FR2312245A1 - Apovincaminic and desoxyvincaminic acid amides - of cycloalkyl amines for treatment of anoxic disorders - Google Patents

Apovincaminic and desoxyvincaminic acid amides - of cycloalkyl amines for treatment of anoxic disorders

Info

Publication number
FR2312245A1
FR2312245A1 FR7516290A FR7516290A FR2312245A1 FR 2312245 A1 FR2312245 A1 FR 2312245A1 FR 7516290 A FR7516290 A FR 7516290A FR 7516290 A FR7516290 A FR 7516290A FR 2312245 A1 FR2312245 A1 FR 2312245A1
Authority
FR
France
Prior art keywords
desoxyvincaminic
apovincaminic
treatment
acid amides
disorders
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7516290A
Other languages
French (fr)
Other versions
FR2312245B1 (en
Inventor
Don Pierre Rene Luc Giudicelli
Henry Najer
Patrick Andre Louis Lardenois
Jean Pierre Gaston Lefevre
Bogdan Iliesco-Branceni
Icilio Angelo Girolamo Cavero
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Synthelabo SA
Original Assignee
Synthelabo SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FI751840*A priority Critical patent/FI751840A/fi
Application filed by Synthelabo SA filed Critical Synthelabo SA
Priority to FR7516290A priority patent/FR2312245A1/en
Priority to SE7507088A priority patent/SE7507088L/en
Priority to NO752192A priority patent/NO752192L/no
Priority to DK277975AA priority patent/DK138427B/en
Priority to ES75438799A priority patent/ES438799A1/en
Priority to IE1391/75A priority patent/IE41260B1/en
Priority to US05/589,088 priority patent/US4011330A/en
Priority to CH818075A priority patent/CH603651A5/xx
Priority to LU72792A priority patent/LU72792A1/xx
Priority to DE2528609A priority patent/DE2528609C3/en
Priority to DE2559558A priority patent/DE2559558C3/en
Priority to CA230,244A priority patent/CA1031344A/en
Priority to GB2736975A priority patent/GB1460235A/en
Priority to JP50079923A priority patent/JPS5139699A/en
Priority to IL47590A priority patent/IL47590A/en
Priority to AU82571/75A priority patent/AU491040B2/en
Priority to NL7508740A priority patent/NL7508740A/en
Priority to JP656176A priority patent/JPS51141898A/en
Publication of FR2312245A1 publication Critical patent/FR2312245A1/en
Application granted granted Critical
Publication of FR2312245B1 publication Critical patent/FR2312245B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Apovincaminic and desoxyvincaminic acid amides and their salts of formula (I) are new: (where either A and B = H and R = H or a group (II) or A and B together form a bond and R is a group (I)-(CH2)n- m = 1-4 and n = 0-3). I are used for treatment of disorders caused by anoxia, esp. of the central nervous system. I are prepd. from an apovincaminic or desoxyvincaminic acid halide by treatment with the amine RNH2. a nonpolar solvent opt. contg. an acid acceptor e.g. a tert org. base.
FR7516290A 1974-09-24 1975-05-26 Apovincaminic and desoxyvincaminic acid amides - of cycloalkyl amines for treatment of anoxic disorders Granted FR2312245A1 (en)

Priority Applications (19)

Application Number Priority Date Filing Date Title
FI751840*A FI751840A (en) 1974-09-24 1975-05-19
FR7516290A FR2312245A1 (en) 1975-05-26 1975-05-26 Apovincaminic and desoxyvincaminic acid amides - of cycloalkyl amines for treatment of anoxic disorders
SE7507088A SE7507088L (en) 1974-09-24 1975-06-19 APOVINKAMIN AND DESOXIVINKAMINIC ACID AMIDES
NO752192A NO752192L (en) 1974-09-24 1975-06-19
DK277975AA DK138427B (en) 1974-09-24 1975-06-19 Analogous process for the preparation of amides of apovincamine and deoxyvincamic acid or acid addition salts thereof.
ES75438799A ES438799A1 (en) 1974-09-24 1975-06-23 Vincaminic acid amides
IE1391/75A IE41260B1 (en) 1974-09-24 1975-06-23 Vincaminic acid amides
US05/589,088 US4011330A (en) 1974-09-24 1975-06-23 Vincaminic acid amides
LU72792A LU72792A1 (en) 1974-09-24 1975-06-24
CH818075A CH603651A5 (en) 1974-09-24 1975-06-24
DE2528609A DE2528609C3 (en) 1974-09-24 1975-06-26 Deoxyvincamineamides, their salts with acids, process for their preparation and pharmaceuticals
DE2559558A DE2559558C3 (en) 1975-05-26 1975-06-26 Apovincamineamides, their salts with acids, processes for their preparation and medicaments containing these compounds
CA230,244A CA1031344A (en) 1974-09-24 1975-06-26 Process for preparing vincaminic acid amines
GB2736975A GB1460235A (en) 1974-09-24 1975-06-27 Vincaminic acid amides
JP50079923A JPS5139699A (en) 1974-09-24 1975-06-27 Abopinkaminsan oyobi deokishibinkaminsannoamidonoseiho
IL47590A IL47590A (en) 1974-09-24 1975-06-27 Desoxyvincaminic acid and apovincaminic acid amides,their preparation and pharmaceutical compositions containing them
AU82571/75A AU491040B2 (en) 1975-06-30 Vincaminic acid amides
NL7508740A NL7508740A (en) 1974-09-24 1975-07-22 PROCESS FOR THE PREPARATION OF THE AMIDES OF APO-VINCAMIC ACID AND OF DESOXYVINCAMIC ACID AND PROCESS FOR THE PREPARATION OF PREPARATIONS CONTAINING THESE COMPOUNDS.
JP656176A JPS51141898A (en) 1975-05-26 1976-01-23 Amide of apobincamic acid and deoxybincamic acid

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7516290A FR2312245A1 (en) 1975-05-26 1975-05-26 Apovincaminic and desoxyvincaminic acid amides - of cycloalkyl amines for treatment of anoxic disorders

Publications (2)

Publication Number Publication Date
FR2312245A1 true FR2312245A1 (en) 1976-12-24
FR2312245B1 FR2312245B1 (en) 1979-08-10

Family

ID=9155657

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7516290A Granted FR2312245A1 (en) 1974-09-24 1975-05-26 Apovincaminic and desoxyvincaminic acid amides - of cycloalkyl amines for treatment of anoxic disorders

Country Status (2)

Country Link
DE (1) DE2559558C3 (en)
FR (1) FR2312245A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2869034A1 (en) * 2004-04-14 2005-10-21 Biocortech Soc Par Actions Sim 14,15-DIHYDRO 20,21-DINOREBURNAMENIN 14-OL DERIVATIVE AND THEIR USE FOR TREATING DEPRESSIONS

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
NEANT *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2869034A1 (en) * 2004-04-14 2005-10-21 Biocortech Soc Par Actions Sim 14,15-DIHYDRO 20,21-DINOREBURNAMENIN 14-OL DERIVATIVE AND THEIR USE FOR TREATING DEPRESSIONS
WO2005103047A1 (en) * 2004-04-14 2005-11-03 Biocortech Derivatives of 14.15-dihydro 20.21-dinoreburnamenin-14-ol, and applications thereof
US7354918B2 (en) 2004-04-14 2008-04-08 Biocortech Derivatives of 14.15-dihydro 20.21-dinoreburnamenin-14-ol and applications thereof

Also Published As

Publication number Publication date
FR2312245B1 (en) 1979-08-10
DE2559558C3 (en) 1980-07-10
DE2559558B2 (en) 1979-10-31
DE2559558A1 (en) 1977-02-17

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