FR2251333A1 - Water-soluble beta-aescin production - by treating crystalline beta-aescin with bases - Google Patents

Water-soluble beta-aescin production - by treating crystalline beta-aescin with bases

Info

Publication number
FR2251333A1
FR2251333A1 FR7437538A FR7437538A FR2251333A1 FR 2251333 A1 FR2251333 A1 FR 2251333A1 FR 7437538 A FR7437538 A FR 7437538A FR 7437538 A FR7437538 A FR 7437538A FR 2251333 A1 FR2251333 A1 FR 2251333A1
Authority
FR
France
Prior art keywords
pref
aescin
beta
water
drying
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7437538A
Other languages
French (fr)
Other versions
FR2251333B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Patent GmbH
Original Assignee
Merck Patent GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent GmbH filed Critical Merck Patent GmbH
Publication of FR2251333A1 publication Critical patent/FR2251333A1/en
Application granted granted Critical
Publication of FR2251333B1 publication Critical patent/FR2251333B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/256—Polyterpene radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Micelle-colloidl, water-soluble beta-aescin is produced by dissolving beta-aescin in an aqueous inorganic base (pref. alkali or ammonium hydroxide), opt. with the addition of an organic solvent which is at least partially water-soluble (pref. an alcohol); removing any organic solvent which has been added; removing the inorganic base from the resulting aqueous solution (pref. by means of a cation-exchanger), advantageously after adjustment of the solution to pH 4.5-6.5 by addition of acid; and subjecting the resulting solution to spray-drying or freeze-drying. All process steps except spray-drying are pref. carried out at 45 degrees C. Micelle-colloidal, beta-aescin having a water-solubility of not 8 wt. % (pref. is not 12 wt. %) are claimed as new products. Simple procedure enabling beta-aescin with a water-solubility of >15% or even >20% to be produced. Pref. aqueous bases for dissolving the crystalline beta aescinare Na2CO3, K2CO3, NaHCO3, KHCO3, Na2HPO4, K2HPO4, Na3PO4, sodium acetate and potassium acetate, and the corresponding ammonium salts. The concentration of the base is not critical, but is pref. 0.5- to 2.5-N; the pH is generally 7.3-12.5, pref. 7.5-10.5. The addition of water-miscible organic solvent is particularly advantageous when ammonia or a basically reacting salt is used as the base. After removal of any organic solvent, the base is pref. removed by treating with an acidic cation exchange resin. The water-soluble beta-aescin is subsequently isolated by standard spray drying or freeze-drying procedures.
FR7437538A 1973-11-16 1974-11-14 Water-soluble beta-aescin production - by treating crystalline beta-aescin with bases Granted FR2251333A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19732357226 DE2357226A1 (en) 1973-11-16 1973-11-16 METHOD FOR PRODUCING WATER-SOLUBLE BETA-AESCIN

Publications (2)

Publication Number Publication Date
FR2251333A1 true FR2251333A1 (en) 1975-06-13
FR2251333B1 FR2251333B1 (en) 1978-07-21

Family

ID=5898269

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7437538A Granted FR2251333A1 (en) 1973-11-16 1974-11-14 Water-soluble beta-aescin production - by treating crystalline beta-aescin with bases

Country Status (2)

Country Link
DE (1) DE2357226A1 (en)
FR (1) FR2251333A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2530953C2 (en) * 1975-07-11 1994-07-07 Dr. Madaus & Co, 5000 Köln Process for the production of X-ray amorphous aescin, X-ray amorphous aescin obtainable by this process and medicament containing it

Also Published As

Publication number Publication date
DE2357226A1 (en) 1975-05-28
FR2251333B1 (en) 1978-07-21

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Legal Events

Date Code Title Description
ST Notification of lapse