FR2294701A1 - BETA-LACTAMASE INHIBITORS AND PROCESS FOR THEIR PREPARATION - Google Patents

BETA-LACTAMASE INHIBITORS AND PROCESS FOR THEIR PREPARATION

Info

Publication number
FR2294701A1
FR2294701A1 FR7538284A FR7538284A FR2294701A1 FR 2294701 A1 FR2294701 A1 FR 2294701A1 FR 7538284 A FR7538284 A FR 7538284A FR 7538284 A FR7538284 A FR 7538284A FR 2294701 A1 FR2294701 A1 FR 2294701A1
Authority
FR
France
Prior art keywords
beta
lactamase inhibitors
preparation
compound
isomerisation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7538284A
Other languages
French (fr)
Other versions
FR2294701B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beecham Group PLC
Original Assignee
Beecham Group PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB54788/74A external-priority patent/GB1534508A/en
Application filed by Beecham Group PLC filed Critical Beecham Group PLC
Publication of FR2294701A1 publication Critical patent/FR2294701A1/en
Application granted granted Critical
Publication of FR2294701B1 publication Critical patent/FR2294701B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

Novel compounds of the formula I in which R is a hydrogen atom or an acyl radical, and their salts and esters are prepared by isomerisation of a compound which is isomeric with the compound I in respect of the CH2OR group located on the double bond. The compounds obtained have a pharmacological action as beta -lactamase inhibitors and are antibacterially active to a certain extent.
FR7538284A 1974-12-18 1975-12-15 BETA-LACTAMASE INHIBITORS AND PROCESS FOR THEIR PREPARATION Granted FR2294701A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB54788/74A GB1534508A (en) 1974-12-18 1974-12-18 Isoclavulanic acid derivatives
GB1521175 1975-04-14

Publications (2)

Publication Number Publication Date
FR2294701A1 true FR2294701A1 (en) 1976-07-16
FR2294701B1 FR2294701B1 (en) 1982-07-23

Family

ID=26251138

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7538284A Granted FR2294701A1 (en) 1974-12-18 1975-12-15 BETA-LACTAMASE INHIBITORS AND PROCESS FOR THEIR PREPARATION

Country Status (11)

Country Link
JP (1) JPS51138693A (en)
AU (1) AU500572B2 (en)
CA (1) CA1064039A (en)
CH (1) CH619230A5 (en)
DE (1) DE2555626A1 (en)
DK (1) DK142702B (en)
FR (1) FR2294701A1 (en)
IE (1) IE42370B1 (en)
IL (1) IL48607A (en)
NL (1) NL7514545A (en)
SE (1) SE428564B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2369281A1 (en) * 1976-10-30 1978-05-26 Beecham Group Ltd B-LACTAM CYCLE COMPOUNDS FOR USE AS MEDICINAL PRODUCTS

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2747599A1 (en) * 1976-10-25 1978-04-27 Glaxo Lab Ltd CLAVULANIC ACID DERIVATIVES, PROCESS FOR THEIR PREPARATION AND COMPOSITIONS THEREOF

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2369281A1 (en) * 1976-10-30 1978-05-26 Beecham Group Ltd B-LACTAM CYCLE COMPOUNDS FOR USE AS MEDICINAL PRODUCTS

Also Published As

Publication number Publication date
DK142702B (en) 1980-12-22
FR2294701B1 (en) 1982-07-23
SE428564B (en) 1983-07-11
IL48607A0 (en) 1976-02-29
DK142702C (en) 1981-08-10
CA1064039A (en) 1979-10-09
NL7514545A (en) 1976-06-22
IE42370B1 (en) 1980-07-30
JPS51138693A (en) 1976-11-30
DK574875A (en) 1976-06-19
DE2555626A1 (en) 1976-07-01
SE7514029L (en) 1976-06-21
IE42370L (en) 1976-06-18
IL48607A (en) 1979-07-25
AU8752175A (en) 1977-06-16
CH619230A5 (en) 1980-09-15
AU500572B2 (en) 1979-05-24

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Legal Events

Date Code Title Description
ST Notification of lapse