FR2338929A1 - Antiemetic 2-methoxy-benzene sulphonamides - with N-aminoalkyl substituent, also having local anaesthetic, anticonvulsant and antibacterial activity - Google Patents

Antiemetic 2-methoxy-benzene sulphonamides - with N-aminoalkyl substituent, also having local anaesthetic, anticonvulsant and antibacterial activity

Info

Publication number
FR2338929A1
FR2338929A1 FR7601685A FR7601685A FR2338929A1 FR 2338929 A1 FR2338929 A1 FR 2338929A1 FR 7601685 A FR7601685 A FR 7601685A FR 7601685 A FR7601685 A FR 7601685A FR 2338929 A1 FR2338929 A1 FR 2338929A1
Authority
FR
France
Prior art keywords
antiemetic
anticonvulsant
antibacterial activity
methoxy
local anaesthetic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7601685A
Other languages
French (fr)
Other versions
FR2338929B1 (en
Inventor
Robert
Cesar Moreau
Jean-Paul Fournier
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Choay SA
Original Assignee
Choay SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Choay SA filed Critical Choay SA
Priority to FR7601685A priority Critical patent/FR2338929A1/en
Publication of FR2338929A1 publication Critical patent/FR2338929A1/en
Application granted granted Critical
Publication of FR2338929B1 publication Critical patent/FR2338929B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/78—Halides of sulfonic acids
    • C07C309/86—Halides of sulfonic acids having halosulfonyl groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/87—Halides of sulfonic acids having halosulfonyl groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing singly-bound oxygen atoms bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/13—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by hydroxy groups
    • C07C205/26—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by hydroxy groups and being further substituted by halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
    • C07C311/29—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Benzenesulphonamides of formula (I) are new together with their acid-addition salts (where n is 2 or 3; R1 and R2 are H;Me or Et; or R1+R2 and the attached N-atom form a 5- or 6-membered heterocyclic ring, esp. piperidino, pyrrolidino or morpholino; R3 is H, NO2, NH2 or halo; R4 is H, halo or sulphonamido). Cpds. specif. include (I: R3=4-NH2; R4=3-Cl; n=3; R1 and R2 = Me or Et; or n = 2; R1 and R2 = Et). (I) have antiemetic, local anaesthetic and anticonvulsant activity. (I) also have antibacterial activity but low toxicity.
FR7601685A 1976-01-22 1976-01-22 Antiemetic 2-methoxy-benzene sulphonamides - with N-aminoalkyl substituent, also having local anaesthetic, anticonvulsant and antibacterial activity Granted FR2338929A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR7601685A FR2338929A1 (en) 1976-01-22 1976-01-22 Antiemetic 2-methoxy-benzene sulphonamides - with N-aminoalkyl substituent, also having local anaesthetic, anticonvulsant and antibacterial activity

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7601685A FR2338929A1 (en) 1976-01-22 1976-01-22 Antiemetic 2-methoxy-benzene sulphonamides - with N-aminoalkyl substituent, also having local anaesthetic, anticonvulsant and antibacterial activity

Publications (2)

Publication Number Publication Date
FR2338929A1 true FR2338929A1 (en) 1977-08-19
FR2338929B1 FR2338929B1 (en) 1980-05-16

Family

ID=9168232

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7601685A Granted FR2338929A1 (en) 1976-01-22 1976-01-22 Antiemetic 2-methoxy-benzene sulphonamides - with N-aminoalkyl substituent, also having local anaesthetic, anticonvulsant and antibacterial activity

Country Status (1)

Country Link
FR (1) FR2338929A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0064006A1 (en) * 1981-04-23 1982-11-03 Choay S.A. Substituted 2,4-dialkoxybenzenesulfonyl chlorides

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0064006A1 (en) * 1981-04-23 1982-11-03 Choay S.A. Substituted 2,4-dialkoxybenzenesulfonyl chlorides

Also Published As

Publication number Publication date
FR2338929B1 (en) 1980-05-16

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Legal Events

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