FR2353638A1 - Rocking fermenter with internal mixer and external drive - for growing viruses and mammalian cells, e.g. for vaccine prodn. - Google Patents

Rocking fermenter with internal mixer and external drive - for growing viruses and mammalian cells, e.g. for vaccine prodn.

Info

Publication number
FR2353638A1
FR2353638A1 FR7717276A FR7717276A FR2353638A1 FR 2353638 A1 FR2353638 A1 FR 2353638A1 FR 7717276 A FR7717276 A FR 7717276A FR 7717276 A FR7717276 A FR 7717276A FR 2353638 A1 FR2353638 A1 FR 2353638A1
Authority
FR
France
Prior art keywords
prodn
vaccine
rocking
mammalian cells
fermenter
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
FR7717276A
Other languages
French (fr)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Siemens Healthcare Diagnostics GmbH Germany
Original Assignee
Behringwerke AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Behringwerke AG filed Critical Behringwerke AG
Publication of FR2353638A1 publication Critical patent/FR2353638A1/en
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/02—Form or structure of the vessel
    • C12M23/08—Flask, bottle or test tube
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F31/00—Mixers with shaking, oscillating, or vibrating mechanisms
    • B01F31/20—Mixing the contents of independent containers, e.g. test tubes
    • B01F31/23—Mixing the contents of independent containers, e.g. test tubes by pivoting the containers about an axis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F31/00—Mixers with shaking, oscillating, or vibrating mechanisms
    • B01F31/42—Mixers with shaking, oscillating, or vibrating mechanisms with pendulum stirrers, i.e. with stirrers suspended so as to oscillate about fixed points or axes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M27/00—Means for mixing, agitating or circulating fluids in the vessel
    • C12M27/02—Stirrer or mobile mixing elements
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M27/00—Means for mixing, agitating or circulating fluids in the vessel
    • C12M27/16—Vibrating; Shaking; Tilting

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Sustainable Development (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Clinical Laboratory Science (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)

Abstract

A rocking fermenter consists of a cylindrical housing having a flanged cover and a mixing device movably attached to the cover. The housing is rotatably mounted in a frame and attached via lever rods to a drive mechanism. Pref. the mixer, esp. of the cross-bar type, is attached via a flexible pipe to a connecting tube passing through the lid. Used esp. for growing viruses and mammalian cells in suspension cultures. In an example, MKS vines was grown on baby hamster kidney cells for vaccine prodn. The need for a stuffing box is avoided.
FR7717276A 1976-06-04 1977-06-06 Rocking fermenter with internal mixer and external drive - for growing viruses and mammalian cells, e.g. for vaccine prodn. Pending FR2353638A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2625208A DE2625208C3 (en) 1976-06-04 1976-06-04 Fermenter

Publications (1)

Publication Number Publication Date
FR2353638A1 true FR2353638A1 (en) 1977-12-30

Family

ID=5979875

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7717276A Pending FR2353638A1 (en) 1976-06-04 1977-06-06 Rocking fermenter with internal mixer and external drive - for growing viruses and mammalian cells, e.g. for vaccine prodn.

Country Status (4)

Country Link
AR (1) AR210919A1 (en)
DE (1) DE2625208C3 (en)
ES (1) ES454229A1 (en)
FR (1) FR2353638A1 (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0074290A1 (en) * 1981-07-29 1983-03-16 Union Industrielle Et D'entreprise Process and installation for realizing the degradation of organic products, by-products and wastes in an anaerobic medium
EP0409039A1 (en) * 1989-07-19 1991-01-23 Werner Dr. Stahl Bioreactor
EP1896564B1 (en) * 2005-06-29 2020-09-09 Strix Beheer B.V. Method and apparatus for cultivating cells utilizing wave motion

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5346999A (en) * 1985-01-18 1994-09-13 Applied Biosystems, Inc. Method of nucleic acid extraction
CN105664776B (en) * 2016-01-21 2018-07-20 东莞市益友光学科技有限公司 A kind of glue automatic blending system for LED encapsulation

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB191326591A (en) * 1913-11-19 1914-11-12 Henry John Worssam Improvements in Apparatus for Aerating and Agitating Liquid.
FR912115A (en) * 1944-04-21 1946-07-31 Improvements to agitators for mixing liquids
DE1457085A1 (en) * 1964-03-11 1969-10-16 Buerde Dr Hans Process for stirring and mixing with sealless energy supply into the mixing vessel and arrangement for practicing this process
US3875000A (en) * 1974-04-05 1975-04-01 Merck & Co Inc Cell culture apparatus
FR2300130A1 (en) * 1975-02-04 1976-09-03 Commissariat Energie Atomique Agitator for flask contg. suspension of living cells - uses magnetic drive and obviates cell danage by anoxia and abrasion

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB191326591A (en) * 1913-11-19 1914-11-12 Henry John Worssam Improvements in Apparatus for Aerating and Agitating Liquid.
FR912115A (en) * 1944-04-21 1946-07-31 Improvements to agitators for mixing liquids
DE1457085A1 (en) * 1964-03-11 1969-10-16 Buerde Dr Hans Process for stirring and mixing with sealless energy supply into the mixing vessel and arrangement for practicing this process
US3875000A (en) * 1974-04-05 1975-04-01 Merck & Co Inc Cell culture apparatus
FR2300130A1 (en) * 1975-02-04 1976-09-03 Commissariat Energie Atomique Agitator for flask contg. suspension of living cells - uses magnetic drive and obviates cell danage by anoxia and abrasion

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0074290A1 (en) * 1981-07-29 1983-03-16 Union Industrielle Et D'entreprise Process and installation for realizing the degradation of organic products, by-products and wastes in an anaerobic medium
EP0409039A1 (en) * 1989-07-19 1991-01-23 Werner Dr. Stahl Bioreactor
EP1896564B1 (en) * 2005-06-29 2020-09-09 Strix Beheer B.V. Method and apparatus for cultivating cells utilizing wave motion

Also Published As

Publication number Publication date
ES454229A1 (en) 1977-12-01
AR210919A1 (en) 1977-09-30
DE2625208A1 (en) 1977-12-08
DE2625208C3 (en) 1980-02-21
DE2625208B2 (en) 1979-05-31

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