ES463588A1 - A METHOD FOR THE PREPARATION OF ALPHA THYMOSINE 1. - Google Patents

A METHOD FOR THE PREPARATION OF ALPHA THYMOSINE 1.

Info

Publication number
ES463588A1
ES463588A1 ES463588A ES463588A ES463588A1 ES 463588 A1 ES463588 A1 ES 463588A1 ES 463588 A ES463588 A ES 463588A ES 463588 A ES463588 A ES 463588A ES 463588 A1 ES463588 A1 ES 463588A1
Authority
ES
Spain
Prior art keywords
preparation
buffer
thymosine
alpha
thymosin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES463588A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Hoffmann La Roche Inc
University of Texas System
University of Texas at Austin
Original Assignee
F Hoffmann La Roche AG
Hoffmann La Roche Inc
University of Texas System
University of Texas at Austin
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/766,638 external-priority patent/US4079127A/en
Application filed by F Hoffmann La Roche AG, Hoffmann La Roche Inc, University of Texas System, University of Texas at Austin filed Critical F Hoffmann La Roche AG
Publication of ES463588A1 publication Critical patent/ES463588A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/57581—Thymosin; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Un método para la preparación de timosina alfa1 a partir de la fracción timosínica 5, caracterizado porque comprenden en su realización, el cromatografiar la fracción timosínica 5, liofilizada, sobre una columna de carboximetil-celulosa en un tampón de acetato sódico/2-mercaptoetanol de pH 5,0, lavar la columna primero con este tampón y luego eluirla con un gradiente lineal de dicho tampón y dicho tampón más NaCl 1,0 M.A method for the preparation of thymosin alpha1 from the thymosin fraction 5, characterized in that it comprises, in its performance, chromatographing the thymosin fraction 5, lyophilized, on a column of carboxymethyl-cellulose in a buffer of sodium acetate / 2-mercaptoethanol of pH 5.0, wash the column first with this buffer and then elute with a linear gradient of said buffer and said buffer plus 1.0 M NaCl.

ES463588A 1976-10-28 1977-10-27 A METHOD FOR THE PREPARATION OF ALPHA THYMOSINE 1. Expired ES463588A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US73663876A 1976-10-28 1976-10-28
US05/766,638 US4079127A (en) 1976-10-28 1977-02-08 Thymosin alpha 1

Publications (1)

Publication Number Publication Date
ES463588A1 true ES463588A1 (en) 1978-12-16

Family

ID=27113070

Family Applications (1)

Application Number Title Priority Date Filing Date
ES463588A Expired ES463588A1 (en) 1976-10-28 1977-10-27 A METHOD FOR THE PREPARATION OF ALPHA THYMOSINE 1.

Country Status (22)

Country Link
JP (1) JPS5411220A (en)
AR (1) AR214903A1 (en)
AT (1) AT362493B (en)
AU (1) AU514996B2 (en)
CA (1) CA1101842A (en)
CH (1) CH633258A5 (en)
DE (1) DE2748213A1 (en)
DK (1) DK149094C (en)
ES (1) ES463588A1 (en)
FI (1) FI56317C (en)
FR (1) FR2369248A1 (en)
GB (1) GB1590457A (en)
IL (1) IL53218A (en)
IT (1) IT1195254B (en)
LU (1) LU78395A1 (en)
MC (1) MC1167A1 (en)
NL (1) NL188699C (en)
NO (1) NO143346C (en)
NZ (1) NZ185519A (en)
PT (1) PT67204B (en)
SE (1) SE442479B (en)
YU (1) YU40314B (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2919592A1 (en) * 1979-05-15 1981-01-15 Max Planck Gesellschaft METHOD FOR PRODUCING THYMOSINE ALPHA 1 AND DERIVATIVES THEREOF
US4339427A (en) * 1980-04-14 1982-07-13 Hoffmann-La Roche Inc. Radioimmunoassay of thymosinα
FR2492663B1 (en) * 1980-10-24 1985-11-08 Vtoroi Mo G MEDICINAL PRODUCT REGULATING THE IMMUNITY T-SYSTEM AND ITS PREPARATION METHOD
DE3137231A1 (en) * 1981-09-18 1983-04-14 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V., 3400 Göttingen BIS-THYMOSINE (ALPHA) (DOWN ARROW) 1 (DOWN ARROW) CONNECTIONS
JPH01250018A (en) * 1988-03-30 1989-10-05 Noble Sangyo Kk Displacement detector electronic measuring instrument

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1195980A (en) * 1966-08-24 1970-06-24 Univ Yeshiva Hormone-Like Preparations Derived from Thymus Gland and Methods of Producing the Same.

Also Published As

Publication number Publication date
DK149094B (en) 1986-01-20
SE7712071L (en) 1978-04-29
IL53218A0 (en) 1977-12-30
FI56317C (en) 1980-01-10
AT362493B (en) 1981-05-25
DE2748213A1 (en) 1978-05-11
CA1101842A (en) 1981-05-26
PT67204A (en) 1977-11-01
NL188699B (en) 1992-04-01
JPS5411220A (en) 1979-01-27
DK478277A (en) 1978-04-29
GB1590457A (en) 1981-06-03
IL53218A (en) 1981-03-31
NO773681L (en) 1978-05-02
AU2969977A (en) 1979-04-26
NL7711814A (en) 1978-05-03
SE442479B (en) 1986-01-13
JPS618805B2 (en) 1986-03-18
DK149094C (en) 1986-06-16
YU40314B (en) 1985-12-31
AR214903A1 (en) 1979-08-15
DE2748213C2 (en) 1988-06-30
LU78395A1 (en) 1979-02-02
CH633258A5 (en) 1982-11-30
FR2369248B1 (en) 1981-01-02
YU257877A (en) 1983-01-21
IT1195254B (en) 1988-10-12
AU514996B2 (en) 1981-03-12
NZ185519A (en) 1980-08-26
FR2369248A1 (en) 1978-05-26
NO143346B (en) 1980-10-13
NL188699C (en) 1992-09-01
NO143346C (en) 1981-01-21
MC1167A1 (en) 1978-06-02
PT67204B (en) 1979-11-12
ATA765877A (en) 1980-10-15
FI56317B (en) 1979-09-28
FI773221A7 (en) 1978-04-29

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