FR2359851A1 - ANTIGEN AND ANTIBODIES FOR AN TEST FOR THE IMMUNOLOGICAL DETERMINATION OF THYMOPOIETIN, AND THEIR APPLICATION - Google Patents
ANTIGEN AND ANTIBODIES FOR AN TEST FOR THE IMMUNOLOGICAL DETERMINATION OF THYMOPOIETIN, AND THEIR APPLICATIONInfo
- Publication number
- FR2359851A1 FR2359851A1 FR7723092A FR7723092A FR2359851A1 FR 2359851 A1 FR2359851 A1 FR 2359851A1 FR 7723092 A FR7723092 A FR 7723092A FR 7723092 A FR7723092 A FR 7723092A FR 2359851 A1 FR2359851 A1 FR 2359851A1
- Authority
- FR
- France
- Prior art keywords
- thymopoietin
- test
- antigen
- antibodies
- application
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102100023981 Lamina-associated polypeptide 2, isoform alpha Human genes 0.000 title abstract 3
- 101710163560 Lamina-associated polypeptide 2, isoform alpha Proteins 0.000 title abstract 3
- 101710189385 Lamina-associated polypeptide 2, isoforms beta/gamma Proteins 0.000 title abstract 3
- 239000000898 Thymopoietin Substances 0.000 title abstract 3
- 239000000427 antigen Substances 0.000 title abstract 2
- 102000036639 antigens Human genes 0.000 title abstract 2
- 108091007433 antigens Proteins 0.000 title abstract 2
- 230000001900 immune effect Effects 0.000 title 1
- 238000003018 immunoassay Methods 0.000 abstract 2
- 210000002966 serum Anatomy 0.000 abstract 2
- 206010020751 Hypersensitivity Diseases 0.000 abstract 1
- 208000002720 Malnutrition Diseases 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 102000015731 Peptide Hormones Human genes 0.000 abstract 1
- 108010038988 Peptide Hormones Proteins 0.000 abstract 1
- 208000026935 allergic disease Diseases 0.000 abstract 1
- 230000007815 allergy Effects 0.000 abstract 1
- 210000001124 body fluid Anatomy 0.000 abstract 1
- 239000010839 body fluid Substances 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- 238000003745 diagnosis Methods 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000005556 hormone Substances 0.000 abstract 1
- 229940088597 hormone Drugs 0.000 abstract 1
- 230000002163 immunogen Effects 0.000 abstract 1
- 206010025135 lupus erythematosus Diseases 0.000 abstract 1
- 230000001071 malnutrition Effects 0.000 abstract 1
- 235000000824 malnutrition Nutrition 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 206010028417 myasthenia gravis Diseases 0.000 abstract 1
- 208000015380 nutritional deficiency disease Diseases 0.000 abstract 1
- 239000000813 peptide hormone Substances 0.000 abstract 1
- 206010039073 rheumatoid arthritis Diseases 0.000 abstract 1
- 210000001541 thymus gland Anatomy 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
- G01N33/532—Production of labelled immunochemicals
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
- G01N33/537—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with separation of immune complex from unbound antigen or antibody
Landscapes
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Food Science & Technology (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
L'invention décrit les réactifs et le mode opératoire d'un essai immunologique de détermination de la thymopoïétine, hormone polypeptidique du thymus. On prepare un anticorps spécifique de la thymopoïétine en inoculant à un hôte animal un antigène obtenu par fixation de la thypopoïétine sur une matière immunogène de support. Le sérum collecté de cet animal est un anticorps que l'on utilisera dans l'essai immunologique. Cet essai peut servir à déterminer les taux de l'hormone dans des fluides biologiques (plasma ou sérum), pour un diagnostic ou pour suivre le traitement de la myasthénie grave (taux éleves) ou de maladies comme l'arthrite rhumatoïde, du lupus érythémateux, une allergie, un cancer ou de la malnutrition (taux réduits).The invention describes the reagents and the procedure of an immunoassay for the determination of thymopoietin, a polypeptide hormone of the thymus. An antibody specific for thymopoietin is prepared by inoculating an animal host with an antigen obtained by binding of thypopoietin to a supporting immunogenic material. The serum collected from this animal is an antibody which will be used in the immunoassay. This test can be used to determine the levels of the hormone in body fluids (plasma or serum), for diagnosis or to follow the treatment of myasthenia gravis (high levels) or of diseases such as rheumatoid arthritis, lupus erythematosus. , allergy, cancer or malnutrition (reduced rates).
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US05/709,565 US4055633A (en) | 1976-07-28 | 1976-07-28 | Immunoassay for thymopoietin |
| US05/810,269 US4124700A (en) | 1976-07-28 | 1977-06-27 | Immunoassay for thymopoietin |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2359851A1 true FR2359851A1 (en) | 1978-02-24 |
| FR2359851B1 FR2359851B1 (en) | 1983-04-01 |
Family
ID=27108277
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR7723092A Granted FR2359851A1 (en) | 1976-07-28 | 1977-07-27 | ANTIGEN AND ANTIBODIES FOR AN TEST FOR THE IMMUNOLOGICAL DETERMINATION OF THYMOPOIETIN, AND THEIR APPLICATION |
Country Status (9)
| Country | Link |
|---|---|
| JP (1) | JPS6012576B2 (en) |
| AU (1) | AU497627B1 (en) |
| CA (1) | CA1075600A (en) |
| DE (1) | DE2733561C3 (en) |
| FR (1) | FR2359851A1 (en) |
| GB (1) | GB1545332A (en) |
| IT (1) | IT1126757B (en) |
| NZ (1) | NZ184667A (en) |
| SE (1) | SE447165B (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2557458A1 (en) * | 1983-12-30 | 1985-07-05 | Centre Nat Rech Scient | NOVEL ANTIBODIES CAPABLE OF SPECIFICALLY RECOGNIZING HAPTEN GROUPS, PREPARATION AND APPLICATION THEREOF, AND NOVEL ANTIGENS FOR PREPARING THEM |
| FR2581313A1 (en) * | 1985-05-02 | 1986-11-07 | Pasteur Institut | COMPOUNDS FOR ANTIBODY FORMATION, IMMUNOGENIC COMPOSITIONS AND IMMUNOPROTECTIVE COMPOSITIONS CONTAINING SAME, AND METHOD FOR OBTAINING ANTIBODIES USING SAME |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2160312B (en) * | 1984-04-13 | 1987-09-16 | South African Inventions | Adjuvant for immunisation |
| US5593842A (en) * | 1994-09-20 | 1997-01-14 | Gideon Goldstein | Method of measuring thymopoietin proteins in plasma and serum including acidification of the plasma and serum |
-
1977
- 1977-07-15 CA CA282,819A patent/CA1075600A/en not_active Expired
- 1977-07-18 NZ NZ18466777A patent/NZ184667A/en unknown
- 1977-07-19 GB GB3017777A patent/GB1545332A/en not_active Expired
- 1977-07-26 DE DE19772733561 patent/DE2733561C3/en not_active Expired
- 1977-07-26 IT IT5044677A patent/IT1126757B/en active
- 1977-07-27 AU AU27382/77A patent/AU497627B1/en not_active Expired
- 1977-07-27 SE SE7708625A patent/SE447165B/en not_active IP Right Cessation
- 1977-07-27 FR FR7723092A patent/FR2359851A1/en active Granted
- 1977-07-27 JP JP9021277A patent/JPS6012576B2/en not_active Expired
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2557458A1 (en) * | 1983-12-30 | 1985-07-05 | Centre Nat Rech Scient | NOVEL ANTIBODIES CAPABLE OF SPECIFICALLY RECOGNIZING HAPTEN GROUPS, PREPARATION AND APPLICATION THEREOF, AND NOVEL ANTIGENS FOR PREPARING THEM |
| EP0149405A2 (en) * | 1983-12-30 | 1985-07-24 | Etablissement Public dit: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) | Antibodies capable of specifically recognizing haptenic groups, their preparation and application, and antigens for the preparation of these antibodies |
| EP0149405A3 (en) * | 1983-12-30 | 1985-08-14 | Etablissement Public dit: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) | Antibodies capable of specifically recognizing haptenic groups, their preparation and application, and antigens for the preparation of these antibodies |
| FR2581313A1 (en) * | 1985-05-02 | 1986-11-07 | Pasteur Institut | COMPOUNDS FOR ANTIBODY FORMATION, IMMUNOGENIC COMPOSITIONS AND IMMUNOPROTECTIVE COMPOSITIONS CONTAINING SAME, AND METHOD FOR OBTAINING ANTIBODIES USING SAME |
| EP0201413A1 (en) * | 1985-05-02 | 1986-12-17 | INSTITUT PASTEUR Fondation reconnue d'utilité publique | Compounds causing the production of antibodies, immunogenic and immunoprotective compositions containing them, and process for obtaining antibodies by using them |
Also Published As
| Publication number | Publication date |
|---|---|
| IT1126757B (en) | 1986-05-21 |
| GB1545332A (en) | 1979-05-10 |
| SE7708625L (en) | 1978-01-29 |
| DE2733561C3 (en) | 1980-04-03 |
| JPS6012576B2 (en) | 1985-04-02 |
| NZ184667A (en) | 1980-02-21 |
| FR2359851B1 (en) | 1983-04-01 |
| CA1075600A (en) | 1980-04-15 |
| JPS5459318A (en) | 1979-05-12 |
| AU497627B1 (en) | 1978-12-21 |
| DE2733561B2 (en) | 1979-07-26 |
| SE447165B (en) | 1986-10-27 |
| DE2733561A1 (en) | 1978-02-02 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Panush et al. | Serum and synovial fluid IgG, IgA and IgM antigammaglobulins in rheumatoid arthritis | |
| DE69214657D1 (en) | VACCINE AGAINST AND DIAGNOSTIC METHOD FOR THE PIG INFERTILITY AND BREATHING SYNDROME (SUAS) | |
| LV10538A (en) | Influence of immunologically binding agent on biological fluid and diagnostic agent | |
| WO1981002469A1 (en) | The solid phase anti-c3 assay for detection of immune complexes | |
| AU3615384A (en) | Method of detecting immiune complexes in serium | |
| ES8304314A1 (en) | A method and a kit for the assay of antibodies to soluble antigens. | |
| US6638723B1 (en) | Method for diagnosing autoimmune diseases | |
| Ruffatti et al. | Nuclear membrane-staining antinuclear antibody in patients with primary biliary cirrhosis | |
| ES8607024A1 (en) | Monoclonal antibodies reactive with shared idiotypes on human antibodies to native DNA from patients with systemic Lupus erythematosus. | |
| DE3780480D1 (en) | TEST FOR HUMAN BREAST CANCER. | |
| FR2359851A1 (en) | ANTIGEN AND ANTIBODIES FOR AN TEST FOR THE IMMUNOLOGICAL DETERMINATION OF THYMOPOIETIN, AND THEIR APPLICATION | |
| EP0303229A2 (en) | Method of high sensitivity immunoassay | |
| DE69123723D1 (en) | DIAGNOSTIC PROCEDURE AND REAGENT FOR HIV | |
| JP3558645B2 (en) | Use of polyclonal human anti-hTg autoantibodies as clinical diagnostics for thyroid autoimmune diseases and additives for the detection of anti-hTg autoantibodies in patient sera | |
| Ishikawa et al. | Development and applications of sensitive enzyme immunoassay for antibodies: a review | |
| ATE101439T1 (en) | PARTICLE STABILIZED EPITOPES FOR STANDARDIZATION AND CONTROL OF IMMUNOTESTS. | |
| FR2663034B1 (en) | PEPTIDES OF THE SM-D ANTIGEN AND THEIR USE IN PARTICULAR FOR THE DIAGNOSIS OF DISSEMINED LUPUS ERYTHEMATOUS. | |
| EP0109078A1 (en) | Immunochemical assay of human chorionic gonadotropin and reagent therefor | |
| EP1071956A1 (en) | Assays for autoantibodies | |
| EP0158291A3 (en) | A method for purifying carcinoembryonic antigen and a method for producing a carcinoembryonic antigen-reactive monoclonal antibody | |
| KR900017549A (en) | Cancer Serum Diagnosis | |
| RU97121066A (en) | METHOD FOR DETERMINING THE RISK OF DEVELOPMENT OF NERVOUS PSYCHOLOGICAL DISEASES | |
| DE3781808D1 (en) | DIAGNOSTIC TEST PROCEDURE FOR PIG DYSENTERIES. | |
| MX9704717A (en) | Antigen, antibodies and diagnostic assay for alzheimer's disease. | |
| GB1413800A (en) | Diagnosis of viral diseases |