FR2278337A1 - Hydroxy-substd. thieno(3,2-c) - and - (2,3-c)pyridine derivs. - prepd. by cyclizing 2-(thienylmethylamino)-acetaldehyde dialkyl acetals - Google Patents
Hydroxy-substd. thieno(3,2-c) - and - (2,3-c)pyridine derivs. - prepd. by cyclizing 2-(thienylmethylamino)-acetaldehyde dialkyl acetalsInfo
- Publication number
- FR2278337A1 FR2278337A1 FR7424631A FR7424631A FR2278337A1 FR 2278337 A1 FR2278337 A1 FR 2278337A1 FR 7424631 A FR7424631 A FR 7424631A FR 7424631 A FR7424631 A FR 7424631A FR 2278337 A1 FR2278337 A1 FR 2278337A1
- Authority
- FR
- France
- Prior art keywords
- hydroxy
- substd
- thieno
- pyridine
- thienylmethylamino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
- C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/22—Radicals substituted by doubly bound hetero atoms, or by two hetero atoms other than halogen singly bound to the same carbon atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
Hydroxy-substd. thieno/3,2-c/- and -/2,3-c/pyridine derivs. of formulae (I) and (II) (where R is H or 1-6C alkyl), e.g. 7-hydroxy 4,5,6,7-tetrahydrothieno 3,2-c pyridine, and their addition salts with mineral and organic acids, are new cpds. (I) and (II) have anti-inflammatory, analgesic and platelet aggregation inhibiting activity. (I) and (II) have low toxicity and are well tolerated. Details and results of tests in animals are given in the specification; thus, (I; R = H) (LD50 75 mg/kg i.v. in mice) in a dosage of 3 x 100 mg/kg p.o. gives 41% (1 hr.), 48% (3 hrs) and 53% (5 hrs) inhibition of rat paw carrageenin oedema. (I) and (II) are also useful as intermediates for other cpds., e.g. pharmaceuticals.
Priority Applications (25)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7424631A FR2278337A1 (en) | 1974-07-16 | 1974-07-16 | Hydroxy-substd. thieno(3,2-c) - and - (2,3-c)pyridine derivs. - prepd. by cyclizing 2-(thienylmethylamino)-acetaldehyde dialkyl acetals |
AR259601A AR205040A1 (en) | 1974-07-16 | 1975-01-01 | PROCEDURE FOR THE PREPARATION OF TETRAHYDRO-4,5,6,7, -TIENO (3,2-C) O (2,3-C) PYRIDINE DERIVATIVES |
CH775175A CH605969A5 (en) | 1974-07-16 | 1975-06-16 | |
YU1620/75A YU39945B (en) | 1974-07-16 | 1975-06-25 | Process for obtaining new thieno-pyridine derivatives |
US05/593,051 US3983125A (en) | 1974-07-16 | 1975-07-03 | Thieno-pyridine derivatives, process for their preparation and their applications |
HUPA1219A HU170045B (en) | 1974-07-16 | 1975-07-04 | |
IL47654A IL47654A (en) | 1974-07-16 | 1975-07-07 | 7-hydroxy-4,5,6,7-tetrahydrothieno(3,2-c)-and 4-hydroxy-4,5,6,7-tetrahydrothieno(i8o-c)-pyridine derivatives their preparation and pharmaceutical compositions containing the |
AT523275A AT345834B (en) | 1974-07-16 | 1975-07-07 | PROCESS FOR PRODUCING NEW THIENOPYRIDINE DERIVATIVES |
ZA00754368A ZA754368B (en) | 1974-07-16 | 1975-07-08 | New thieno-pyridine derivatives, process for their preparation and their applications |
DE2530515A DE2530515C2 (en) | 1974-07-16 | 1975-07-09 | 4- and 7-hydroxy-4,5,6,7-tetrahydrothieno- [3,2-c] or [2,3-c] pyridines, processes for their preparation and pharmaceutical preparations containing them |
CA231,112A CA1068704A (en) | 1974-07-16 | 1975-07-09 | Process for the preparation of thieno-pyridine derivatives |
NLAANVRAGE7508153,A NL182961C (en) | 1974-07-16 | 1975-07-09 | PROCESS FOR PREPARING A PHARMACEUTICAL PREPARATION BASED ON THIENO-PYRIDINE DERIVATIVES AND METHOD FOR PREPARING THIENO-PYRIDINE DERIVATIVES |
PH17369A PH11045A (en) | 1974-07-16 | 1975-07-10 | Thieno-pyridine derivatives and therapeutic composition thereof |
DK316475AA DK136652B (en) | 1974-07-16 | 1975-07-11 | Process for the preparation of thieno-pyridine derivatives. |
SE7508025A SE417822B (en) | 1974-07-16 | 1975-07-14 | PROCEDURE FOR PREPARING TIENOPYRIDINE DERIVATIVES |
RO7582850A RO72839A (en) | 1974-07-16 | 1975-07-14 | PROCESS FOR THE PREPARATION OF THIENOPYRIDINE DERIVATIVES |
AU83062/75A AU492253B2 (en) | 1975-07-15 | new THIENO-PYRIDINE DERIVATIVES PROCESS FOR THEIR PREPARATION AND THEIR APPLICATIONS | |
SU7502151532A SU584785A3 (en) | 1974-07-16 | 1975-07-15 | Method of preparing thieno(3,2,-c)pyrimidine derivatives or salts thereof |
ES439431A ES439431A1 (en) | 1974-07-16 | 1975-07-15 | Thieno-pyridine derivatives, process for their preparation and their applications |
PL1975182080A PL101232B1 (en) | 1974-07-16 | 1975-07-15 | METHOD OF PRODUCTION OF NEW THENOPYRIDINE DERIVATIVES |
GB29700/75A GB1486646A (en) | 1974-07-16 | 1975-07-15 | Thieno-pyridine derivatives |
JP50087152A JPS5844674B2 (en) | 1974-07-16 | 1975-07-16 | Shinkithieno-Pyridine Yudo Taino Seizouhouhou |
BE158338A BE831416A (en) | 1974-07-16 | 1975-07-16 | NEW DERIVATIVES OF THIENO-PYRIDINE, THEIR PREPARATION PROCESS AND THEIR APPLICATIONS |
DD186799A DD119048A5 (en) | 1974-07-16 | 1975-07-16 | |
SU762379605A SU618045A3 (en) | 1974-07-16 | 1976-07-21 | Method of obtaining thieno (2,3-c) pyridine derivatives or salts thereof |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7424631A FR2278337A1 (en) | 1974-07-16 | 1974-07-16 | Hydroxy-substd. thieno(3,2-c) - and - (2,3-c)pyridine derivs. - prepd. by cyclizing 2-(thienylmethylamino)-acetaldehyde dialkyl acetals |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2278337A1 true FR2278337A1 (en) | 1976-02-13 |
FR2278337B1 FR2278337B1 (en) | 1978-07-28 |
Family
ID=9141311
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR7424631A Granted FR2278337A1 (en) | 1974-07-16 | 1974-07-16 | Hydroxy-substd. thieno(3,2-c) - and - (2,3-c)pyridine derivs. - prepd. by cyclizing 2-(thienylmethylamino)-acetaldehyde dialkyl acetals |
Country Status (6)
Country | Link |
---|---|
JP (1) | JPS5844674B2 (en) |
BE (1) | BE831416A (en) |
FR (1) | FR2278337A1 (en) |
HU (1) | HU170045B (en) |
SE (1) | SE417822B (en) |
ZA (1) | ZA754368B (en) |
-
1974
- 1974-07-16 FR FR7424631A patent/FR2278337A1/en active Granted
-
1975
- 1975-07-04 HU HUPA1219A patent/HU170045B/hu unknown
- 1975-07-08 ZA ZA00754368A patent/ZA754368B/en unknown
- 1975-07-14 SE SE7508025A patent/SE417822B/en not_active IP Right Cessation
- 1975-07-16 BE BE158338A patent/BE831416A/en not_active IP Right Cessation
- 1975-07-16 JP JP50087152A patent/JPS5844674B2/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
JPS5844674B2 (en) | 1983-10-04 |
HU170045B (en) | 1977-03-28 |
BE831416A (en) | 1976-01-16 |
SE7508025L (en) | 1976-01-19 |
SE417822B (en) | 1981-04-13 |
JPS5148692A (en) | 1976-04-26 |
ZA754368B (en) | 1976-06-30 |
FR2278337B1 (en) | 1978-07-28 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
CD | Change of name or company name | ||
ST | Notification of lapse |