-nitro-coumarin derivs. - e.g. (4)-hydroxy-(3)-nitro (7)-phenylethoxy-coumarinInfo
- Publication number
- ES451804A1 ES451804A1 ES451804A ES451804A ES451804A1 ES 451804 A1 ES451804 A1 ES 451804A1 ES 451804 A ES451804 A ES 451804A ES 451804 A ES451804 A ES 451804A ES 451804 A1 ES451804 A1 ES 451804A1
- Authority
- ES
- Spain
- Prior art keywords
- coumarin
- nitro
- hydroxy
- alkylene
- derivs
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/42—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms in positions 2 and 4
- C07D311/56—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms in positions 2 and 4 without hydrogen atoms in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/02—Ethers
- C07C43/03—Ethers having all ether-oxygen atoms bound to acyclic carbon atoms
- C07C43/14—Unsaturated ethers
- C07C43/178—Unsaturated ethers containing hydroxy or O-metal groups
- C07C43/1786—Unsaturated ethers containing hydroxy or O-metal groups containing halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
- C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
- C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/10—Oxygen atoms
- C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
- C07D311/08—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring
- C07D311/18—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring substituted otherwise than in position 3 or 7
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/42—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms in positions 2 and 4
- C07D311/44—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms in positions 2 and 4 with one hydrogen atom in position 3
- C07D311/54—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms in positions 2 and 4 with one hydrogen atom in position 3 substituted in the carbocyclic ring
Abstract
New nitrocoumarins are of formula (I) (where R1 and R2 are each H, lower alkoxy, alk(en)yl or alkynyl, or together form 3-5C alkylene or -CH=CH-CH=CH- A is of formula (II) in 6- or 7- posn. of the nitrocoumarin ring X is O or CH2 Q is 1-8C linear alkylene opt. OH substd. other than on a CH2 gp. bonded to the ether O R3 5 are each H, halogen, NO2, OH, CN, carboxyl, amino, lower alk(en)yl, alkynl, alkoxy(carbonyl) or acyl(oxy), mono- or di-lower alkyl amino, mono-or di-lower acylamino, pheyl, lower alkylphenyl, phenoxycarbonyl, benzyloxycarbonyl, or 2 of R3 5 together form 3-5C alkylene or -CH=CH-CH=CH-). (I) are useful in the prophylaxis and treatment of e.g. bronchial asthma, rhinitis, hay fever, allergi c eczema, etc.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB3904175 | 1975-09-23 | ||
GB3904275 | 1975-09-23 | ||
GB432176 | 1976-02-04 | ||
GB2445076 | 1976-06-12 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES451804A1 true ES451804A1 (en) | 1978-02-16 |
Family
ID=27447372
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES451804A Expired ES451804A1 (en) | 1975-09-23 | 1976-09-23 | Antiallergic (4)-hydroxy-(3)-nitro-coumarin derivs. - e.g. (4)-hydroxy-(3)-nitro (7)-phenylethoxy-coumarin |
ES463258A Expired ES463258A1 (en) | 1975-09-23 | 1977-10-14 | Antiallergic (4)-hydroxy-(3)-nitro-coumarin derivs. - e.g. (4)-hydroxy-(3)-nitro (7)-phenylethoxy-coumarin |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES463258A Expired ES463258A1 (en) | 1975-09-23 | 1977-10-14 | Antiallergic (4)-hydroxy-(3)-nitro-coumarin derivs. - e.g. (4)-hydroxy-(3)-nitro (7)-phenylethoxy-coumarin |
Country Status (15)
Country | Link |
---|---|
AU (1) | AU1808976A (en) |
BE (1) | BE846385A (en) |
DE (1) | DE2642248A1 (en) |
DK (1) | DK427476A (en) |
ES (2) | ES451804A1 (en) |
FI (1) | FI762579A (en) |
FR (1) | FR2372627A1 (en) |
GR (1) | GR61306B (en) |
IL (1) | IL50465A0 (en) |
LU (1) | LU75845A1 (en) |
NL (1) | NL7610509A (en) |
NO (1) | NO763233L (en) |
NZ (1) | NZ181995A (en) |
PT (1) | PT65588B (en) |
SE (1) | SE7610367L (en) |
-
1976
- 1976-09-08 FI FI762579A patent/FI762579A/fi not_active Application Discontinuation
- 1976-09-09 NZ NZ181995A patent/NZ181995A/en unknown
- 1976-09-10 IL IL50465A patent/IL50465A0/en unknown
- 1976-09-13 PT PT65588A patent/PT65588B/en unknown
- 1976-09-16 GR GR51704A patent/GR61306B/en unknown
- 1976-09-17 SE SE7610367A patent/SE7610367L/en unknown
- 1976-09-20 DE DE19762642248 patent/DE2642248A1/en active Pending
- 1976-09-20 BE BE170778A patent/BE846385A/en unknown
- 1976-09-21 NO NO763233A patent/NO763233L/en unknown
- 1976-09-22 FR FR7628467A patent/FR2372627A1/en active Granted
- 1976-09-22 LU LU75845A patent/LU75845A1/xx unknown
- 1976-09-22 NL NL7610509A patent/NL7610509A/en not_active Application Discontinuation
- 1976-09-22 DK DK427476A patent/DK427476A/en unknown
- 1976-09-23 ES ES451804A patent/ES451804A1/en not_active Expired
- 1976-09-23 AU AU18089/76A patent/AU1808976A/en not_active Expired
-
1977
- 1977-10-14 ES ES463258A patent/ES463258A1/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
FR2372627A1 (en) | 1978-06-30 |
SE7610367L (en) | 1977-03-24 |
LU75845A1 (en) | 1977-05-04 |
IL50465A0 (en) | 1976-11-30 |
FR2372627B1 (en) | 1979-03-23 |
DE2642248A1 (en) | 1977-03-31 |
NZ181995A (en) | 1978-09-25 |
PT65588B (en) | 1978-03-28 |
PT65588A (en) | 1976-10-01 |
GR61306B (en) | 1978-10-19 |
FI762579A (en) | 1977-03-24 |
BE846385A (en) | 1977-03-21 |
NO763233L (en) | 1977-03-24 |
DK427476A (en) | 1977-03-24 |
ES463258A1 (en) | 1978-12-01 |
NL7610509A (en) | 1977-03-25 |
AU1808976A (en) | 1978-04-06 |
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