FR2338268A1 - (5)-Aryloxymethyl-oxazolidin-(2)-ones - used in prepn. of aryloxypropanolamine beta:blockers - Google Patents

(5)-Aryloxymethyl-oxazolidin-(2)-ones - used in prepn. of aryloxypropanolamine beta:blockers

Info

Publication number
FR2338268A1
FR2338268A1 FR7601044A FR7601044A FR2338268A1 FR 2338268 A1 FR2338268 A1 FR 2338268A1 FR 7601044 A FR7601044 A FR 7601044A FR 7601044 A FR7601044 A FR 7601044A FR 2338268 A1 FR2338268 A1 FR 2338268A1
Authority
FR
France
Prior art keywords
prepn
oxazolidin
beta
opt
blockers
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7601044A
Other languages
French (fr)
Other versions
FR2338268B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
NATIVELLE SpA
Original Assignee
NATIVELLE SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by NATIVELLE SpA filed Critical NATIVELLE SpA
Priority to FR7601044A priority Critical patent/FR2338268A1/en
Publication of FR2338268A1 publication Critical patent/FR2338268A1/en
Application granted granted Critical
Publication of FR2338268B1 publication Critical patent/FR2338268B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • C07D263/24—Oxygen atoms attached in position 2 with hydrocarbon radicals, substituted by oxygen atoms, attached to other ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

Oxazolidinone derivs. of formula (I) are new: (where Ar is opt. substd. aryl or heterocyclic; R is cycloalkyl or opt. branched alkyl). They are prepd. by reacting a 3-aryloxy-1,2-epoxypropane Ar-O-CH2-CH-CH2 (II) with a carbamate R1O-CO-NHR in presence of an alkali metal hydride. (where R1 is opt. branched alkyl, aryl or aralkyl). (I) are used in prepn. of aryloxypropanolamines (IV) useful as beta-adrenergic receptor blockers. (IV) can be obtd. simply and in good yield (ca 90%) in a 1-step process from (I) in alkaline medium. A claimed (I) is 5-(1-naphtyloxymethyl)-3-isopropyl-oxazolidin-2-one.
FR7601044A 1976-01-16 1976-01-16 (5)-Aryloxymethyl-oxazolidin-(2)-ones - used in prepn. of aryloxypropanolamine beta:blockers Granted FR2338268A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR7601044A FR2338268A1 (en) 1976-01-16 1976-01-16 (5)-Aryloxymethyl-oxazolidin-(2)-ones - used in prepn. of aryloxypropanolamine beta:blockers

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7601044A FR2338268A1 (en) 1976-01-16 1976-01-16 (5)-Aryloxymethyl-oxazolidin-(2)-ones - used in prepn. of aryloxypropanolamine beta:blockers

Publications (2)

Publication Number Publication Date
FR2338268A1 true FR2338268A1 (en) 1977-08-12
FR2338268B1 FR2338268B1 (en) 1980-06-20

Family

ID=9167992

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7601044A Granted FR2338268A1 (en) 1976-01-16 1976-01-16 (5)-Aryloxymethyl-oxazolidin-(2)-ones - used in prepn. of aryloxypropanolamine beta:blockers

Country Status (1)

Country Link
FR (1) FR2338268A1 (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2404001A1 (en) * 1977-09-22 1979-04-20 Menarini Sas OXAZOLIDONE-2 DERIVATIVES USEFUL AS MEDICINAL PRODUCTS AND METHODS FOR THEIR PREPARATION
EP0086403A2 (en) * 1982-02-16 1983-08-24 MERCK PATENT GmbH 2-Oxazolidine-ones
FR2545488A1 (en) * 1983-05-02 1984-11-09 Delalande Sa New cyclic carbamates having a side chain of the arylmethyl or aryloxymethyl type, processes for their preparation and therapeutic application
US7081538B1 (en) 1999-12-03 2006-07-25 Astrazeneca Ab Substituted isoxazolines and their use as antibacterial agents
US7141583B2 (en) 2000-04-25 2006-11-28 Astrazeneca Ab Oxazolidinone derivatives with antibiotic activity

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2404001A1 (en) * 1977-09-22 1979-04-20 Menarini Sas OXAZOLIDONE-2 DERIVATIVES USEFUL AS MEDICINAL PRODUCTS AND METHODS FOR THEIR PREPARATION
EP0086403A2 (en) * 1982-02-16 1983-08-24 MERCK PATENT GmbH 2-Oxazolidine-ones
EP0086403A3 (en) * 1982-02-16 1984-10-10 MERCK PATENT GmbH 2-oxazolidine-ones
FR2545488A1 (en) * 1983-05-02 1984-11-09 Delalande Sa New cyclic carbamates having a side chain of the arylmethyl or aryloxymethyl type, processes for their preparation and therapeutic application
US7081538B1 (en) 1999-12-03 2006-07-25 Astrazeneca Ab Substituted isoxazolines and their use as antibacterial agents
US7141583B2 (en) 2000-04-25 2006-11-28 Astrazeneca Ab Oxazolidinone derivatives with antibiotic activity

Also Published As

Publication number Publication date
FR2338268B1 (en) 1980-06-20

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