FR2303010A1 - 4-Alkylidene-chromene-2-carboxylic acid derivs - and their oxidation to give 4-chromone-2-carboxylic acid cpds - Google Patents
4-Alkylidene-chromene-2-carboxylic acid derivs - and their oxidation to give 4-chromone-2-carboxylic acid cpdsInfo
- Publication number
- FR2303010A1 FR2303010A1 FR7511642A FR7511642A FR2303010A1 FR 2303010 A1 FR2303010 A1 FR 2303010A1 FR 7511642 A FR7511642 A FR 7511642A FR 7511642 A FR7511642 A FR 7511642A FR 2303010 A1 FR2303010 A1 FR 2303010A1
- Authority
- FR
- France
- Prior art keywords
- opt
- carboxylic acid
- chromene
- halogen
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
- C07D311/24—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyrane Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
4-Alkylidene-chromene-2-carboxylic acid derivs. of formula (II) (where R is H, halogen, lower alkyl (opt. mono- or polysubstd. by halogen, OH and/or lower alkoxy), or hydroxy (opt. etherified with a 3-5 C alkyl chain which may be substd. and/or by symmetrically linked via an ether linkage in the omega-position with a chromene structure of formula (II)); A is H, opt. substd. hydrocarbyl, NH4 or alkali(ne earth) metal; and R1 and R2 are H, lower alkyl, phenyl (opt. mono- or polysubstd. by halogen, OH, lower alkyl, lower haloalkyl, lower hydroxyalkyl and/or lower alkoxyalkyl) or cycloalkyl, or R1 and R2 are linked so as to form an alicyclic ring system), e.g. 4-benzylidene - DELTA2 - chromene-2-carboxylic acid methyl ester, are new cpds. Pref. (II; A = opt. unsaturated hydrocarbyl) may be treated with an oxidizing agent (the starting material or oxidation product opt. being converted into the free acid or into an ammonium or alkali(ne earth) salt) to give a 4-chromone-2-carboxylic acid cpd. of formula (I), e.g. 1,3-bis(2-carbomethoxy-4-chromono-5-yloxy)-2-hydroxypropane. (II) have oestrogenic or antioestrogenic activity. In addition, as indicated above, they are useful as intermediates for the known (DT 1543579) cpds. (I), which are useful for the treatment of disorders due to antigen-antibody reactions (esp. asthma and allergies).
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT21515/74A IT1044793B (en) | 1974-04-17 | 1974-04-17 | PREPARATION OF PIRANIC PASTIAL STRUCTURE COMPOUNDS |
Publications (1)
Publication Number | Publication Date |
---|---|
FR2303010A1 true FR2303010A1 (en) | 1976-10-01 |
Family
ID=11182945
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR7511642A Withdrawn FR2303010A1 (en) | 1974-04-17 | 1975-04-15 | 4-Alkylidene-chromene-2-carboxylic acid derivs - and their oxidation to give 4-chromone-2-carboxylic acid cpds |
Country Status (17)
Country | Link |
---|---|
JP (1) | JPS50137981A (en) |
BG (1) | BG24672A3 (en) |
DD (1) | DD121935A5 (en) |
DE (1) | DE2516623A1 (en) |
DK (1) | DK165975A (en) |
ES (1) | ES436627A1 (en) |
FI (1) | FI751145A (en) |
FR (1) | FR2303010A1 (en) |
IL (1) | IL47083A0 (en) |
IN (1) | IN142206B (en) |
IT (1) | IT1044793B (en) |
LU (1) | LU72297A1 (en) |
NL (1) | NL7504598A (en) |
NO (1) | NO751362L (en) |
RO (1) | RO72847A (en) |
SE (1) | SE7504342L (en) |
ZA (1) | ZA752432B (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2092438A1 (en) * | 1993-09-08 | 1996-11-16 | Dong Kook Pharm Co Ltd | Process for producing ortho-isopropylated phenol derivatives |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3722886A1 (en) * | 1987-07-10 | 1989-01-19 | Basf Ag | METHOD FOR THE PRODUCTION OF (ALPHA), SS-SUBSTITUTED ACROLEINS AND NEW SUBSTITUTED ACROLEINS |
-
1974
- 1974-04-17 IT IT21515/74A patent/IT1044793B/en active
-
1975
- 1975-04-14 IN IN740/CAL/75A patent/IN142206B/en unknown
- 1975-04-14 IL IL47083A patent/IL47083A0/en unknown
- 1975-04-15 RO RO7581993A patent/RO72847A/en unknown
- 1975-04-15 FR FR7511642A patent/FR2303010A1/en not_active Withdrawn
- 1975-04-15 SE SE7504342A patent/SE7504342L/en unknown
- 1975-04-16 NO NO751362A patent/NO751362L/no unknown
- 1975-04-16 DE DE19752516623 patent/DE2516623A1/en active Pending
- 1975-04-16 ES ES436627A patent/ES436627A1/en not_active Expired
- 1975-04-16 LU LU72297A patent/LU72297A1/xx unknown
- 1975-04-16 ZA ZA00752432A patent/ZA752432B/en unknown
- 1975-04-17 FI FI751145A patent/FI751145A/fi not_active Application Discontinuation
- 1975-04-17 NL NL7504598A patent/NL7504598A/en unknown
- 1975-04-17 DK DK165975A patent/DK165975A/en not_active IP Right Cessation
- 1975-04-17 BG BG7500029697A patent/BG24672A3/en unknown
- 1975-04-17 JP JP50045909A patent/JPS50137981A/ja active Pending
- 1975-04-17 DD DD185515A patent/DD121935A5/xx unknown
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2092438A1 (en) * | 1993-09-08 | 1996-11-16 | Dong Kook Pharm Co Ltd | Process for producing ortho-isopropylated phenol derivatives |
Also Published As
Publication number | Publication date |
---|---|
DD121935A5 (en) | 1976-09-05 |
JPS50137981A (en) | 1975-11-01 |
SE7504342L (en) | 1975-10-20 |
RO72847A (en) | 1983-07-07 |
BG24672A3 (en) | 1978-04-12 |
ZA752432B (en) | 1976-09-29 |
DE2516623A1 (en) | 1975-10-23 |
FI751145A (en) | 1975-10-18 |
DK165975A (en) | 1975-10-18 |
NO751362L (en) | 1975-10-20 |
NL7504598A (en) | 1975-10-21 |
IN142206B (en) | 1977-06-11 |
IL47083A0 (en) | 1975-06-25 |
ES436627A1 (en) | 1977-05-01 |
IT1044793B (en) | 1980-04-21 |
RO72847B (en) | 1983-06-30 |
LU72297A1 (en) | 1975-08-20 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
ST | Notification of lapse |