FR2316234B1 - - Google Patents

Info

Publication number
FR2316234B1
FR2316234B1 FR7620102A FR7620102A FR2316234B1 FR 2316234 B1 FR2316234 B1 FR 2316234B1 FR 7620102 A FR7620102 A FR 7620102A FR 7620102 A FR7620102 A FR 7620102A FR 2316234 B1 FR2316234 B1 FR 2316234B1
Authority
FR
France
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
FR7620102A
Other languages
French (fr)
Other versions
FR2316234A1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Leo AB
Original Assignee
Leo AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Leo AB filed Critical Leo AB
Publication of FR2316234A1 publication Critical patent/FR2316234A1/fr
Application granted granted Critical
Publication of FR2316234B1 publication Critical patent/FR2316234B1/fr
Granted legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D223/00Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/18Dibenzazepines; Hydrogenated dibenzazepines
    • C07D223/22Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines
    • C07D223/24Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom
    • C07D223/28Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom having a single bond between positions 10 and 11

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
FR7620102A 1975-07-03 1976-07-01 Procede pour la preparation de chlorhydrate de 4'-chloro-2-((3-(10,11-dihydro-5h-dibenz (b, f) azepinyl-(5))-propyl)-methylamino)-acetophenone (ou chlorhydrate de lofepramine) Granted FR2316234A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB28145/75A GB1497306A (en) 1975-07-03 1975-07-03 Preparation of lofepramine and its hydrochloride

Publications (2)

Publication Number Publication Date
FR2316234A1 FR2316234A1 (fr) 1977-01-28
FR2316234B1 true FR2316234B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1979-06-08

Family

ID=10270996

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7620102A Granted FR2316234A1 (fr) 1975-07-03 1976-07-01 Procede pour la preparation de chlorhydrate de 4'-chloro-2-((3-(10,11-dihydro-5h-dibenz (b, f) azepinyl-(5))-propyl)-methylamino)-acetophenone (ou chlorhydrate de lofepramine)

Country Status (10)

Country Link
US (1) US4172074A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JP (1) JPS6014030B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
BE (1) BE843691A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CA (1) CA1079274A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CH (1) CH618686A5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DE (1) DE2628558A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
FR (1) FR2316234A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
GB (1) GB1497306A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IE (1) IE43255B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
SE (1) SE7607565L (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4108119A1 (de) * 1991-03-13 1992-09-17 Jellalabad Ltd Verfahren zur herstellung von 4'-chlor-2-((3-(10,11-dihydro-5h-dibenz(b,f)azepin-5-yl)propyl) methylaminno) acetophenon und seiner salze, die stabilisierungseiner salze, hierbei erhaeltliche produkte und pharmmazeutische zubereitungen, die diese enthalten
GB2308065B (en) * 1994-10-05 1999-01-13 Cari Loder Treatment of multiple sclerosis (MS) and other demyelinating conditions
EP0784476B1 (en) 1994-10-05 2002-11-06 Cari Loder Treatment of multiple sclerosis (ms) and other demyelinating conditions using lofepramine in combination with l-phenylalanine, tyrosine or tryptophan and optionally a vitamin b 12 compound
JP5646126B2 (ja) 2003-12-11 2014-12-24 サノビオン ファーマシューティカルズ インクSunovion Pharmaceuticals Inc. 鎮静剤と神経伝達物質調節剤の併用、および睡眠の質の向上方法および鬱の治療方法
WO2006038084A1 (en) * 2004-10-01 2006-04-13 Neurocure Ltd Use of pharmaceutical compositions of lofepramine for the treatment of adhd, cfs, fm and depression
AU2006269231A1 (en) * 2005-07-08 2007-01-18 Braincells, Inc. Methods for identifying agents and conditions that modulate neurogenesis
US20070112017A1 (en) 2005-10-31 2007-05-17 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
AU2007249435A1 (en) 2006-05-09 2007-11-22 Braincells, Inc. 5 HT receptor mediated neurogenesis
EP2377531A2 (en) 2006-05-09 2011-10-19 Braincells, Inc. Neurogenesis by modulating angiotensin
US7858611B2 (en) * 2006-05-09 2010-12-28 Braincells Inc. Neurogenesis by modulating angiotensin
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
WO2008083204A2 (en) * 2006-12-28 2008-07-10 Braincells, Inc. Modulation of neurogenesis by melatoninergic ligands
US20080171750A1 (en) * 2007-01-11 2008-07-17 Braincells, Inc. Modulation Of Neurogenesis With Use of Modafinil
WO2009128058A1 (en) 2008-04-18 2009-10-22 UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN et al Psycho-pharmaceuticals

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1177525A (en) * 1967-04-13 1970-01-14 Leo Ab New Heterocyclic Aminoketones of Therapeutic Interest

Also Published As

Publication number Publication date
CA1079274A (en) 1980-06-10
FR2316234A1 (fr) 1977-01-28
DE2628558C2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1989-11-16
JPS527982A (en) 1977-01-21
IE43255B1 (en) 1981-01-14
US4172074A (en) 1979-10-23
CH618686A5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1980-08-15
SE7607565L (sv) 1977-01-04
JPS6014030B2 (ja) 1985-04-11
BE843691A (fr) 1977-01-03
DE2628558A1 (de) 1977-01-20
GB1497306A (en) 1978-01-05
IE43255L (en) 1977-01-03

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