FR2272681A1 - 6-(di) methylamino substd. cyclodextrin derivs - hypolipaemics prepd. from cyclodextrin, alkaryl sulphonyl chloride and (di) methylamine - Google Patents

6-(di) methylamino substd. cyclodextrin derivs - hypolipaemics prepd. from cyclodextrin, alkaryl sulphonyl chloride and (di) methylamine

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Publication number
FR2272681A1
FR2272681A1 FR7418856A FR7418856A FR2272681A1 FR 2272681 A1 FR2272681 A1 FR 2272681A1 FR 7418856 A FR7418856 A FR 7418856A FR 7418856 A FR7418856 A FR 7418856A FR 2272681 A1 FR2272681 A1 FR 2272681A1
Authority
FR
France
Prior art keywords
cyclodextrin
hypolipaemics
derivs
prepd
substd
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
FR7418856A
Other languages
French (fr)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tanabe Seiyaku Co Ltd
Original Assignee
Tanabe Seiyaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tanabe Seiyaku Co Ltd filed Critical Tanabe Seiyaku Co Ltd
Priority to FR7418856A priority Critical patent/FR2272681A1/en
Publication of FR2272681A1 publication Critical patent/FR2272681A1/en
Withdrawn legal-status Critical Current

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Classifications

    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08BPOLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0009Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
    • C08B37/0012Cyclodextrin [CD], e.g. cycle with 6 units (alpha), with 7 units (beta) and with 8 units (gamma), large-ring cyclodextrin or cycloamylose with 9 units or more; Derivatives thereof

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Materials Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

(A) Cyclodextrin derivs. of formula (I) and their pharm. tolerable acid addn. salts, (n = 6 or 7; R = CH3NH or (CH3)2N; R2 = mesitylsuphonyl or 2, 4, 6-triisopropylbenzenesulphonyl), are prepd. along with corresp. cpds. (I; R = NH2), by reacting corresp. cyclodextrin (-CH2R replaced by -CH2OH) with R2X (X = halo) in presence of an acid acceptor to give (I; R = OR2) then reacting with R3H(R3 = R, NH2 or N3) or its alkali metal salt at 30-100 degrees C. and, where R3 = N3, hydrogenating. (I), and unsubstd. amino cpds., are hypolipaemics esp. hypocholesterolaemics.
FR7418856A 1974-05-30 1974-05-30 6-(di) methylamino substd. cyclodextrin derivs - hypolipaemics prepd. from cyclodextrin, alkaryl sulphonyl chloride and (di) methylamine Withdrawn FR2272681A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR7418856A FR2272681A1 (en) 1974-05-30 1974-05-30 6-(di) methylamino substd. cyclodextrin derivs - hypolipaemics prepd. from cyclodextrin, alkaryl sulphonyl chloride and (di) methylamine

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7418856A FR2272681A1 (en) 1974-05-30 1974-05-30 6-(di) methylamino substd. cyclodextrin derivs - hypolipaemics prepd. from cyclodextrin, alkaryl sulphonyl chloride and (di) methylamine

Publications (1)

Publication Number Publication Date
FR2272681A1 true FR2272681A1 (en) 1975-12-26

Family

ID=9139478

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7418856A Withdrawn FR2272681A1 (en) 1974-05-30 1974-05-30 6-(di) methylamino substd. cyclodextrin derivs - hypolipaemics prepd. from cyclodextrin, alkaryl sulphonyl chloride and (di) methylamine

Country Status (1)

Country Link
FR (1) FR2272681A1 (en)

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