FR2369248A1 - THYMOSIN USEFUL AS A MEDICINAL PRODUCT AND ITS PREPARATION PROCESS - Google Patents

THYMOSIN USEFUL AS A MEDICINAL PRODUCT AND ITS PREPARATION PROCESS

Info

Publication number
FR2369248A1
FR2369248A1 FR7732259A FR7732259A FR2369248A1 FR 2369248 A1 FR2369248 A1 FR 2369248A1 FR 7732259 A FR7732259 A FR 7732259A FR 7732259 A FR7732259 A FR 7732259A FR 2369248 A1 FR2369248 A1 FR 2369248A1
Authority
FR
France
Prior art keywords
glu
thymosin
useful
lys
preparation process
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7732259A
Other languages
French (fr)
Other versions
FR2369248B1 (en
Inventor
Allan L Goldstein
Teresa L K Low
Chun Yen Lai
Su Sun Wang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/766,638 external-priority patent/US4079127A/en
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of FR2369248A1 publication Critical patent/FR2369248A1/en
Application granted granted Critical
Publication of FR2369248B1 publication Critical patent/FR2369248B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/57581—Thymosin; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

La présente invention concerne un polypeptide acide présent dans la fraction de thymosine 5. Il s'agit de la thymosine alpha 1 caractérisé par la séquence (N-Acétyl) - Ser - Asp - Ala - Ala - Val - Asp - Thr - Ser - Ser - Glu -Ile - Thr - Thr - Lys - Asp - Leu - Lys - Glu - Lys -Lys - Glu - Val - Val - Glu - Glu - Ala - Glu - Asn - OH et de ses sels utilisables en pharmacie, exempts d'autres polypeptides du thymus. Ces composés sont utiles comme médicaments.The present invention relates to an acidic polypeptide present in the thymosin 5 fraction. It is thymosin alpha 1 characterized by the sequence (N-Acetyl) - Ser - Asp - Ala - Ala - Val - Asp - Thr - Ser - Ser - Glu -Ile - Thr - Thr - Lys - Asp - Leu - Lys - Glu - Lys -Lys - Glu - Val - Val - Glu - Glu - Ala - Glu - Asn - OH and its salts which can be used in pharmacy, free other thymus polypeptides. These compounds are useful as drugs.

FR7732259A 1976-10-28 1977-10-26 THYMOSIN USEFUL AS A MEDICINAL PRODUCT AND ITS PREPARATION PROCESS Granted FR2369248A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US73663876A 1976-10-28 1976-10-28
US05/766,638 US4079127A (en) 1976-10-28 1977-02-08 Thymosin alpha 1

Publications (2)

Publication Number Publication Date
FR2369248A1 true FR2369248A1 (en) 1978-05-26
FR2369248B1 FR2369248B1 (en) 1981-01-02

Family

ID=27113070

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7732259A Granted FR2369248A1 (en) 1976-10-28 1977-10-26 THYMOSIN USEFUL AS A MEDICINAL PRODUCT AND ITS PREPARATION PROCESS

Country Status (22)

Country Link
JP (1) JPS5411220A (en)
AR (1) AR214903A1 (en)
AT (1) AT362493B (en)
AU (1) AU514996B2 (en)
CA (1) CA1101842A (en)
CH (1) CH633258A5 (en)
DE (1) DE2748213A1 (en)
DK (1) DK149094C (en)
ES (1) ES463588A1 (en)
FI (1) FI56317C (en)
FR (1) FR2369248A1 (en)
GB (1) GB1590457A (en)
IL (1) IL53218A (en)
IT (1) IT1195254B (en)
LU (1) LU78395A1 (en)
MC (1) MC1167A1 (en)
NL (1) NL188699C (en)
NO (1) NO143346C (en)
NZ (1) NZ185519A (en)
PT (1) PT67204B (en)
SE (1) SE442479B (en)
YU (1) YU40314B (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2919592A1 (en) * 1979-05-15 1981-01-15 Max Planck Gesellschaft METHOD FOR PRODUCING THYMOSINE ALPHA 1 AND DERIVATIVES THEREOF
US4339427A (en) * 1980-04-14 1982-07-13 Hoffmann-La Roche Inc. Radioimmunoassay of thymosinα
FR2492663B1 (en) * 1980-10-24 1985-11-08 Vtoroi Mo G MEDICINAL PRODUCT REGULATING THE IMMUNITY T-SYSTEM AND ITS PREPARATION METHOD
DE3137231A1 (en) * 1981-09-18 1983-04-14 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V., 3400 Göttingen BIS-THYMOSINE (ALPHA) (DOWN ARROW) 1 (DOWN ARROW) CONNECTIONS
JPH01250018A (en) * 1988-03-30 1989-10-05 Noble Sangyo Kk Displacement detector electronic measuring instrument

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1605258A (en) * 1966-08-24 1973-11-30 Hormone like preparations from thymus - gland

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1605258A (en) * 1966-08-24 1973-11-30 Hormone like preparations from thymus - gland

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
CA1975 *
CA1977 *

Also Published As

Publication number Publication date
JPS618805B2 (en) 1986-03-18
NO143346C (en) 1981-01-21
IL53218A (en) 1981-03-31
FR2369248B1 (en) 1981-01-02
YU257877A (en) 1983-01-21
IL53218A0 (en) 1977-12-30
DK149094B (en) 1986-01-20
FI56317B (en) 1979-09-28
FI773221A (en) 1978-04-29
NL188699B (en) 1992-04-01
PT67204A (en) 1977-11-01
NL188699C (en) 1992-09-01
ES463588A1 (en) 1978-12-16
NO143346B (en) 1980-10-13
JPS5411220A (en) 1979-01-27
CA1101842A (en) 1981-05-26
SE442479B (en) 1986-01-13
DE2748213A1 (en) 1978-05-11
NO773681L (en) 1978-05-02
SE7712071L (en) 1978-04-29
ATA765877A (en) 1980-10-15
AR214903A1 (en) 1979-08-15
DK149094C (en) 1986-06-16
NZ185519A (en) 1980-08-26
AU2969977A (en) 1979-04-26
AU514996B2 (en) 1981-03-12
IT1195254B (en) 1988-10-12
MC1167A1 (en) 1978-06-02
PT67204B (en) 1979-11-12
DK478277A (en) 1978-04-29
DE2748213C2 (en) 1988-06-30
FI56317C (en) 1980-01-10
YU40314B (en) 1985-12-31
AT362493B (en) 1981-05-25
LU78395A1 (en) 1979-02-02
GB1590457A (en) 1981-06-03
NL7711814A (en) 1978-05-03
CH633258A5 (en) 1982-11-30

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Legal Events

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