FR2326192A1 - NEW PYRIMIDONES, THEIR PREPARATION PROCESS AND THEIR THERAPEUTIC APPLICATION - Google Patents
NEW PYRIMIDONES, THEIR PREPARATION PROCESS AND THEIR THERAPEUTIC APPLICATIONInfo
- Publication number
- FR2326192A1 FR2326192A1 FR7628824A FR7628824A FR2326192A1 FR 2326192 A1 FR2326192 A1 FR 2326192A1 FR 7628824 A FR7628824 A FR 7628824A FR 7628824 A FR7628824 A FR 7628824A FR 2326192 A1 FR2326192 A1 FR 2326192A1
- Authority
- FR
- France
- Prior art keywords
- pyrimidones
- new
- preparation process
- formula
- therapeutic application
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000002360 preparation method Methods 0.000 title 1
- 150000008318 pyrimidones Chemical class 0.000 title 1
- 230000001225 therapeutic effect Effects 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 239000005864 Sulphur Substances 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 239000000938 histamine H1 antagonist Substances 0.000 abstract 1
- 239000003485 histamine H2 receptor antagonist Substances 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- CYQAYERJWZKYML-UHFFFAOYSA-N phosphorus pentasulfide Chemical compound S1P(S2)(=S)SP3(=S)SP1(=S)SP2(=S)S3 CYQAYERJWZKYML-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/60—Three or more oxygen or sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/56—One oxygen atom and one sulfur atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Compounds of the formula I in which the symbols have the meanings stated in Claims 1 and 5 are histamine H2 antagonists with improved activity and, moreover, histamine H1 antagonists. They are prepared by reacting compounds of the formula II with those of the formula III. Reaction of the resulting compounds of the formula I with phosphorus pentasulphide results in replacement of the oxygen at the position of X by sulphur.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB4034175 | 1975-10-02 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2326192A1 true FR2326192A1 (en) | 1977-04-29 |
| FR2326192B1 FR2326192B1 (en) | 1979-01-12 |
Family
ID=10414412
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR7628824A Granted FR2326192A1 (en) | 1975-10-02 | 1976-09-24 | NEW PYRIMIDONES, THEIR PREPARATION PROCESS AND THEIR THERAPEUTIC APPLICATION |
Country Status (36)
| Country | Link |
|---|---|
| JP (2) | JPS5246087A (en) |
| AR (1) | AR221682A1 (en) |
| AT (1) | AT358045B (en) |
| AU (1) | AU504897B2 (en) |
| BE (1) | BE846452A (en) |
| BG (1) | BG25224A3 (en) |
| CA (1) | CA1067076A (en) |
| CH (1) | CH625801A5 (en) |
| CS (1) | CS203003B2 (en) |
| DD (1) | DD126563A5 (en) |
| DE (1) | DE2643670C2 (en) |
| DK (1) | DK442476A (en) |
| ES (1) | ES452060A1 (en) |
| FI (1) | FI61701C (en) |
| FR (1) | FR2326192A1 (en) |
| GR (1) | GR61307B (en) |
| HU (1) | HU175537B (en) |
| IE (1) | IE44845B1 (en) |
| IL (1) | IL50503A (en) |
| IN (1) | IN146736B (en) |
| IT (2) | IT1070839B (en) |
| LU (1) | LU75922A1 (en) |
| MW (1) | MW3476A1 (en) |
| MX (1) | MX4614E (en) |
| NL (1) | NL7609917A (en) |
| NO (1) | NO145792C (en) |
| NZ (1) | NZ181959A (en) |
| OA (1) | OA05445A (en) |
| PH (1) | PH13921A (en) |
| PL (1) | PL105828B1 (en) |
| PT (1) | PT65590B (en) |
| RO (1) | RO73511A (en) |
| SE (1) | SE431872B (en) |
| YU (1) | YU237276A (en) |
| ZA (1) | ZA765498B (en) |
| ZM (1) | ZM12176A1 (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0003677A2 (en) * | 1978-02-13 | 1979-08-22 | Smith Kline & French Laboratories Limited | Pyrimidones, processes for their preparation and pharmaceutical compositions containing them |
| WO1980000966A1 (en) * | 1978-11-13 | 1980-05-15 | Smith Kline French Lab | New histamine h2-antagonists |
| EP0039989B1 (en) * | 1980-03-29 | 1984-08-29 | Smith Kline & French Laboratories Limited | Pyrimidone derivatives, processes for their preparation and pharmaceutical compositions containing them |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MW5076A1 (en) * | 1975-12-29 | 1978-02-08 | Smith Kline French Lab | Pharmacologicalle active compounds |
| NZ186511A (en) | 1977-03-19 | 1980-11-14 | Smith Kline French Lab | 3-substituted alkylamino-6-substituted alkyl-1,2,4-triazin-5-ones and pharmaceutical compositions 3-substituted thio-1,2,4-triazin-5-ones |
| ZA782129B (en) | 1977-04-20 | 1979-03-28 | Ici Ltd | Hertocyclic derivatives |
| US4165378A (en) | 1977-04-20 | 1979-08-21 | Ici Americas Inc. | Guanidine derivatives of imidazoles and thiazoles |
| JPS54104816A (en) * | 1978-01-27 | 1979-08-17 | Memorex Corp | Magnetic recorder tape reel |
| PH16240A (en) * | 1978-04-11 | 1983-08-11 | Smith Kline French Lab | Process for making histamine antagonist |
| ZA792608B (en) * | 1978-05-30 | 1980-06-25 | Smith Kline French Lab | Nitro compounds |
| ZA793443B (en) * | 1978-07-26 | 1980-12-31 | Glaxo Group Ltd | Heterocyclic derivatives |
| US4374836A (en) | 1978-10-16 | 1983-02-22 | Imperial Chemical Industries Ltd. | Antisecretory heterocyclic derivatives, process for their manufacture and pharmaceutical compositions containing them |
| US4521418A (en) * | 1979-02-21 | 1985-06-04 | Smith Kline & French Laboratories Limited | Guanidinothiazolyl derivatives |
| JPS55145683A (en) * | 1979-04-26 | 1980-11-13 | Smith Kline French Lab | Pyrimidone derivative |
| ZW21281A1 (en) * | 1980-10-01 | 1981-11-18 | Smith Kline French Lab | Amine derivatives |
| IE53068B1 (en) * | 1981-06-15 | 1988-05-25 | Merck & Co Inc | Diamino isothiazole-1-oxides and -1,1-dioxides as gastic secretion inhibitors |
| PT75074B (en) * | 1981-06-27 | 1986-02-26 | Smith Kline French Lab | Process for preparing certain pyrimidone derivatives and compositions containing them |
| NZ202797A (en) * | 1981-12-28 | 1985-08-30 | Lilly Co Eli | Pyrimidine derivatives and pharmaceutical compositions |
| JPS5993074A (en) * | 1982-10-01 | 1984-05-29 | スミス・クライン・アンド・フレンチ・ラボラトリ−ス・リミテツド | Pyrimidone derivative |
| DE8309239U1 (en) * | 1983-03-29 | 1983-09-29 | Basf Ag, 6700 Ludwigshafen | TAPE REEL, IN PARTICULAR FOR MAGNETIC TAPES |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1397436A (en) * | 1972-09-05 | 1975-06-11 | Smith Kline French Lab | Heterocyclic n-cyanoguinidines |
| GB1419994A (en) * | 1973-05-03 | 1976-01-07 | Smith Kline French Lab | Heterocyclicalkylaminotheterocyclic compounds methods for their preparation and compositions comprising them |
-
1976
- 1976-09-06 IN IN1633/CAL/76A patent/IN146736B/en unknown
- 1976-09-07 NL NL7609917A patent/NL7609917A/en unknown
- 1976-09-07 NZ NZ181959A patent/NZ181959A/en unknown
- 1976-09-10 MW MW34/76A patent/MW3476A1/en unknown
- 1976-09-14 ZA ZA765498A patent/ZA765498B/en unknown
- 1976-09-14 IT IT27192/76A patent/IT1070839B/en active
- 1976-09-14 PT PT65590A patent/PT65590B/en unknown
- 1976-09-16 IL IL50503A patent/IL50503A/en unknown
- 1976-09-20 SE SE7610409A patent/SE431872B/en not_active IP Right Cessation
- 1976-09-22 BE BE170830A patent/BE846452A/en not_active IP Right Cessation
- 1976-09-24 FR FR7628824A patent/FR2326192A1/en active Granted
- 1976-09-24 PH PH18943A patent/PH13921A/en unknown
- 1976-09-24 AT AT711976A patent/AT358045B/en not_active IP Right Cessation
- 1976-09-27 CS CS766222A patent/CS203003B2/en unknown
- 1976-09-28 YU YU02372/76A patent/YU237276A/en unknown
- 1976-09-28 DE DE2643670A patent/DE2643670C2/en not_active Expired
- 1976-09-28 GR GR51794A patent/GR61307B/en unknown
- 1976-09-28 CA CA262,162A patent/CA1067076A/en not_active Expired
- 1976-09-29 IE IE2154/76A patent/IE44845B1/en unknown
- 1976-09-29 OA OA55946A patent/OA05445A/en unknown
- 1976-09-30 AU AU18295/76A patent/AU504897B2/en not_active Expired
- 1976-09-30 DD DD195067A patent/DD126563A5/xx unknown
- 1976-09-30 AR AR264926A patent/AR221682A1/en active
- 1976-10-01 BG BG7600034338A patent/BG25224A3/en unknown
- 1976-10-01 FI FI762803A patent/FI61701C/en not_active IP Right Cessation
- 1976-10-01 CH CH1248276A patent/CH625801A5/en not_active IP Right Cessation
- 1976-10-01 ZM ZM121/76A patent/ZM12176A1/en unknown
- 1976-10-01 NO NO763371A patent/NO145792C/en unknown
- 1976-10-01 DK DK442476A patent/DK442476A/en not_active Application Discontinuation
- 1976-10-01 MX MX764951U patent/MX4614E/en unknown
- 1976-10-01 JP JP51118904A patent/JPS5246087A/en active Granted
- 1976-10-01 LU LU75922A patent/LU75922A1/xx unknown
- 1976-10-01 HU HU76SI1543A patent/HU175537B/en unknown
- 1976-10-01 PL PL1976192809A patent/PL105828B1/en unknown
- 1976-10-01 ES ES452060A patent/ES452060A1/en not_active Expired
- 1976-10-02 RO RO7687887A patent/RO73511A/en unknown
-
1978
- 1978-12-11 IT IT7830708A patent/IT7830708A0/en unknown
-
1980
- 1980-12-09 JP JP55174447A patent/JPS609755B2/en not_active Expired
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0003677A2 (en) * | 1978-02-13 | 1979-08-22 | Smith Kline & French Laboratories Limited | Pyrimidones, processes for their preparation and pharmaceutical compositions containing them |
| EP0003677A3 (en) * | 1978-02-13 | 1979-09-05 | Smith Kline & French Laboratories Limited | Pyrimidones, processes for their preparation and pharmaceutical compositions containing them |
| WO1980000966A1 (en) * | 1978-11-13 | 1980-05-15 | Smith Kline French Lab | New histamine h2-antagonists |
| EP0013071A1 (en) * | 1978-11-13 | 1980-07-09 | Smith Kline & French Laboratories Limited | Pyrimidinone derivatives, processes for preparing them and pharmaceutical compositions containing them |
| EP0039989B1 (en) * | 1980-03-29 | 1984-08-29 | Smith Kline & French Laboratories Limited | Pyrimidone derivatives, processes for their preparation and pharmaceutical compositions containing them |
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| FR2326192A1 (en) | NEW PYRIMIDONES, THEIR PREPARATION PROCESS AND THEIR THERAPEUTIC APPLICATION | |
| FR2336935A1 (en) | NEW PYRIMIDONS, THEIR PREPARATION PROCESS AND THEIR APPLICATION | |
| ES2040208T3 (en) | INSECTICIDED PIRAZOLINS. | |
| FR2406629A1 (en) | 5-TRIFLUOROMETHYLPYRIDINES SUBSTITUTED IN POSITION 2 AND THEIR PREPARATION PROCESS | |
| FR2366297A1 (en) | NEW CEPHALOSPORINS, THEIR PROCESS OF PREPARATION AND THEIR APPLICATION IN THERAPEUTICS | |
| ES449083A1 (en) | Halo-substituted 1-loweralkyl-5-aroylpyrrole-2-acetic acid compounds | |
| OA05386A (en) | New N- (3-trifluoromethyl-4-halo-phenyl) -N'-benzolyl-ureas, their preparation process and their application as insecticides. | |
| BE848911A (en) | NEW BIS-CARBAMOYL N-ASYMETRIC SUBSTITUTES SULPHIDES, THEIR PREPARATION PROCESS AND THEIR APPLICATION AS INSECTICIDES AND ACARICIDES | |
| FR2322140A1 (en) | NEW 3-ALKOXY-BENZO-1,2,4-TRIAZINES, THEIR PREPARATION PROCESS AND THEIR APPLICATION AS FUNGICIDES AND BACTERICIDES | |
| BE848913A (en) | NEW ASYMETRIC BIS-CARBAMOYL-N-SUBSTITUTE SULPHIDES, THEIR PREPARATION PROCESS AND THEIR APPLICATION AS INSECTICIDES AND ACARICIDES | |
| BE858024A (en) | NEW SUBSTITUTED BENZYLUREES, THEIR PREPARATION PROCESS AND THEIR APPLICATION AS INSECTICIDES | |
| FR2421900A1 (en) | PIPERAZINO-3-INDOLES, THEIR PREPARATION PROCESS AND THEIR THERAPEUTIC APPLICATIONS | |
| FR2335522A1 (en) | PROCESS FOR THE PREPARATION OF ANDROSTENE-4 DIONES-3,17 | |
| ES485733A1 (en) | 1-Acyloxyphenyl-1,2-diphenylalkene derivatives, processes for their manufacture and a pharmaceutical composition containing these derivatives. | |
| FR2314192A1 (en) | PROCESS FOR PREPARATION OF OXAPHOSPHOLANES-1,2 | |
| FR2361881A2 (en) | NEW SULFOXIDES, THEIR PREPARATION PROCESS AND THEIR APPLICATION | |
| LU78874A1 (en) | PROCESS FOR THE PREPARATION OF NEW SULFONYLHYDRAZONES OF 1,4-DIOXO-AND 4-OXOQUINOXALINE-2-CARBOXALDEHYDE | |
| BE845327A (en) | PROCESS FOR THE PREPARATION OF 4,4'-DIHYDROXY-3-3'-5-5'-TRETRALCOYLDIPHENYLALCANES | |
| FR2368489A1 (en) | CLAVULIN DERIVATIVES, THEIR PREPARATION PROCESS AND THEIR THERAPEUTIC APPLICATION | |
| FR2416228A1 (en) | 4-PYRIMIDYL SULPHIDES, THEIR PREPARATION PROCESS AND THEIR THERAPEUTIC APPLICATION | |
| FR2297917A1 (en) | DESULFURATION OF FUSION STEELS | |
| FR2326422A1 (en) | PROCESS FOR THE PRODUCTION OF NEW TRIAZINE-2,4-DIONES AND THEIR APPLICATION AS INSECTICIDES | |
| BE848118A (en) | PROCESS FOR THE PRODUCTION OF AN EXTINGUISHING COMPOUND, | |
| BE838832A (en) | PROSTANOIC ACID ANALOGUES, THEIR PREPARATION PROCESS AND THEIR APPLICATIONS | |
| FR2398070A1 (en) | NEWS 1-PIPERAZINYL-TRIAZOLO-THIENO-1,4-DIAZEPINES SUBSTITUTES AND THEIR APPLICATION AS MEDICINAL PRODUCTS |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ST | Notification of lapse |