FR22C1039I2 - CAPSULAR POLYSACCHARIDES FROM STREPTOCOCCUS PNEUMONIAE AND CONJUGATE THEREOF - Google Patents

CAPSULAR POLYSACCHARIDES FROM STREPTOCOCCUS PNEUMONIAE AND CONJUGATE THEREOF

Info

Publication number
FR22C1039I2
FR22C1039I2 FR22C1039C FR22C1039C FR22C1039I2 FR 22C1039 I2 FR22C1039 I2 FR 22C1039I2 FR 22C1039 C FR22C1039 C FR 22C1039C FR 22C1039 C FR22C1039 C FR 22C1039C FR 22C1039 I2 FR22C1039 I2 FR 22C1039I2
Authority
FR
France
Prior art keywords
conjugate
streptococcus pneumoniae
capsular polysaccharides
capsular
polysaccharides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
FR22C1039C
Other languages
French (fr)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc filed Critical Pfizer Inc
Publication of FR22C1039I1 publication Critical patent/FR22C1039I1/en
Application granted granted Critical
Publication of FR22C1039I2 publication Critical patent/FR22C1039I2/en
Active legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
    • A61K39/092—Streptococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/385—Haptens or antigens, bound to carriers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0003—General processes for their isolation or fractionation, e.g. purification or extraction from biomass
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505—Inorganic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A61K2039/575—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 humoral response
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A61K2039/6037—Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A61K2039/6068—Other bacterial proteins, e.g. OMP
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/70—Multivalent vaccine
FR22C1039C 2014-01-21 2022-07-28 CAPSULAR POLYSACCHARIDES FROM STREPTOCOCCUS PNEUMONIAE AND CONJUGATE THEREOF Active FR22C1039I2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201461929598P 2014-01-21 2014-01-21
PCT/IB2015/050314 WO2015110940A2 (en) 2014-01-21 2015-01-15 Streptococcus pneumoniae capsular polysaccharides and conjugates thereof

Publications (2)

Publication Number Publication Date
FR22C1039I1 FR22C1039I1 (en) 2022-09-09
FR22C1039I2 true FR22C1039I2 (en) 2023-05-26

Family

ID=52630419

Family Applications (1)

Application Number Title Priority Date Filing Date
FR22C1039C Active FR22C1039I2 (en) 2014-01-21 2022-07-28 CAPSULAR POLYSACCHARIDES FROM STREPTOCOCCUS PNEUMONIAE AND CONJUGATE THEREOF

Country Status (21)

Country Link
US (4) US10105431B2 (en)
EP (2) EP3096783B1 (en)
JP (4) JP6612260B2 (en)
KR (2) KR102049826B1 (en)
CN (2) CN105934251A (en)
AU (2) AU2015208820B2 (en)
BR (1) BR112016015835B1 (en)
CA (1) CA2937184A1 (en)
DK (1) DK3096783T3 (en)
ES (1) ES2883343T3 (en)
FR (1) FR22C1039I2 (en)
HK (1) HK1223273A1 (en)
HR (1) HRP20211337T1 (en)
HU (1) HUE055408T2 (en)
IL (5) IL283554B (en)
MX (1) MX371454B (en)
PL (1) PL3096783T3 (en)
PT (1) PT3096783T (en)
RU (1) RU2710393C2 (en)
SI (1) SI3096783T1 (en)
WO (1) WO2015110940A2 (en)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT3096783T (en) * 2014-01-21 2021-08-16 Pfizer Streptococcus pneumoniae capsular polysaccharides and conjugates thereof
US11160855B2 (en) * 2014-01-21 2021-11-02 Pfizer Inc. Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof
WO2017013548A1 (en) * 2015-07-21 2017-01-26 Pfizer Inc. Immunogenic compositions comprising conjugated capsular saccharide antigens, kits comprising the same and uses thereof
CA3005524C (en) * 2015-11-20 2023-10-10 Pfizer Inc. Immunogenic compositions for use in pneumococcal vaccines
BR112019001971A2 (en) 2016-08-05 2019-05-07 Sanofi Pasteur, Inc. multivalent pneumococcal polysaccharide-protein conjugate composition
WO2018027123A1 (en) 2016-08-05 2018-02-08 Sanofi Pasteur, Inc. Multivalent pneumococcal polysaccharide-protein conjugate composition
CA3048981A1 (en) * 2016-12-30 2018-07-05 Sutrovax, Inc. Polypeptide-antigen conjugates with non-natural amino acids
US11951165B2 (en) 2016-12-30 2024-04-09 Vaxcyte, Inc. Conjugated vaccine carrier proteins
US11197921B2 (en) 2017-01-31 2021-12-14 Merck Sharp & Dohme Corp. Methods for making polysaccharide-protein conjugates
CN110337307A (en) 2017-02-24 2019-10-15 默沙东公司 Enhance streptococcus pneumoniae polysaccharides-protein conjugate immunogenicity
US20200054740A1 (en) * 2017-02-24 2020-02-20 Merck Sharp & Dohme Corp. Pneumococcal conjugate vaccine formulations
CN111132691A (en) 2017-06-10 2020-05-08 创赏有限公司 Multivalent conjugate vaccines with divalent or multivalent conjugate polysaccharides providing improved immunogenicity and avidity
US10729763B2 (en) 2017-06-10 2020-08-04 Inventprise, Llc Mixtures of polysaccharide-protein pegylated compounds
MX2020002557A (en) 2017-09-07 2020-07-13 Merck Sharp & Dohme Pneumococcal polysaccharides and their use in immunogenic polysaccharide-carrier protein conjugates.
US11524076B2 (en) * 2017-09-07 2022-12-13 Merck Sharp & Dohme Llc Pneumococcal polysaccharides and their use in immunogenic polysaccharide-carrier protein conjugates
EP3678652A4 (en) 2017-09-07 2021-05-19 Merck Sharp & Dohme Corp. Pneumococcal polysaccharides and their use in immunogenic polysaccharide-carrier protein conjugates
MX2020002555A (en) * 2017-09-07 2020-09-25 Merck Sharp & Dohme Pneumococcal polysaccharides and their use in immunogenic polysaccharide-carrier protein conjugates.
US10246715B1 (en) * 2017-10-02 2019-04-02 National Health Research Institutes CpG-oligodeoxynucleotide, immunogenic composition including the same, and method of inducing immune response by the same
MA51049A (en) 2017-12-06 2020-10-14 Merck Sharp & Dohme COMPOSITIONS COMPRISING STREPTOCOCCUS PNEUMONIAE POLYSACCHARIDE-PROTEIN CONJUGATES AND METHODS OF USE THEREOF
CA3087572A1 (en) 2018-02-05 2019-08-08 Sanofi Pasteur Inc. Multivalent pneumococcal polysaccharide-protein conjugate composition
MX2020008198A (en) 2018-02-05 2020-09-22 Sanofi Pasteur Inc Multivalent pneumococcal polysaccharide-protein conjugate composition.
CA3096358A1 (en) 2018-04-18 2019-10-24 Sk Bioscience Co., Ltd. Streptococcus pneumoniae capsular polysaccharide and immunogenic conjugate thereof
EP3788143B1 (en) 2018-04-30 2023-06-28 Merck Sharp & Dohme LLC Methods for providing a homogenous solution of lyophilized mutant diptheria toxin in dimethylsulfoxide
WO2019212846A1 (en) * 2018-04-30 2019-11-07 Merck Sharp & Dohme Corp. Methods for producing streptococcus pneumoniae capsular polysaccharide carrier protein conjugates
WO2020009993A1 (en) 2018-07-04 2020-01-09 Sutrovax, Inc. Improvements in immunogenic conjugates
WO2020121159A1 (en) * 2018-12-12 2020-06-18 Pfizer Inc. Immunogenic multiple hetero-antigen polysaccharide-protein conjugates and uses thereof
BR112021011961A8 (en) 2018-12-19 2023-02-07 Merck Sharp & Dohme COMPOSITIONS COMPRISING POLYSACCHARIDE-PROTEIN CONJUGATES OF STREPTOCOCCUS PNEUMONIAE AND METHODS OF USE THEREOF
JP7239509B6 (en) 2019-02-22 2023-03-28 ファイザー・インク Method for purifying bacterial polysaccharides
AU2021224078B2 (en) 2020-02-21 2024-01-18 Pfizer Inc. Purification of saccharides
US20230383324A1 (en) 2020-10-22 2023-11-30 Pfizer Inc. Methods for purifying bacterial polysaccharides
US20230405137A1 (en) 2020-11-10 2023-12-21 Pfizer Inc. Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof
CA3221075A1 (en) 2021-05-28 2022-12-01 Pfizer Inc. Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof

Family Cites Families (94)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4709017A (en) 1985-06-07 1987-11-24 President And Fellows Of Harvard College Modified toxic vaccines
US4950740A (en) 1987-03-17 1990-08-21 Cetus Corporation Recombinant diphtheria vaccines
US5057540A (en) 1987-05-29 1991-10-15 Cambridge Biotech Corporation Saponin adjuvant
US4912094B1 (en) 1988-06-29 1994-02-15 Ribi Immunochem Research Inc. Modified lipopolysaccharides and process of preparation
DE3841091A1 (en) 1988-12-07 1990-06-13 Behringwerke Ag SYNTHETIC ANTIGENS, METHOD FOR THEIR PRODUCTION AND THEIR USE
ES2055785T3 (en) 1989-01-17 1994-09-01 Eniricerche Spa SYNTHETIC PEPTIDES AND THEIR USE AS UNIVERSAL VEHICLES FOR THE PREPARATION OF IMMUNOGENOUS CONJUGATES SUITABLE FOR THE DEVELOPMENT OF SYNTHETIC VACCINES.
WO1990014837A1 (en) 1989-05-25 1990-12-13 Chiron Corporation Adjuvant formulation comprising a submicron oil droplet emulsion
CA2063271A1 (en) 1989-07-14 1991-01-15 Subramonia Pillai Cytokine and hormone carriers for conjugate vaccines
IT1237764B (en) 1989-11-10 1993-06-17 Eniricerche Spa SYNTHETIC PEPTIDES USEFUL AS UNIVERSAL CARRIERS FOR THE PREPARATION OF IMMUNOGENIC CONJUGATES AND THEIR USE FOR THE DEVELOPMENT OF SYNTHETIC VACCINES.
SE466259B (en) 1990-05-31 1992-01-20 Arne Forsgren PROTEIN D - AN IGD BINDING PROTEIN FROM HAEMOPHILUS INFLUENZAE, AND THE USE OF THIS FOR ANALYSIS, VACCINES AND PURPOSE
IL98715A0 (en) 1990-08-13 1992-07-15 American Cyanamid Co Filamentous hemaglutinin of bodetella pertussis as a carrier molecule for conjugate vaccines
IL101715A (en) 1991-05-02 2005-06-19 Amgen Inc Recombinant dna-derived cholera toxin subunit analogs
US5371197A (en) * 1991-09-24 1994-12-06 Merck & Co., Inc. Protein-dimeric polysaccharide conjugate vaccine
JPH07507854A (en) 1991-12-23 1995-08-31 ツォッヒェ，ミヒャエル Engine with oil removal device
IT1262896B (en) 1992-03-06 1996-07-22 CONJUGATE COMPOUNDS FORMED FROM HEAT SHOCK PROTEIN (HSP) AND OLIGO-POLY-SACCHARIDES, THEIR USE FOR THE PRODUCTION OF VACCINES.
JP3506431B2 (en) 1992-05-06 2004-03-15 プレジデント アンド フェローズ オブ ハーバード カレッジ Diphtheria toxin receptor binding domain
IL102687A (en) 1992-07-30 1997-06-10 Yeda Res & Dev Conjugates of poorly immunogenic antigens and synthetic pepide carriers and vaccines comprising them
ES2231770T3 (en) 1993-03-05 2005-05-16 Wyeth Holdings Corporation NEW PLASMIDS FOR THE PRODUCTION OF CRM PROTEIN AND DIFTERIC TOXIN.
US6455673B1 (en) 1994-06-08 2002-09-24 President And Fellows Of Harvard College Multi-mutant diphtheria toxin vaccines
US5917017A (en) 1994-06-08 1999-06-29 President And Fellows Of Harvard College Diphtheria toxin vaccines bearing a mutated R domain
US6239116B1 (en) 1994-07-15 2001-05-29 University Of Iowa Research Foundation Immunostimulatory nucleic acid molecules
CA2560114A1 (en) 1994-07-15 1996-02-01 The University Of Iowa Research Foundation Immunomodulatory oligonucleotides
US6207646B1 (en) 1994-07-15 2001-03-27 University Of Iowa Research Foundation Immunostimulatory nucleic acid molecules
US5565204A (en) * 1994-08-24 1996-10-15 American Cyanamid Company Pneumococcal polysaccharide-recombinant pneumolysin conjugate vaccines for immunization against pneumococcal infections
WO1998037919A1 (en) 1997-02-28 1998-09-03 University Of Iowa Research Foundation USE OF NUCLEIC ACIDS CONTAINING UNMETHYLATED CpG DINUCLEOTIDE IN THE TREATMENT OF LPS-ASSOCIATED DISORDERS
US6113918A (en) 1997-05-08 2000-09-05 Ribi Immunochem Research, Inc. Aminoalkyl glucosamine phosphate compounds and their use as adjuvants and immunoeffectors
CA2301575C (en) 1997-05-20 2003-12-23 Ottawa Civic Hospital Loeb Research Institute Vectors and methods for immunization or therapeutic protocols
GB9713156D0 (en) 1997-06-20 1997-08-27 Microbiological Res Authority Vaccines
US6218371B1 (en) 1998-04-03 2001-04-17 University Of Iowa Research Foundation Methods and products for stimulating the immune system using immunotherapeutic oligonucleotides and cytokines
CA2344740C (en) 1998-09-30 2011-11-22 American Cyanamid Company Mutant cholera holotoxin as an adjuvant
CA2355364C (en) 1998-12-21 2014-03-18 Medimmune, Inc. Streptococcus pneumoniae proteins and immunogenic fragments for vaccines
CZ303675B6 (en) 1998-12-23 2013-02-27 Id Biomedical Corporation Of Quebec Isolated polynucleotide, vector, host cell, production process, isolated polypeptide, chimeric polypeptide, vaccine composition and use
AR022963A1 (en) * 1999-03-19 2002-09-04 Smithkline Beecham Biolog VACCINE
US6936258B1 (en) 1999-03-19 2005-08-30 Nabi Biopharmaceuticals Staphylococcus antigen and vaccine
WO2000061761A2 (en) 1999-04-09 2000-10-19 Techlab, Inc. Recombinant clostridium toxin a protein carrier for polysaccharide conjugate vaccines
GB0007432D0 (en) 2000-03-27 2000-05-17 Microbiological Res Authority Proteins for use as carriers in conjugate vaccines
JP5051959B2 (en) 2000-06-20 2012-10-17 アイディー バイオメディカル コーポレイション オブ ケベック Streptococcus antigen
GB0108364D0 (en) * 2001-04-03 2001-05-23 Glaxosmithkline Biolog Sa Vaccine composition
WO2002091998A2 (en) 2001-05-11 2002-11-21 Aventis Pasteur, Inc. Novel meningitis conjugate vaccine
ATE451386T1 (en) 2001-06-07 2009-12-15 Wyeth Corp MUTANT FORMS OF CHOLERA HOLOTOXIN AS ADJUVANTS
WO2002098369A2 (en) 2001-06-07 2002-12-12 Wyeth Holdings Corporation Mutant forms of cholera holotoxin as an adjuvant
AU2002347404A1 (en) 2001-09-14 2003-04-01 Cytos Biotechnology Ag In vivo activation of antigen presenting cells for enhancement of immune responses induced by virus like particles
EP1456231A2 (en) 2001-12-20 2004-09-15 Shire Biochem Inc. Streptococcus antigens
US20040096461A1 (en) * 2002-07-30 2004-05-20 Baxter Healthcare Corporation Chimeric multivalent polysaccharide conjugate vaccines
NZ541969A (en) 2003-03-13 2008-01-31 Glaxosmithkline Biolog Sa Purifying pneumolysin from Streptococcus pneumoniae in a single chromatographic step by binding it to a hydrophobic interaction column in the presence of detergent and high salt
US8048432B2 (en) * 2003-08-06 2011-11-01 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Polysaccharide-protein conjugate vaccines
BRPI0413309B8 (en) * 2003-08-06 2021-05-25 The Government Of The Us Secretary Department Of Health And Human Services method for preparing a polysaccharide-protein conjugate vaccine
GB0323103D0 (en) 2003-10-02 2003-11-05 Chiron Srl De-acetylated saccharides
US20050118199A1 (en) * 2003-10-07 2005-06-02 Esser Mark T. Process for covalently conjugating polysaccharides to microspheres or biomolecules
KR100958505B1 (en) 2004-07-18 2010-05-17 씨에스엘 리미티드 Immuno stimulating complex and oligonucleotide formulations for inducing enhanced interferon-gamma responses
IL308456A (en) * 2005-04-08 2024-01-01 Wyeth Llc Multivalent pneumococcal polysacharide-protein conjugate composition
US7955605B2 (en) 2005-04-08 2011-06-07 Wyeth Llc Multivalent pneumococcal polysaccharide-protein conjugate composition
PL3466982T3 (en) 2005-04-08 2020-11-02 Wyeth Llc Separation of contaminants from streptococcus pneumoniae polysaccharide by ph manipulation
US20070184072A1 (en) * 2005-04-08 2007-08-09 Wyeth Multivalent pneumococcal polysaccharide-protein conjugate composition
US7709001B2 (en) * 2005-04-08 2010-05-04 Wyeth Llc Multivalent pneumococcal polysaccharide-protein conjugate composition
CA2816182C (en) * 2005-12-22 2018-02-20 Glaxosmithkline Biologicals S.A. Pneumococcal polysaccharide conjugate vaccine
ES2658851T3 (en) * 2006-08-07 2018-03-12 President And Fellows Of Harvard College Protein matrix vaccines and methods of preparation and administration of such vaccines
ATE473289T1 (en) 2006-10-10 2010-07-15 Wyeth Llc IMPROVED METHODS FOR SEPARATION OF STREPTOCOCCUS PNEUMONIAE-3-POLYSACCHARIDES
BRPI0717219B8 (en) * 2006-10-12 2021-05-25 Glaxosmithkline Biologicals Sa immunogenic composition, and, use of an immunogenic composition
SI2436700T1 (en) 2007-03-23 2018-09-28 Wyeth Llc Shortened purification process for the production of capsular streptococcus pneumoniae polysaccharides
ES2621359T3 (en) * 2007-06-20 2017-07-03 Pfizer Ireland Pharmaceuticals Modified polysaccharides for conjugate vaccines
KR101579947B1 (en) * 2007-06-26 2015-12-28 글락소스미스클라인 바이오로지칼즈 에스.에이. Vaccine comprising streptococcus pneumoniae capsular polysaccharide conjugates
BRPI0915825A2 (en) * 2008-07-08 2015-11-03 Abbott Lab prostaglandin binding proteins and uses thereof
RU2536248C2 (en) 2009-04-30 2014-12-20 Коули Фармасьютикал Груп, Инк. Pneumococcal vaccine and using it
TW201136603A (en) * 2010-02-09 2011-11-01 Merck Sharp & Amp Dohme Corp 15-valent pneumococcal polysaccharide-protein conjugate vaccine composition
GB201003924D0 (en) * 2010-03-09 2010-04-21 Glaxosmithkline Biolog Sa Immunogenic composition
GB201003922D0 (en) * 2010-03-09 2010-04-21 Glaxosmithkline Biolog Sa Conjugation process
AU2011338723A1 (en) * 2010-12-10 2013-05-30 Merck Sharp & Dohme Corp. Novel formulations which mitigate agitation-induced aggregation of immunogenic compositions
GB201103836D0 (en) * 2011-03-07 2011-04-20 Glaxosmithkline Biolog Sa Conjugation process
GB201106225D0 (en) * 2011-04-13 2011-05-25 Glaxosmithkline Biolog Sa Fermentation process
KR102057217B1 (en) * 2012-06-20 2020-01-22 에스케이바이오사이언스 주식회사 Multivalent pneumococcal polysaccharide-protein conjugate composition
PT3421051T (en) * 2012-08-16 2020-06-26 Pfizer Glycoconjugation processes and compositions
KR101944960B1 (en) * 2012-09-07 2019-02-07 에스케이바이오사이언스 주식회사 Process for preparing a capsular polysaccharide having a serotype of Streptococcus pneumoniae
US20140105927A1 (en) * 2012-10-17 2014-04-17 Glaxosmithkline Biologicals S.A. Immunogenic composition
GB201218660D0 (en) * 2012-10-17 2012-11-28 Glaxosmithkline Biolog Sa Immunogenic composition
US20140193451A1 (en) * 2012-10-17 2014-07-10 Glaxosmithkline Biologicals Sa Immunogenic composition
KR20140075201A (en) * 2012-12-11 2014-06-19 에스케이케미칼주식회사 Multivalent pneumococcal polysaccharide-protein conjugate composition
DK3363806T3 (en) * 2012-12-20 2022-11-21 Pfizer Glycoconjugation method
ITMI20130142A1 (en) * 2013-01-31 2014-08-01 Biosynth Srl GLYCOCOUGUGAR VACCINES INCLUDING BASIC UNITS OF AN EXPRIMENT MOLECULAR CONSTRUCTED MULTIPLE EPITHOPES INCORPORATED
US11160855B2 (en) * 2014-01-21 2021-11-02 Pfizer Inc. Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof
US20160324949A1 (en) * 2014-01-21 2016-11-10 Pfizer Inc. Streptococcus pneumoniae capsular polysaccharides and conjugates thereof
PT3096783T (en) * 2014-01-21 2021-08-16 Pfizer Streptococcus pneumoniae capsular polysaccharides and conjugates thereof
CN114887048A (en) * 2014-01-21 2022-08-12 辉瑞公司 Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof
EP3104886B1 (en) * 2014-02-14 2018-10-17 Pfizer Inc Immunogenic glycoprotein conjugates
US9631328B2 (en) * 2014-03-12 2017-04-25 Permavoid Limited Sports field structure and modules and method for forming the same
BR112017013891B1 (en) * 2015-01-15 2024-01-30 Pfizer Inc IMMUNOGENIC COMPOSITIONS FOR USE IN PNEUMOCOCCAL VACCINES
NZ736238A (en) * 2015-05-04 2022-07-01 Pfizer Group b streptococcus polysaccharide-protein conjugates, methods for producing conjugates, immunogenic compositions comprising conjugates, and uses thereof
WO2017013548A1 (en) * 2015-07-21 2017-01-26 Pfizer Inc. Immunogenic compositions comprising conjugated capsular saccharide antigens, kits comprising the same and uses thereof
US10751402B2 (en) * 2016-11-09 2020-08-25 Pfizer Inc. Immunogenic compositions and uses thereof
HRP20220573T1 (en) * 2017-01-20 2022-06-10 Pfizer Inc. Immunogenic compositions for use in pneumococcal vaccines
CN110337307A (en) * 2017-02-24 2019-10-15 默沙东公司 Enhance streptococcus pneumoniae polysaccharides-protein conjugate immunogenicity
CN111065388A (en) * 2017-09-07 2020-04-24 默沙东公司 Pneumococcal polysaccharides and their use in immunogenic polysaccharide-carrier protein conjugates
US11524076B2 (en) * 2017-09-07 2022-12-13 Merck Sharp & Dohme Llc Pneumococcal polysaccharides and their use in immunogenic polysaccharide-carrier protein conjugates
MA51049A (en) * 2017-12-06 2020-10-14 Merck Sharp & Dohme COMPOSITIONS COMPRISING STREPTOCOCCUS PNEUMONIAE POLYSACCHARIDE-PROTEIN CONJUGATES AND METHODS OF USE THEREOF

Also Published As

Publication number Publication date
CN112168957A (en) 2021-01-05
EP3957321A3 (en) 2022-07-13
US11426456B2 (en) 2022-08-30
IL270764A (en) 2020-01-30
JP2020055810A (en) 2020-04-09
IL270764B (en) 2021-04-29
KR20190132580A (en) 2019-11-27
WO2015110940A2 (en) 2015-07-30
DK3096783T3 (en) 2021-08-02
RU2016126846A3 (en) 2018-02-28
RU2710393C2 (en) 2019-12-26
JP2017504660A (en) 2017-02-09
JP6947788B2 (en) 2021-10-13
AU2020204254A1 (en) 2020-07-16
CN105934251A (en) 2016-09-07
JP2020109072A (en) 2020-07-16
BR112016015835A2 (en) 2017-09-19
IL283554B (en) 2022-08-01
BR112016015835B1 (en) 2023-12-26
MX2016009468A (en) 2016-10-13
IL270760B (en) 2021-06-30
EP3096783A2 (en) 2016-11-30
AU2015208820B2 (en) 2020-05-14
WO2015110940A3 (en) 2015-11-26
IL270761A (en) 2020-01-30
HRP20211337T1 (en) 2021-11-26
PT3096783T (en) 2021-08-16
US10105431B2 (en) 2018-10-23
US20160324948A1 (en) 2016-11-10
HK1223273A1 (en) 2017-07-28
EP3096783B1 (en) 2021-07-07
EP3957321A2 (en) 2022-02-23
JP6594581B2 (en) 2019-10-23
AU2020204254B2 (en) 2022-06-02
KR102049826B1 (en) 2019-12-03
US20190000953A1 (en) 2019-01-03
US10918708B2 (en) 2021-02-16
KR20160108539A (en) 2016-09-19
JP2019163312A (en) 2019-09-26
IL270760A (en) 2020-01-30
AU2015208820A1 (en) 2016-07-14
ES2883343T3 (en) 2021-12-07
KR102099741B1 (en) 2020-04-10
RU2016126846A (en) 2018-02-28
JP6612260B2 (en) 2019-11-27
HUE055408T2 (en) 2021-12-28
CA2937184A1 (en) 2015-07-30
US20210023193A1 (en) 2021-01-28
IL246652A0 (en) 2016-08-31
IL270761B (en) 2021-04-29
FR22C1039I1 (en) 2022-09-09
PL3096783T3 (en) 2021-12-13
SI3096783T1 (en) 2021-09-30
US20220378897A1 (en) 2022-12-01
JP6947789B2 (en) 2021-10-13
IL283554A (en) 2021-07-29
MX371454B (en) 2020-01-29

Similar Documents

Publication Publication Date Title
FR22C1039I2 (en) CAPSULAR POLYSACCHARIDES FROM STREPTOCOCCUS PNEUMONIAE AND CONJUGATE THEREOF
FR22C1041I2 (en) CAPSULAR POLYSACCHARIDES FROM STREPTOCOCCUS PNEUMONIAE AND THEIR CONJUGATES
IL258248A (en) Affinity-oligonucleotide conjugates and uses thereof
IL248961A0 (en) Auristatin derivatives and conjugates thereof
IL247344B (en) Novel polysaccharide and uses thereof
IL252015A0 (en) Antibody drug conjugates
DK3466976T3 (en) ANTI-HER2-ANTIBODY-MEDICINE CONJUGATE
IL250189A0 (en) Anti-cdh6 antibody drug conjugates
SG11201609490QA (en) Polymer-flavonoid conjugate and uses thereof
IL258759A (en) Anti-cd3-folate conjugates and their uses
DK3122378T3 (en) Mutant staphylococcal antigens
TH1601003807A (en) Anti-TROP2 antibody-drug conjugate
TH1501007546A (en) Hot stamping parts and their production methods
BR112016027254A2 (en) CHITIN-GLUCAN COMPLEX, ITS PREPARATION AND USES
ES1135587Y (en) Snoring Damper Mattress