FR2316966A1 - Antifungal antibiotic S 31794/F-1 - produced by cultivation of the fungus Acrophialophora limonispora(BE060177) - Google Patents
Antifungal antibiotic S 31794/F-1 - produced by cultivation of the fungus Acrophialophora limonispora(BE060177)Info
- Publication number
- FR2316966A1 FR2316966A1 FR7620770A FR7620770A FR2316966A1 FR 2316966 A1 FR2316966 A1 FR 2316966A1 FR 7620770 A FR7620770 A FR 7620770A FR 7620770 A FR7620770 A FR 7620770A FR 2316966 A1 FR2316966 A1 FR 2316966A1
- Authority
- FR
- France
- Prior art keywords
- activity
- limonispora
- fungus
- cultivation
- produced
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 241000572100 Acrophialophora Species 0.000 title abstract 2
- QZRPBFSNQQUAAB-QZXUYJGCSA-N acrophiarin Chemical compound CCCCCCCCCCCCCC(=O)N[C@H]1C[C@H]([C@H](NC(=O)[C@@H]2[C@H]([C@H](CN2C(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H]3C[C@H](CN3C(=O)[C@@H](NC1=O)[C@@H](C)O)O)[C@@H]([C@H](C4=CC=C(C=C4)O)O)O)[C@@H](CC(=O)N)O)C)O)O)O QZRPBFSNQQUAAB-QZXUYJGCSA-N 0.000 title abstract 2
- 230000000843 anti-fungal effect Effects 0.000 title 1
- 229940121375 antifungal agent Drugs 0.000 title 1
- 230000000694 effects Effects 0.000 abstract 4
- 241000222122 Candida albicans Species 0.000 abstract 2
- 235000010633 broth Nutrition 0.000 abstract 2
- 229940095731 candida albicans Drugs 0.000 abstract 2
- 238000000855 fermentation Methods 0.000 abstract 2
- 230000004151 fermentation Effects 0.000 abstract 2
- 241000894006 Bacteria Species 0.000 abstract 1
- 241000222120 Candida <Saccharomycetales> Species 0.000 abstract 1
- 241000233866 Fungi Species 0.000 abstract 1
- GXCLVBGFBYZDAG-UHFFFAOYSA-N N-[2-(1H-indol-3-yl)ethyl]-N-methylprop-2-en-1-amine Chemical compound CN(CCC1=CNC2=C1C=CC=C2)CC=C GXCLVBGFBYZDAG-UHFFFAOYSA-N 0.000 abstract 1
- 241000221961 Neurospora crassa Species 0.000 abstract 1
- 241000235645 Pichia kudriavzevii Species 0.000 abstract 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 abstract 1
- 206010040047 Sepsis Diseases 0.000 abstract 1
- 241001085826 Sporotrichum Species 0.000 abstract 1
- 241001045770 Trichophyton mentagrophytes Species 0.000 abstract 1
- 230000000845 anti-microbial effect Effects 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 238000011534 incubation Methods 0.000 abstract 1
- 235000015097 nutrients Nutrition 0.000 abstract 1
- 230000001717 pathogenic effect Effects 0.000 abstract 1
- 238000013207 serial dilution Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/50—Cyclic peptides containing at least one abnormal peptide link
- C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
- C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Antibiotic S 31794/F-1 (I) is a new cpd. produced by (a) cultivating a (I)-producing strain of the fungus Acrophialophora limonispora nov. spec. Dreyfuss et Muller on or in a nutrient medium and (b) isolating (I) from the fermentation broth and purifying inconventional manner. Fermentation broths obtained in the cultivation of (I)-producing strains of A. limonispora are also novel products. (I) has antimicrobial activity, particularly against yeasts and fungi. It has no activity against usual Gram-positive and Gram-negative bacteria. The activity of (I) against Candida strains pathogenic to humans if particularly marked. This, in serial dilution tests using 2% malt extact, pH 5.2-5.4. with incubation for 48-72 hrs. at 27 degrees, (I) has MIC's of 0.3, 1,32, 100 and 100 against Candida albicans, Candida Krusei, Trichophyton mentagrophytes, Sporotrichum schenkii and Neurospora crassa, respectively. (I) shows activity in vivo tests for activity against Candida albicans sepsis.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH889475 | 1975-07-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| FR2316966A1 true FR2316966A1 (en) | 1977-02-04 |
Family
ID=4345963
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR7620770A Withdrawn FR2316966A1 (en) | 1975-07-08 | 1976-07-07 | Antifungal antibiotic S 31794/F-1 - produced by cultivation of the fungus Acrophialophora limonispora(BE060177) |
Country Status (16)
| Country | Link |
|---|---|
| JP (1) | JPS5210493A (en) |
| AT (1) | ATA492476A (en) |
| AU (1) | AU1564776A (en) |
| BE (1) | BE843845A (en) |
| DE (1) | DE2628965A1 (en) |
| DK (1) | DK292776A (en) |
| ES (1) | ES449582A1 (en) |
| FI (1) | FI761878A (en) |
| FR (1) | FR2316966A1 (en) |
| IL (1) | IL49978A0 (en) |
| NL (1) | NL7607326A (en) |
| NO (1) | NO762267L (en) |
| NZ (1) | NZ181395A (en) |
| PT (1) | PT65328B (en) |
| SE (1) | SE7607472L (en) |
| ZA (1) | ZA764071B (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5452797A (en) * | 1977-10-04 | 1979-04-25 | Meiji Seika Kaisha Ltd | Novel antibiotic substance bn-200, and its preparation |
| CA1170598A (en) * | 1979-12-13 | 1984-07-10 | Bernard J. Abbott | Process for the preparation of cyclic peptide nuclei |
| JPH01227817A (en) * | 1988-03-09 | 1989-09-12 | Kioritz Corp | Two cycle uniflow spark ignition engine |
-
1976
- 1976-06-06 ES ES449582A patent/ES449582A1/en not_active Expired
- 1976-06-28 DE DE19762628965 patent/DE2628965A1/en active Pending
- 1976-06-29 DK DK292776A patent/DK292776A/en unknown
- 1976-06-29 FI FI761878A patent/FI761878A/fi not_active Application Discontinuation
- 1976-06-30 SE SE7607472A patent/SE7607472L/en unknown
- 1976-06-30 NO NO762267A patent/NO762267L/no unknown
- 1976-07-02 NL NL7607326A patent/NL7607326A/en not_active Application Discontinuation
- 1976-07-06 AT AT492476A patent/ATA492476A/en not_active Application Discontinuation
- 1976-07-06 AU AU15647/76A patent/AU1564776A/en not_active Expired
- 1976-07-06 BE BE168687A patent/BE843845A/en unknown
- 1976-07-06 IL IL49978A patent/IL49978A0/en unknown
- 1976-07-06 NZ NZ181395A patent/NZ181395A/en unknown
- 1976-07-07 JP JP51079984A patent/JPS5210493A/en active Pending
- 1976-07-07 PT PT65328A patent/PT65328B/en unknown
- 1976-07-07 FR FR7620770A patent/FR2316966A1/en not_active Withdrawn
- 1976-07-08 ZA ZA00764071A patent/ZA764071B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE2628965A1 (en) | 1977-01-20 |
| NO762267L (en) | 1977-01-11 |
| FI761878A (en) | 1977-01-09 |
| PT65328A (en) | 1976-08-01 |
| PT65328B (en) | 1978-04-05 |
| NZ181395A (en) | 1978-09-25 |
| DK292776A (en) | 1977-01-09 |
| AU1564776A (en) | 1978-01-12 |
| ZA764071B (en) | 1978-02-22 |
| SE7607472L (en) | 1977-01-09 |
| JPS5210493A (en) | 1977-01-26 |
| IL49978A0 (en) | 1976-09-30 |
| ES449582A1 (en) | 1977-12-01 |
| BE843845A (en) | 1977-01-06 |
| ATA492476A (en) | 1979-05-15 |
| NL7607326A (en) | 1977-01-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ST | Notification of lapse |