FR2364216A1 - Derives de la clavuline et leur procede de preparation - Google Patents
Derives de la clavuline et leur procede de preparationInfo
- Publication number
- FR2364216A1 FR2364216A1 FR7727250A FR7727250A FR2364216A1 FR 2364216 A1 FR2364216 A1 FR 2364216A1 FR 7727250 A FR7727250 A FR 7727250A FR 7727250 A FR7727250 A FR 7727250A FR 2364216 A1 FR2364216 A1 FR 2364216A1
- Authority
- FR
- France
- Prior art keywords
- beta
- clavulanic acid
- clavam
- acid derivs
- antibiotics
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- HZZVJAQRINQKSD-UHFFFAOYSA-N Clavulanic acid Natural products OC(=O)C1C(=CCO)OC2CC(=O)N21 HZZVJAQRINQKSD-UHFFFAOYSA-N 0.000 title abstract 3
- HZZVJAQRINQKSD-PBFISZAISA-N clavulanic acid Chemical compound OC(=O)[C@H]1C(=C/CO)/O[C@@H]2CC(=O)N21 HZZVJAQRINQKSD-PBFISZAISA-N 0.000 title abstract 3
- 229960003324 clavulanic acid Drugs 0.000 title abstract 3
- 239000003242 anti bacterial agent Substances 0.000 title 1
- 229940088710 antibiotic agent Drugs 0.000 title 1
- 239000003781 beta lactamase inhibitor Substances 0.000 title 1
- 229940126813 beta-lactamase inhibitor Drugs 0.000 title 1
- 102000006635 beta-lactamase Human genes 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 108020004256 Beta-lactamase Proteins 0.000 abstract 1
- 229930186147 Cephalosporin Natural products 0.000 abstract 1
- 108090000204 Dipeptidase 1 Proteins 0.000 abstract 1
- 241000588697 Enterobacter cloacae Species 0.000 abstract 1
- 229930182555 Penicillin Natural products 0.000 abstract 1
- 229940124587 cephalosporin Drugs 0.000 abstract 1
- 150000001780 cephalosporins Chemical class 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 125000000896 monocarboxylic acid group Chemical group 0.000 abstract 1
- 230000000269 nucleophilic effect Effects 0.000 abstract 1
- 125000006503 p-nitrobenzyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1[N+]([O-])=O)C([H])([H])* 0.000 abstract 1
- 150000002960 penicillins Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
L'invention Concerne des dérivés de la clavuline. Les composés conformes à l'invention répondent à la formule suivant.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB37482/76A GB1591438A (en) | 1976-09-09 | 1976-09-09 | Clavem derivatives |
GB3748276 | 1976-09-09 |
Publications (1)
Publication Number | Publication Date |
---|---|
FR2364216A1 true FR2364216A1 (fr) | 1978-04-07 |
Family
ID=26263451
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR7727250A Withdrawn FR2364216A1 (fr) | 1976-09-09 | 1977-09-08 | Derives de la clavuline et leur procede de preparation |
Country Status (4)
Country | Link |
---|---|
JP (1) | JPS5359690A (fr) |
DE (1) | DE2740526A1 (fr) |
FR (1) | FR2364216A1 (fr) |
NL (1) | NL7709876A (fr) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2364205A1 (fr) * | 1976-09-09 | 1978-04-07 | Glaxo Lab Ltd | Nouvelles betaines monocycliques et leur procede de preparation |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS54117459A (en) * | 1978-01-20 | 1979-09-12 | Glaxo Group Ltd | Novel lactam compound |
GB2045236A (en) * | 1979-03-26 | 1980-10-29 | Hoechst Uk Ltd | Oxapenem derivatives |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2289188A1 (fr) * | 1974-10-28 | 1976-05-28 | Beecham Group Ltd | Azetidinones substituees a activite antibacterienne |
FR2335221A1 (fr) * | 1975-12-16 | 1977-07-15 | Beecham Group Ltd | Composes renfermant un cycle b-lactame, utilisables comme medicament |
FR2335222A1 (fr) * | 1975-12-17 | 1977-07-15 | Glaxo Lab Ltd | Derives etherifies de l'acide clavulanique, leur preparation et compositions therapeutiques en contenant |
FR2336130A1 (fr) * | 1975-04-14 | 1977-07-22 | Beecham Group Ltd | Composes utilisables dans le traitement des infections bacteriennes |
-
1977
- 1977-09-08 FR FR7727250A patent/FR2364216A1/fr not_active Withdrawn
- 1977-09-08 DE DE19772740526 patent/DE2740526A1/de not_active Withdrawn
- 1977-09-08 JP JP10870877A patent/JPS5359690A/ja active Pending
- 1977-09-08 NL NL7709876A patent/NL7709876A/xx not_active Application Discontinuation
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2289188A1 (fr) * | 1974-10-28 | 1976-05-28 | Beecham Group Ltd | Azetidinones substituees a activite antibacterienne |
FR2336130A1 (fr) * | 1975-04-14 | 1977-07-22 | Beecham Group Ltd | Composes utilisables dans le traitement des infections bacteriennes |
FR2335221A1 (fr) * | 1975-12-16 | 1977-07-15 | Beecham Group Ltd | Composes renfermant un cycle b-lactame, utilisables comme medicament |
FR2335222A1 (fr) * | 1975-12-17 | 1977-07-15 | Glaxo Lab Ltd | Derives etherifies de l'acide clavulanique, leur preparation et compositions therapeutiques en contenant |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2364205A1 (fr) * | 1976-09-09 | 1978-04-07 | Glaxo Lab Ltd | Nouvelles betaines monocycliques et leur procede de preparation |
Also Published As
Publication number | Publication date |
---|---|
DE2740526A1 (de) | 1978-03-16 |
NL7709876A (nl) | 1978-03-13 |
JPS5359690A (en) | 1978-05-29 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
ST | Notification of lapse |