FR2359135A1 - Heterocyclyl substd. phenoxy-propanolamine - with cardio:selective beta-adrenergic blocking activity - Google Patents
Heterocyclyl substd. phenoxy-propanolamine - with cardio:selective beta-adrenergic blocking activityInfo
- Publication number
- FR2359135A1 FR2359135A1 FR7720380A FR7720380A FR2359135A1 FR 2359135 A1 FR2359135 A1 FR 2359135A1 FR 7720380 A FR7720380 A FR 7720380A FR 7720380 A FR7720380 A FR 7720380A FR 2359135 A1 FR2359135 A1 FR 2359135A1
- Authority
- FR
- France
- Prior art keywords
- phenoxy
- lower alkyl
- substd
- propanolamine
- cardio
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/32—Oxygen atoms
- C07D307/33—Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/76—Unsaturated compounds containing keto groups
- C07C59/90—Unsaturated compounds containing keto groups containing singly bound oxygen-containing groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D307/10—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/12—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/40—Radicals substituted by oxygen atoms
- C07D307/42—Singly bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/40—Radicals substituted by oxygen atoms
- C07D307/46—Doubly bound oxygen atoms, or two oxygen atoms singly bound to the same carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/04—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D309/06—Radicals substituted by oxygen atoms
Abstract
Phenoxypropanolamines of formula (I) and their pharmaceutically acceptable acid addition salts are new: (m=0-3; (=2 or 3; R1=H, lower alkyl or cycloalkyl; R2 and R3 are each opt. branched lower alkyl, dimethoxylphenethyl or phenylisopropyl; R3 can also be H. R=H, halo, lower alkyl, alkoxy or cycloalkyl, allyl, nitro or acetyl. 'Lower' alkyl have 1-4C.) (I) prepd. by sequential reaction of the appropriate phenol with an epihalohydrin and HNR2R3. (I) are cardioselective beta-adrenergic blockers useful in treatment of angina pectors and arterial hypertension at 0.1-0.4g/day orally or 25-100mg/day intravenously. The intra-peritoneal LD50 in rats is 64-256mg/kg. Specifically claimed cpd. is 1-(2-chloro-4-(4-methyl-tetrahydrofuran-2-yl)- phenoxy-3-isopropylamino-2-propanol .
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB3064776 | 1976-07-22 | ||
GB5357676 | 1976-12-22 |
Publications (1)
Publication Number | Publication Date |
---|---|
FR2359135A1 true FR2359135A1 (en) | 1978-02-17 |
Family
ID=26260544
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR7720380A Withdrawn FR2359135A1 (en) | 1976-07-22 | 1977-07-01 | Heterocyclyl substd. phenoxy-propanolamine - with cardio:selective beta-adrenergic blocking activity |
Country Status (11)
Country | Link |
---|---|
JP (1) | JPS5312851A (en) |
AU (1) | AU2714177A (en) |
DE (1) | DE2733305A1 (en) |
DK (1) | DK329577A (en) |
ES (1) | ES460866A1 (en) |
FR (1) | FR2359135A1 (en) |
GR (1) | GR61995B (en) |
NL (1) | NL7707949A (en) |
NO (1) | NO772604L (en) |
PT (1) | PT66781B (en) |
SE (1) | SE7708368L (en) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS58160154U (en) * | 1983-03-01 | 1983-10-25 | セイコーエプソン株式会社 | printing device |
GB0319069D0 (en) * | 2003-08-14 | 2003-09-17 | Glaxo Group Ltd | Therapeutically useful compounds |
CA2558585C (en) | 2004-02-27 | 2010-10-12 | Amgen Inc. | Compounds, pharmaceutical compositions and methods for use in treating metabolic disorders |
US7465804B2 (en) | 2005-05-20 | 2008-12-16 | Amgen Inc. | Compounds, pharmaceutical compositions and methods for their use in treating metabolic disorders |
CA2621949A1 (en) | 2005-09-14 | 2007-03-22 | Amgen Inc. | Conformationally constrained 3- (4-hydroxy-phenyl) - substituted-propanoic acids useful for treating metabolic disorders |
US7687526B2 (en) | 2006-09-07 | 2010-03-30 | Amgen Inc. | Benzo-fused compounds for use in treating metabolic disorders |
US7714008B2 (en) | 2006-09-07 | 2010-05-11 | Amgen Inc. | Heterocyclic GPR40 modulators |
US7572934B2 (en) | 2007-04-16 | 2009-08-11 | Amgen Inc. | Substituted biphenyl GPR40 modulators |
JP5591706B2 (en) | 2007-10-10 | 2014-09-17 | アムジエン・インコーポレーテツド | Substituted biphenyl GPR40 modulator |
MX2010009654A (en) | 2008-03-06 | 2010-09-28 | Amgen Inc | Conformationally constrained carboxylic acid derivatives useful for treating metabolic disorders. |
AU2009303475B2 (en) | 2008-10-15 | 2012-09-13 | Amgen Inc. | Spirocyclic GPR40 modulators |
-
1977
- 1977-07-01 FR FR7720380A patent/FR2359135A1/en not_active Withdrawn
- 1977-07-08 PT PT66781A patent/PT66781B/en unknown
- 1977-07-09 GR GR53932A patent/GR61995B/en unknown
- 1977-07-15 NL NL7707949A patent/NL7707949A/en not_active Application Discontinuation
- 1977-07-19 AU AU27141/77A patent/AU2714177A/en active Pending
- 1977-07-19 ES ES77460866A patent/ES460866A1/en not_active Expired
- 1977-07-20 DK DK329577A patent/DK329577A/en unknown
- 1977-07-20 SE SE7708368A patent/SE7708368L/en unknown
- 1977-07-21 DE DE19772733305 patent/DE2733305A1/en active Pending
- 1977-07-21 NO NO77772604A patent/NO772604L/en unknown
- 1977-07-22 JP JP8826877A patent/JPS5312851A/en active Pending
Also Published As
Publication number | Publication date |
---|---|
SE7708368L (en) | 1978-01-23 |
DK329577A (en) | 1978-01-23 |
ES460866A1 (en) | 1978-08-16 |
GR61995B (en) | 1979-02-14 |
AU2714177A (en) | 1979-01-25 |
PT66781B (en) | 1978-12-18 |
DE2733305A1 (en) | 1978-01-26 |
PT66781A (en) | 1977-08-01 |
JPS5312851A (en) | 1978-02-04 |
NO772604L (en) | 1978-01-24 |
NL7707949A (en) | 1978-01-24 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RE | Withdrawal of published application |