FR2297048A1 - Antibacterial acylthiomethyl cephalosporin esters - readily absorbed from gastro-intestinal tract and then hydrolysed to free acid - Google Patents

Antibacterial acylthiomethyl cephalosporin esters - readily absorbed from gastro-intestinal tract and then hydrolysed to free acid

Info

Publication number
FR2297048A1
FR2297048A1 FR7500369A FR7500369A FR2297048A1 FR 2297048 A1 FR2297048 A1 FR 2297048A1 FR 7500369 A FR7500369 A FR 7500369A FR 7500369 A FR7500369 A FR 7500369A FR 2297048 A1 FR2297048 A1 FR 2297048A1
Authority
FR
France
Prior art keywords
phenyl
acylthiomethyl
gastro
hydrolysed
antibacterial
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7500369A
Other languages
French (fr)
Other versions
FR2297048B1 (en
Inventor
Hermann Breuer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ER Squibb and Sons LLC
Original Assignee
ER Squibb and Sons LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ER Squibb and Sons LLC filed Critical ER Squibb and Sons LLC
Priority to FR7500369A priority Critical patent/FR2297048A1/en
Publication of FR2297048A1 publication Critical patent/FR2297048A1/en
Application granted granted Critical
Publication of FR2297048B1 publication Critical patent/FR2297048B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

Title cpds of formula (I): (where R1=phenoxymethyl, phenyl-lower alkyl opt. alpha substd by amino, carboxy or ureido; R2=H, lower alkyl, phenyl or phenyl-lower alkyl; R3=lower alkyl, lower alkenyl, phenyl or phenyl-lower alkyl, and X=H, OH, or lower alkanoyloxy) and their acid addn. salts are prepd by reacting the appropriate cephalosporanic acid as its activated deriv. with acylmercapto methanol.
FR7500369A 1975-01-07 1975-01-07 Antibacterial acylthiomethyl cephalosporin esters - readily absorbed from gastro-intestinal tract and then hydrolysed to free acid Granted FR2297048A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR7500369A FR2297048A1 (en) 1975-01-07 1975-01-07 Antibacterial acylthiomethyl cephalosporin esters - readily absorbed from gastro-intestinal tract and then hydrolysed to free acid

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7500369A FR2297048A1 (en) 1975-01-07 1975-01-07 Antibacterial acylthiomethyl cephalosporin esters - readily absorbed from gastro-intestinal tract and then hydrolysed to free acid

Publications (2)

Publication Number Publication Date
FR2297048A1 true FR2297048A1 (en) 1976-08-06
FR2297048B1 FR2297048B1 (en) 1978-07-28

Family

ID=9149489

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7500369A Granted FR2297048A1 (en) 1975-01-07 1975-01-07 Antibacterial acylthiomethyl cephalosporin esters - readily absorbed from gastro-intestinal tract and then hydrolysed to free acid

Country Status (1)

Country Link
FR (1) FR2297048A1 (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1229453A (en) * 1968-01-30 1971-04-21

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1229453A (en) * 1968-01-30 1971-04-21

Also Published As

Publication number Publication date
FR2297048B1 (en) 1978-07-28

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