FR2371423A1 - Procede de preparation d'une s-carboxymethyl-l-cysteine de haute purete - Google Patents
Procede de preparation d'une s-carboxymethyl-l-cysteine de haute pureteInfo
- Publication number
- FR2371423A1 FR2371423A1 FR7728567A FR7728567A FR2371423A1 FR 2371423 A1 FR2371423 A1 FR 2371423A1 FR 7728567 A FR7728567 A FR 7728567A FR 7728567 A FR7728567 A FR 7728567A FR 2371423 A1 FR2371423 A1 FR 2371423A1
- Authority
- FR
- France
- Prior art keywords
- cysteine
- carboxymethyl
- high purity
- disodium salt
- chloroacetic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- GBFLZEXEOZUWRN-VKHMYHEASA-N S-carboxymethyl-L-cysteine Chemical compound OC(=O)[C@@H](N)CSCC(O)=O GBFLZEXEOZUWRN-VKHMYHEASA-N 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 abstract 4
- XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 abstract 4
- QXNVGIXVLWOKEQ-UHFFFAOYSA-N Disodium Chemical class [Na][Na] QXNVGIXVLWOKEQ-UHFFFAOYSA-N 0.000 abstract 3
- GBFLZEXEOZUWRN-VKHMYHEASA-M S-carboxylatomethyl-L-cysteine(1-) Chemical compound [O-]C(=O)[C@@H]([NH3+])CSCC([O-])=O GBFLZEXEOZUWRN-VKHMYHEASA-M 0.000 abstract 3
- FOCAUTSVDIKZOP-UHFFFAOYSA-N chloroacetic acid Chemical compound OC(=O)CCl FOCAUTSVDIKZOP-UHFFFAOYSA-N 0.000 abstract 3
- 229940106681 chloroacetic acid Drugs 0.000 abstract 3
- 235000013878 L-cysteine Nutrition 0.000 abstract 2
- 239000004201 L-cysteine Substances 0.000 abstract 2
- 229910021529 ammonia Inorganic materials 0.000 abstract 2
- 239000007864 aqueous solution Substances 0.000 abstract 2
- 238000006243 chemical reaction Methods 0.000 abstract 2
- PWKSKIMOESPYIA-UHFFFAOYSA-N 2-acetamido-3-sulfanylpropanoic acid Chemical compound CC(=O)NC(CS)C(O)=O PWKSKIMOESPYIA-UHFFFAOYSA-N 0.000 abstract 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 abstract 1
- LEVWYRKDKASIDU-IMJSIDKUSA-N L-cystine Chemical compound [O-]C(=O)[C@@H]([NH3+])CSSC[C@H]([NH3+])C([O-])=O LEVWYRKDKASIDU-IMJSIDKUSA-N 0.000 abstract 1
- 235000019393 L-cystine Nutrition 0.000 abstract 1
- 239000004158 L-cystine Substances 0.000 abstract 1
- 239000003638 chemical reducing agent Substances 0.000 abstract 1
- 229960003067 cystine Drugs 0.000 abstract 1
- 230000008020 evaporation Effects 0.000 abstract 1
- 238000001704 evaporation Methods 0.000 abstract 1
- 239000003172 expectorant agent Substances 0.000 abstract 1
- 229940066491 mucolytics Drugs 0.000 abstract 1
- 230000020477 pH reduction Effects 0.000 abstract 1
- 238000001556 precipitation Methods 0.000 abstract 1
- 229910052708 sodium Inorganic materials 0.000 abstract 1
- 239000011734 sodium Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2647094A DE2647094B1 (de) | 1976-10-19 | 1976-10-19 | Verfahren zur Herstellung von hochreinem S-Carboxymethyl-L-cystein |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2371423A1 true FR2371423A1 (fr) | 1978-06-16 |
| FR2371423B1 FR2371423B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1980-08-29 |
Family
ID=5990806
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR7728567A Granted FR2371423A1 (fr) | 1976-10-19 | 1977-09-22 | Procede de preparation d'une s-carboxymethyl-l-cysteine de haute purete |
Country Status (8)
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105418471B (zh) * | 2015-12-24 | 2017-09-05 | 宜昌三峡制药有限公司 | 一种羧甲司坦的合成方法 |
| CN106083673B (zh) * | 2016-06-29 | 2017-11-03 | 罗江晨明生物制品有限公司 | 一种羧甲司坦的制备工艺 |
| CN110563596B (zh) * | 2019-09-16 | 2022-07-26 | 山东泰和水处理科技股份有限公司 | 一种二羧甲基氨基酸盐的制备方法 |
| CN111138326A (zh) * | 2019-12-31 | 2020-05-12 | 宁波市远发生物工程有限公司 | 一种s-羧甲基-l-半胱氨酸的制备方法 |
| CN115557864B (zh) * | 2021-07-01 | 2024-06-18 | 广东众生药业股份有限公司 | 一种羧甲司坦的工业化制备方法 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2460785A (en) * | 1946-03-14 | 1949-02-01 | Merck & Co Inc | Processes for preparing substituted propanoic acid |
| US3184505A (en) * | 1962-06-18 | 1965-05-18 | Mead Johnson & Co | Process for the n-monoacylation of cysteine |
-
1976
- 1976-10-19 DE DE2647094A patent/DE2647094B1/de active Granted
-
1977
- 1977-08-15 NL NL7708981A patent/NL7708981A/xx not_active Application Discontinuation
- 1977-09-14 US US05/833,043 patent/US4129593A/en not_active Expired - Lifetime
- 1977-09-22 FR FR7728567A patent/FR2371423A1/fr active Granted
- 1977-10-14 GB GB42819/77A patent/GB1532940A/en not_active Expired
- 1977-10-18 BE BE6046183A patent/BE859870A/xx not_active IP Right Cessation
- 1977-10-18 JP JP12503777A patent/JPS5350118A/ja active Granted
- 1977-10-18 CH CH1269777A patent/CH628618A5/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| FR2371423B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1980-08-29 |
| GB1532940A (en) | 1978-11-22 |
| JPS5350118A (en) | 1978-05-08 |
| NL7708981A (nl) | 1978-04-21 |
| DE2647094C2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1979-02-08 |
| BE859870A (fr) | 1978-04-18 |
| DE2647094B1 (de) | 1978-04-13 |
| US4129593A (en) | 1978-12-12 |
| JPS5542987B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1980-11-04 |
| CH628618A5 (de) | 1982-03-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| GB1265485A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | ||
| FR2371423A1 (fr) | Procede de preparation d'une s-carboxymethyl-l-cysteine de haute purete | |
| GB1383939A (en) | Battery electrolyte composition | |
| GB1419759A (en) | Process for the manufacture of perfluoroalkyl-methylene carbo xylic acids | |
| GB1527473A (en) | Production of 3,3-dimethyl-2-hydroxy-butyric acid and its salts | |
| GB1444868A (en) | Process for the manufacture of sulphonic acid fluorides | |
| GB1506070A (en) | Method of producing sulphur-containing l-amino acid | |
| ATE144769T1 (de) | Prostaglandin e1-analoge | |
| ATE62250T1 (de) | Cytidine-diphosphocholine salze, besonders geeignet fuer oralen gebrauch. | |
| GB1244074A (en) | Process for the production of sodium methallyl sulphonate | |
| GB1366352A (en) | Resolution of dl-cysteine | |
| GB1341104A (en) | Method for preparation of aminodalkane-sulphonic acids | |
| GB1396368A (en) | Perfluoroalkyl sulphinic acids and a process for their production | |
| KR850001732A (ko) | 소염작용 및 점액 용해작용을 갖는 ⅳ-아세틸시스테인 및 s-카르복시메틸시스테인의 2',4'-디플루오로-4-히드록시-(1,1'-디페닐)-3-카르복실산 유도체의 제조방법 | |
| BG33282A3 (en) | Method for obtaining of 4- amino- 5- chlorine- 1- phenylpyridazon- (6) | |
| GB1462015A (en) | Water-soluble imidazole derivatives and a process for the preparation thereof | |
| GB1172632A (en) | Improvements in or relating to Processes for the Preparation of Naphthalene Disulfonic Acid. | |
| GB1304487A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | ||
| JPS554349A (en) | Preparation of creatine | |
| GB1333601A (en) | Process for the production of methallyl sulphonate salt solutions | |
| JPS53147026A (en) | Continuous preparation of thioglycolic acid | |
| ES451465A1 (es) | Procedimiento para la preparacion de s-carboximetil-1-cis- teina. | |
| ES467126A1 (es) | Procedimiento para preparar di-n-propilacetamida. | |
| IE780502L (en) | 2-aryl-2-[omega-(diisopropylamino) alkyl]-omega-¹(azabicycloalkyl)-alkanamides¹¹-w-(aza-bicycloalkyl)-alkanamides | |
| SU713866A1 (ru) | Способ получени изопропилксантогената щелочного металла |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ST | Notification of lapse |