FR2354100A2 - Medicament a base de 5' thioethers de l'adenosine - Google Patents
Medicament a base de 5' thioethers de l'adenosineInfo
- Publication number
- FR2354100A2 FR2354100A2 FR7717602A FR7717602A FR2354100A2 FR 2354100 A2 FR2354100 A2 FR 2354100A2 FR 7717602 A FR7717602 A FR 7717602A FR 7717602 A FR7717602 A FR 7717602A FR 2354100 A2 FR2354100 A2 FR 2354100A2
- Authority
- FR
- France
- Prior art keywords
- adenosine
- prepd
- alcoholate
- tosyl
- thioether
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002126 C01EB10 - Adenosine Substances 0.000 title abstract 4
- 229960005305 adenosine Drugs 0.000 title abstract 4
- OIRDTQYFTABQOQ-KQYNXXCUSA-N Adenosine Natural products C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O OIRDTQYFTABQOQ-KQYNXXCUSA-N 0.000 title abstract 3
- -1 Adenosine thioether Chemical class 0.000 title abstract 3
- 230000000259 anti-tumor effect Effects 0.000 title 1
- 230000000840 anti-viral effect Effects 0.000 title 1
- 239000003795 chemical substances by application Substances 0.000 title 1
- 125000001475 halogen functional group Chemical group 0.000 title 1
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 abstract 3
- 231100000590 oncogenic Toxicity 0.000 abstract 2
- 230000002246 oncogenic effect Effects 0.000 abstract 2
- IYSNPOMTKFZDHZ-KQYNXXCUSA-N 5'-chloro-5'-deoxyadenosine Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CCl)[C@@H](O)[C@H]1O IYSNPOMTKFZDHZ-KQYNXXCUSA-N 0.000 abstract 1
- 239000004215 Carbon black (E152) Substances 0.000 abstract 1
- 101100054666 Streptomyces halstedii sch3 gene Proteins 0.000 abstract 1
- 241000700605 Viruses Species 0.000 abstract 1
- 230000001621 anti-mitogenic effect Effects 0.000 abstract 1
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 1
- 230000032823 cell division Effects 0.000 abstract 1
- 230000010307 cell transformation Effects 0.000 abstract 1
- 229930195733 hydrocarbon Natural products 0.000 abstract 1
- 150000002430 hydrocarbons Chemical class 0.000 abstract 1
- CBOIHMRHGLHBPB-UHFFFAOYSA-N hydroxymethyl Chemical compound O[CH2] CBOIHMRHGLHBPB-UHFFFAOYSA-N 0.000 abstract 1
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 abstract 1
- 125000000896 monocarboxylic acid group Chemical group 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 125000004055 thiomethyl group Chemical group [H]SC([H])([H])* 0.000 abstract 1
- 230000009466 transformation Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB23702/76A GB1555991A (en) | 1975-06-09 | 1976-06-08 | Pharmaceutical compositions containing adenosine derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2354100A2 true FR2354100A2 (fr) | 1978-01-06 |
| FR2354100B2 FR2354100B2 (enrdf_load_stackoverflow) | 1983-11-25 |
Family
ID=10199904
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR7717602A Granted FR2354100A2 (fr) | 1976-06-08 | 1977-06-08 | Medicament a base de 5' thioethers de l'adenosine |
Country Status (1)
| Country | Link |
|---|---|
| FR (1) | FR2354100A2 (enrdf_load_stackoverflow) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2395990A1 (fr) * | 1977-07-01 | 1979-01-26 | Merrell Toraude & Co | Derives a-acetyleniques d'amines utiles notamment comme inhibiteurs de certaines decarboxylases et leur procede de preparation |
| US4210639A (en) * | 1978-08-29 | 1980-07-01 | The United States Of America As Represented By The Department Of Health, Education And Welfare | 5'-Deoxy-5'-(isobutylthio)-3-deazaadenosine, method of making same and its antiviral effect on Rous sarcoma virus and Gross murine leukemia virus |
| FR2444682A1 (fr) * | 1978-12-19 | 1980-07-18 | Anvar | Derives adenyliques de thioglyceraldehyde-sulfoxide |
| EP0352609A1 (en) * | 1988-07-29 | 1990-01-31 | BIORESEARCH S.p.A. | Use of adenosine derivatives in preparing pharmaceutical compositions possessing immunostimulant activity |
| US4948783A (en) * | 1985-01-24 | 1990-08-14 | Kabushiki Kaisya Advance Kaihatsu Kenkyujo | Anticariogenic or antiperidontitic method |
| EP1003760A4 (en) * | 1997-08-07 | 2002-07-03 | Univ Utah | PROMEDICAMENTS AND CONJUGATES OF THIOL AND SELENOL CONTAINING COMPOUNDS; METHOD OF USING THE SAME |
-
1977
- 1977-06-08 FR FR7717602A patent/FR2354100A2/fr active Granted
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2395990A1 (fr) * | 1977-07-01 | 1979-01-26 | Merrell Toraude & Co | Derives a-acetyleniques d'amines utiles notamment comme inhibiteurs de certaines decarboxylases et leur procede de preparation |
| US4210639A (en) * | 1978-08-29 | 1980-07-01 | The United States Of America As Represented By The Department Of Health, Education And Welfare | 5'-Deoxy-5'-(isobutylthio)-3-deazaadenosine, method of making same and its antiviral effect on Rous sarcoma virus and Gross murine leukemia virus |
| FR2444682A1 (fr) * | 1978-12-19 | 1980-07-18 | Anvar | Derives adenyliques de thioglyceraldehyde-sulfoxide |
| US4948783A (en) * | 1985-01-24 | 1990-08-14 | Kabushiki Kaisya Advance Kaihatsu Kenkyujo | Anticariogenic or antiperidontitic method |
| EP0352609A1 (en) * | 1988-07-29 | 1990-01-31 | BIORESEARCH S.p.A. | Use of adenosine derivatives in preparing pharmaceutical compositions possessing immunostimulant activity |
| EP1003760A4 (en) * | 1997-08-07 | 2002-07-03 | Univ Utah | PROMEDICAMENTS AND CONJUGATES OF THIOL AND SELENOL CONTAINING COMPOUNDS; METHOD OF USING THE SAME |
Also Published As
| Publication number | Publication date |
|---|---|
| FR2354100B2 (enrdf_load_stackoverflow) | 1983-11-25 |
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