FR2362630A1 - (4)-Amino-(6,7)-dimethoxy-piperidino or alkylene-diamino quinazolines - are antihypertensives with no undesirable side-effects - Google Patents

(4)-Amino-(6,7)-dimethoxy-piperidino or alkylene-diamino quinazolines - are antihypertensives with no undesirable side-effects

Info

Publication number
FR2362630A1
FR2362630A1 FR7625563A FR7625563A FR2362630A1 FR 2362630 A1 FR2362630 A1 FR 2362630A1 FR 7625563 A FR7625563 A FR 7625563A FR 7625563 A FR7625563 A FR 7625563A FR 2362630 A1 FR2362630 A1 FR 2362630A1
Authority
FR
France
Prior art keywords
antihypertensives
piperidino
dimethoxy
alkylene
amino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7625563A
Other languages
French (fr)
Other versions
FR2362630B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Synthelabo SA
Original Assignee
Synthelabo SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synthelabo SA filed Critical Synthelabo SA
Priority to FR7625563A priority Critical patent/FR2362630A1/en
Priority to DK199277A priority patent/DK140695C/en
Priority to ES77458557A priority patent/ES458557A1/en
Priority to LU77283A priority patent/LU77283A1/xx
Priority to DE2720545A priority patent/DE2720545C3/en
Priority to AT325777A priority patent/AT356113B/en
Priority to PT66526A priority patent/PT66526B/en
Priority to NLAANVRAGE7704979,A priority patent/NL188527C/en
Priority to IL52041A priority patent/IL52041A/en
Priority to AU24975/77A priority patent/AU506410B2/en
Priority to SE7705310A priority patent/SE432250B/en
Priority to GR53393A priority patent/GR63196B/en
Priority to CA277,884A priority patent/CA1056831A/en
Priority to GB19223/77A priority patent/GB1530768A/en
Priority to IE921/77A priority patent/IE45051B1/en
Priority to FI771447A priority patent/FI771447A/fi
Priority to CH570977A priority patent/CH599193A5/xx
Priority to NO771610A priority patent/NO771610L/en
Priority to US05/795,375 priority patent/US4341893A/en
Priority to NZ184050A priority patent/NZ184050A/en
Publication of FR2362630A1 publication Critical patent/FR2362630A1/en
Application granted granted Critical
Publication of FR2362630B1 publication Critical patent/FR2362630B1/fr
Priority to AT473379A priority patent/AT357165B/en
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Quinazoline derivs. of formula (I) and their acid addn. salts are novel cpds. (where A is or -NR2-CnH2n-NR3 n=2,3 or 4; R2,R3 are each H or 1-4C alkyl and R is phenyl (opt. substd. by one or more gps. chosen from 1-4C alkyl, 1-4C alkoxy, and methylenedioxy), furyl thienyl or 5-alkylthio-1,3,4-oxadiazole-2-yl. (I) have marked antihypertensive activity of prolonged duration. The oral LD50 in mice is >500 mg/kg and i.p. LD50 in rats is generally >500 mg/kg. The cpds. do not affect cardiac rhythm and may be used to treat all types of hypertension by oral, rectal or parteral administration.
FR7625563A 1976-05-07 1976-08-24 (4)-Amino-(6,7)-dimethoxy-piperidino or alkylene-diamino quinazolines - are antihypertensives with no undesirable side-effects Granted FR2362630A1 (en)

Priority Applications (21)

Application Number Priority Date Filing Date Title
FR7625563A FR2362630A1 (en) 1976-08-24 1976-08-24 (4)-Amino-(6,7)-dimethoxy-piperidino or alkylene-diamino quinazolines - are antihypertensives with no undesirable side-effects
DK199277A DK140695C (en) 1976-05-07 1977-05-05 ANALOGY PROCEDURE FOR PREPARING 2,4-DIAMINO-6,7-DIMETHOXYQUINAZOLINE DERIVATIVES OR ACID ADDITION SALTS
GB19223/77A GB1530768A (en) 1976-05-07 1977-05-06 2-substituted-4-amino-6,7-dimethoxyquinazolines
DE2720545A DE2720545C3 (en) 1976-05-07 1977-05-06 Derivatives of 2,4-diamino-6,7-dimethoxyquinazoline, their preparation and pharmaceutical agents
AT325777A AT356113B (en) 1976-08-24 1977-05-06 METHOD FOR PRODUCING NEW CHINAZOLINE DERIVATIVES AND THEIR SALTS
PT66526A PT66526B (en) 1976-05-07 1977-05-06 PROCESS FOR THE PREPARATION OF QUINAZOLINE DERIVATIVES
NLAANVRAGE7704979,A NL188527C (en) 1976-05-07 1977-05-06 METHOD FOR PREPARING A MEDICINAL PRODUCT CONTAINING A DIMETHOXYCHINAZOLINE, FORMED MEDICINAL PRODUCT WITH ANTI-BLOOD PRESSURE EFFECT AND METHOD FOR PREPARING THE ACTIVE SUBSTANCE
IL52041A IL52041A (en) 1976-05-07 1977-05-06 Quinazoline derivatives,their preparation and pharmaceutical compositions containing them
AU24975/77A AU506410B2 (en) 1976-05-07 1977-05-06 Quinazoline derivatives
SE7705310A SE432250B (en) 1976-05-07 1977-05-06 PROCEDURE FOR PREPARING A CHINAZOLINE DERIVATIVE
ES77458557A ES458557A1 (en) 1976-05-07 1977-05-06 Quinazoline derivatives
CA277,884A CA1056831A (en) 1976-05-07 1977-05-06 Quinazoline derivatives
LU77283A LU77283A1 (en) 1976-05-07 1977-05-06
IE921/77A IE45051B1 (en) 1976-05-07 1977-05-06 2-substituted-4-amino-6,7-dimethoxy-quinazolines
FI771447A FI771447A (en) 1976-05-07 1977-05-06
CH570977A CH599193A5 (en) 1976-05-07 1977-05-06
NO771610A NO771610L (en) 1976-05-07 1977-05-06 PROCEDURES FOR THE PREPARATION OF KINAZOLIN DERIVATIVES
GR53393A GR63196B (en) 1976-05-07 1977-05-06 Preparation process of quinazoline derivatives
US05/795,375 US4341893A (en) 1976-05-07 1977-05-09 Quinazoline derivatives
NZ184050A NZ184050A (en) 1976-05-07 1977-05-09 2-substituted amino-4-amono-6,7-demethoxy-quinzaolines
AT473379A AT357165B (en) 1976-08-24 1979-07-06 METHOD FOR PRODUCING NEW CHINA ZOLINE DERIVATIVES AND THEIR SALTS

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7625563A FR2362630A1 (en) 1976-08-24 1976-08-24 (4)-Amino-(6,7)-dimethoxy-piperidino or alkylene-diamino quinazolines - are antihypertensives with no undesirable side-effects

Publications (2)

Publication Number Publication Date
FR2362630A1 true FR2362630A1 (en) 1978-03-24
FR2362630B1 FR2362630B1 (en) 1979-03-02

Family

ID=9177092

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7625563A Granted FR2362630A1 (en) 1976-05-07 1976-08-24 (4)-Amino-(6,7)-dimethoxy-piperidino or alkylene-diamino quinazolines - are antihypertensives with no undesirable side-effects

Country Status (2)

Country Link
AT (1) AT356113B (en)
FR (1) FR2362630A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2421888A1 (en) * 1978-02-06 1979-11-02 Synthelabo ALKYLENE DIAMINE AMIDES AND THEIR APPLICATION IN THERAPEUTICS

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
NEANT *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2421888A1 (en) * 1978-02-06 1979-11-02 Synthelabo ALKYLENE DIAMINE AMIDES AND THEIR APPLICATION IN THERAPEUTICS
FR2445323A2 (en) * 1978-02-06 1980-07-25 Synthelabo ALKYLENEDIAMINE AMIDES AND THEIR THERAPEUTIC APPLICATION

Also Published As

Publication number Publication date
ATA325777A (en) 1979-09-15
AT356113B (en) 1980-04-10
FR2362630B1 (en) 1979-03-02

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Legal Events

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