FR2266516A1 - Somatostatin peptide analogues having prolonged activity - inhibit secretion of pituitary growth hormone and glucagon and are used to treat diabetes - Google Patents
Somatostatin peptide analogues having prolonged activity - inhibit secretion of pituitary growth hormone and glucagon and are used to treat diabetesInfo
- Publication number
- FR2266516A1 FR2266516A1 FR7510392A FR7510392A FR2266516A1 FR 2266516 A1 FR2266516 A1 FR 2266516A1 FR 7510392 A FR7510392 A FR 7510392A FR 7510392 A FR7510392 A FR 7510392A FR 2266516 A1 FR2266516 A1 FR 2266516A1
- Authority
- FR
- France
- Prior art keywords
- ala
- glucagon
- growth hormone
- secretion
- peptide analogues
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 102000051325 Glucagon Human genes 0.000 title abstract 3
- 108060003199 Glucagon Proteins 0.000 title abstract 3
- 102000018997 Growth Hormone Human genes 0.000 title abstract 3
- 108010051696 Growth Hormone Proteins 0.000 title abstract 3
- 108010056088 Somatostatin Proteins 0.000 title abstract 3
- 230000000694 effects Effects 0.000 title abstract 3
- 229960004666 glucagon Drugs 0.000 title abstract 3
- MASNOZXLGMXCHN-ZLPAWPGGSA-N glucagon Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 MASNOZXLGMXCHN-ZLPAWPGGSA-N 0.000 title abstract 3
- 239000000122 growth hormone Substances 0.000 title abstract 3
- 230000028327 secretion Effects 0.000 title abstract 3
- 206010012601 diabetes mellitus Diseases 0.000 title abstract 2
- 230000002035 prolonged effect Effects 0.000 title abstract 2
- 102000005157 Somatostatin Human genes 0.000 abstract 2
- NHXLMOGPVYXJNR-ATOGVRKGSA-N somatostatin Chemical compound C([C@H]1C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C3=CC=CC=C3NC=2)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N1)[C@@H](C)O)NC(=O)CNC(=O)[C@H](C)N)C(O)=O)=O)[C@H](O)C)C1=CC=CC=C1 NHXLMOGPVYXJNR-ATOGVRKGSA-N 0.000 abstract 2
- 229960000553 somatostatin Drugs 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 229940088597 hormone Drugs 0.000 abstract 1
- 239000005556 hormone Substances 0.000 abstract 1
- 239000000492 insulin antagonist Substances 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 125000000896 monocarboxylic acid group Chemical group 0.000 abstract 1
- RGSFGYAAUTVSQA-UHFFFAOYSA-N pentamethylene Natural products C1CCCC1 RGSFGYAAUTVSQA-UHFFFAOYSA-N 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 238000001228 spectrum Methods 0.000 abstract 1
- 125000000383 tetramethylene group Chemical group [H]C([H])([*:1])C([H])([H])C([H])([H])C([H])([H])[*:2] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/655—Somatostatins
- C07K14/6555—Somatostatins at least 1 amino acid in D-form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Endocrinology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19742416048 DE2416048A1 (de) | 1974-04-03 | 1974-04-03 | Neue peptide mit biologischer wirkung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| FR2266516A1 true FR2266516A1 (en) | 1975-10-31 |
Family
ID=5911970
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR7510392A Withdrawn FR2266516A1 (en) | 1974-04-03 | 1975-04-03 | Somatostatin peptide analogues having prolonged activity - inhibit secretion of pituitary growth hormone and glucagon and are used to treat diabetes |
Country Status (8)
| Country | Link |
|---|---|
| JP (1) | JPS50154278A (enrdf_load_stackoverflow) |
| BE (1) | BE827530A (enrdf_load_stackoverflow) |
| DE (1) | DE2416048A1 (enrdf_load_stackoverflow) |
| DK (1) | DK140475A (enrdf_load_stackoverflow) |
| FR (1) | FR2266516A1 (enrdf_load_stackoverflow) |
| LU (1) | LU72178A1 (enrdf_load_stackoverflow) |
| NL (1) | NL7503724A (enrdf_load_stackoverflow) |
| SE (1) | SE7503810L (enrdf_load_stackoverflow) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2313077A1 (fr) * | 1975-06-04 | 1976-12-31 | Ayerst Mckenna & Harrison | Analogues de la somatostatine et leur preparation |
| FR2384745A1 (fr) * | 1976-01-02 | 1978-10-20 | Ayerst Mckenna & Harrison | Derives de la somatostatine et leur preparation |
| EP0002264A1 (en) * | 1977-12-01 | 1979-06-13 | Merck & Co. Inc. | Somatostatin analogs, process for their preparation and pharmaceutical composition thereof |
| EP0002262A1 (en) * | 1977-12-01 | 1979-06-13 | Merck & Co. Inc. | Somatostatin analogs and process for their preparation |
| FR2458539A1 (fr) * | 1979-06-11 | 1981-01-02 | Lilly Co Eli | Peptides apparentes a la somatostatine, leur preparation et leur utilisation therapeutique |
| EP0011366A3 (en) * | 1978-10-02 | 1982-02-10 | Eli Lilly And Company | Synthetic peptides, their preparation, pharmaceutical formulations containing them and intermediates for their preparation |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4118380A (en) * | 1977-07-25 | 1978-10-03 | Ayerst, Mckenna & Harrison Limited | Decapeptide analogs of somatostatin |
| US4244947A (en) * | 1979-08-13 | 1981-01-13 | Ayerst Mckenna And Harrison Inc. | Carba decapeptide derivatives of [TYR6 ]-somatostatin |
| US4485101A (en) * | 1983-10-11 | 1984-11-27 | Administrators Of The Tulane Educational Fund | Peptides |
| US5708135A (en) * | 1995-09-29 | 1998-01-13 | Biomeasure Incorporated | Cyclic peptide analogs of somatostatin |
-
1974
- 1974-04-03 DE DE19742416048 patent/DE2416048A1/de active Pending
-
1975
- 1975-03-27 NL NL7503724A patent/NL7503724A/xx unknown
- 1975-04-01 LU LU72178A patent/LU72178A1/xx unknown
- 1975-04-02 DK DK140475A patent/DK140475A/da not_active Application Discontinuation
- 1975-04-03 JP JP4074775A patent/JPS50154278A/ja active Pending
- 1975-04-03 BE BE155064A patent/BE827530A/xx unknown
- 1975-04-03 SE SE7503810A patent/SE7503810L/ not_active Application Discontinuation
- 1975-04-03 FR FR7510392A patent/FR2266516A1/fr not_active Withdrawn
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2313077A1 (fr) * | 1975-06-04 | 1976-12-31 | Ayerst Mckenna & Harrison | Analogues de la somatostatine et leur preparation |
| FR2384745A1 (fr) * | 1976-01-02 | 1978-10-20 | Ayerst Mckenna & Harrison | Derives de la somatostatine et leur preparation |
| EP0002264A1 (en) * | 1977-12-01 | 1979-06-13 | Merck & Co. Inc. | Somatostatin analogs, process for their preparation and pharmaceutical composition thereof |
| EP0002262A1 (en) * | 1977-12-01 | 1979-06-13 | Merck & Co. Inc. | Somatostatin analogs and process for their preparation |
| EP0011366A3 (en) * | 1978-10-02 | 1982-02-10 | Eli Lilly And Company | Synthetic peptides, their preparation, pharmaceutical formulations containing them and intermediates for their preparation |
| FR2458539A1 (fr) * | 1979-06-11 | 1981-01-02 | Lilly Co Eli | Peptides apparentes a la somatostatine, leur preparation et leur utilisation therapeutique |
Also Published As
| Publication number | Publication date |
|---|---|
| NL7503724A (nl) | 1975-10-07 |
| JPS50154278A (enrdf_load_stackoverflow) | 1975-12-12 |
| DE2416048A1 (de) | 1975-10-30 |
| BE827530A (fr) | 1975-10-03 |
| LU72178A1 (enrdf_load_stackoverflow) | 1977-02-01 |
| DK140475A (enrdf_load_stackoverflow) | 1975-10-04 |
| SE7503810L (sv) | 1975-10-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ST | Notification of lapse |