FR2366309A1 - Procede de preparation d'un aminocyclitol antibiotique du type streptamine, desoxystreptamine ou didesoxystreptamine - Google Patents

Procede de preparation d'un aminocyclitol antibiotique du type streptamine, desoxystreptamine ou didesoxystreptamine

Info

Publication number
FR2366309A1
FR2366309A1 FR7725953A FR7725953A FR2366309A1 FR 2366309 A1 FR2366309 A1 FR 2366309A1 FR 7725953 A FR7725953 A FR 7725953A FR 7725953 A FR7725953 A FR 7725953A FR 2366309 A1 FR2366309 A1 FR 2366309A1
Authority
FR
France
Prior art keywords
streptamine
aminocyclitol
antibiotic
preparing
type
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7725953A
Other languages
English (en)
Other versions
FR2366309B1 (fr
Inventor
Sol Jacob Daum
Robert La Grone Clarke
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
STWB Inc
Original Assignee
Sterling Drug Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sterling Drug Inc filed Critical Sterling Drug Inc
Publication of FR2366309A1 publication Critical patent/FR2366309A1/fr
Application granted granted Critical
Publication of FR2366309B1 publication Critical patent/FR2366309B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
    • C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
    • C07H15/234—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2
    • C07H15/236—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2 a saccharide radical being substituted by an alkylamino radical in position 3 and by two substituents different from hydrogen in position 4, e.g. gentamicin complex, sisomicin, verdamycin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/14—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by free hydroxyl radicals
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/863—Mycobacterium
    • Y10S435/865—Mycobacterium fortuitum

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Procédé de préparation d'un aminocyclitol antibiotique du type streptamine désoxystreptamine ou didésoxystreptamine, caractérisé en ce qu'on cultive un milieu nutritif contenant des glucides, une source d'azote assimilable, des sels essentiels, et un cyclitol de la catégorie des 2,R2 '-5-R5 '-3,4,6-trihydroxycyclohexanones ou des 2-R2 '-5-R5 '-1,3,4,6-tétrahydroxycyclohexanes représentés par la formule IIIa :
FR7725953A 1975-09-22 1977-08-25 Procede de preparation d'un aminocyclitol antibiotique du type streptamine, desoxystreptamine ou didesoxystreptamine Granted FR2366309A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/615,593 US3982996A (en) 1975-09-22 1975-09-22 Process for preparing aminocyclitol antibiotics

Publications (2)

Publication Number Publication Date
FR2366309A1 true FR2366309A1 (fr) 1978-04-28
FR2366309B1 FR2366309B1 (fr) 1981-05-29

Family

ID=24466060

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7725953A Granted FR2366309A1 (fr) 1975-09-22 1977-08-25 Procede de preparation d'un aminocyclitol antibiotique du type streptamine, desoxystreptamine ou didesoxystreptamine

Country Status (6)

Country Link
US (1) US3982996A (fr)
FR (1) FR2366309A1 (fr)
GB (1) GB1543518A (fr)
NO (1) NO146141C (fr)
PH (1) PH16042A (fr)
SE (1) SE8007539L (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4053591A (en) * 1976-06-30 1977-10-11 Schering Corporation 5-deoxy-4,6-di-o-(aminoglycosyl)-1,3-diaminocyclitols, methods for their manufacture, method for their use as antibacterial agents and compositions useful therefor
JPS6030320B2 (ja) * 1978-01-13 1985-07-16 山之内製薬株式会社 新規抗生物質およびその製造法
US4387219A (en) * 1979-11-13 1983-06-07 Sterling Drug Inc. 2-Hydroxy gentamicin compounds
US4288547A (en) * 1979-11-13 1981-09-08 Haruo Yamamoto Fermentative process for preparing antibiotics of the gentamicin class
US4412068A (en) * 1981-06-08 1983-10-25 Sterling Drug Inc. Novel compounds of the gentamicin class
JP3602854B2 (ja) * 1997-06-13 2004-12-15 タカラバイオ株式会社 ヒドロキシシクロペンタノン
CN102942603B (zh) * 2006-06-02 2016-01-20 明治制果药业株式会社 新的氨基糖苷类抗生素

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3541078A (en) * 1968-05-15 1970-11-17 Parke Davis & Co Amine compounds and methods for their production
US3669838A (en) * 1970-03-17 1972-06-13 Univ Illinois Method of making antibiotics containing the aminocyclitol subunit

Also Published As

Publication number Publication date
US3982996A (en) 1976-09-28
SE8007539L (sv) 1980-10-27
PH16042A (en) 1983-06-02
FR2366309B1 (fr) 1981-05-29
NO803186L (no) 1976-08-19
NO146141C (no) 1982-08-11
NO146141B (no) 1982-04-26
GB1543518A (en) 1979-04-04

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Legal Events

Date Code Title Description
ST Notification of lapse