FR2248031A1 - 5-oxo dibenzo(a,d)cycloheptene derivs - with analgesic, antipyretic and anti-inflamm- atory activity - Google Patents
5-oxo dibenzo(a,d)cycloheptene derivs - with analgesic, antipyretic and anti-inflamm- atory activityInfo
- Publication number
- FR2248031A1 FR2248031A1 FR7337404A FR7337404A FR2248031A1 FR 2248031 A1 FR2248031 A1 FR 2248031A1 FR 7337404 A FR7337404 A FR 7337404A FR 7337404 A FR7337404 A FR 7337404A FR 2248031 A1 FR2248031 A1 FR 2248031A1
- Authority
- FR
- France
- Prior art keywords
- derivs
- inflamm
- cycloheptene
- antipyretic
- analgesic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
- C07D317/22—Radicals substituted by singly bound oxygen or sulfur atoms etherified
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/76—Unsaturated compounds containing keto groups
- C07C59/86—Unsaturated compounds containing keto groups containing six-membered aromatic rings and other rings
Abstract
Novel cpds. of formula (I): (where X is H, halogen, 1-4C alkyl(thio) or alkoxy or CF3; R1 and R2 are H or 1-4C alkyl; R3 is OH, 1-4C alkoxy, 2,2-dimethyl-1,3-dioxolan-4-ylmethoxy or NR4R5; R4 and R5 are H, 1-4C (hydroxy)alkyl or Ph or NR4R5 is a 5- or 6-membered heterocycle opt. contg. a 2nd heteroatom selected from O S and NR; and R is H or 1-4C alkyl) are prepd. by (a) cyclisn and partial hydrolysis of a cpd. (II): (where Y is OH or Cl) to give (I; R3=NH2); (b) hydrolysis of (I; R3=NH2) or the corresp. nitrile to give (I; R3=OH); or (c) reacting R3H with the corresp. acid halide to form other esters and amides (I).
Priority Applications (25)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7337404A FR2248031A1 (en) | 1973-10-19 | 1973-10-19 | 5-oxo dibenzo(a,d)cycloheptene derivs - with analgesic, antipyretic and anti-inflamm- atory activity |
OA55125A OA04603A (en) | 1973-03-02 | 1974-02-20 | New derivatives of dibenzo [a, d] cycloheptene, their salts and their preparation. |
NL7402475A NL7402475A (en) | 1973-03-02 | 1974-02-22 | |
GB915474A GB1412095A (en) | 1973-03-02 | 1974-02-28 | Dibenzo a,d cycloheptene derivatives |
US05/447,059 US3933905A (en) | 1973-03-02 | 1974-02-28 | (5-Oxo-10,11-dihydrodibenzo[a,d]-cyclohepten-2-yl)-alkanoic acids |
IL44311A IL44311A (en) | 1973-03-02 | 1974-02-28 | Alpha-(5-oxo-10,11-dihydrodibenzo (a,d) cyclohepten-2-yl)-alkanoic acid derivatives processes for their preparation and pharmaceutical compositions containing them |
AU66142/74A AU480735B2 (en) | 1973-03-02 | 1974-02-28 | DIBENZO [a,d] CYCLOHEPTENE DERIVATIVES |
CS149174A CS187336B2 (en) | 1973-10-19 | 1974-02-28 | Method of producing novel derivatives of dibenzo/a,d/cycloheptane |
CA193,752A CA1022929A (en) | 1973-03-02 | 1974-02-28 | Dibenzo (a,d) cycloheptene derivatives; their preparation and compositions |
IE00421/74A IE38942B1 (en) | 1973-03-02 | 1974-02-28 | Dibenzo/a,d/cycloheptene derivatives |
JP49022905A JPS5024260A (en) | 1973-03-02 | 1974-02-28 | |
NO740723A NO139783C (en) | 1973-10-19 | 1974-03-01 | ANALOGICAL PROCEDURE FOR PREPARATION OF NEW DIBENZO DERIVATIVES (A, D) CYCLOHEPTEN |
SU742006372A SU614744A3 (en) | 1973-10-19 | 1974-03-01 | Method of obtaining dibenzo(a,d)cycloheptene derivatives |
LU69524A LU69524A1 (en) | 1973-03-02 | 1974-03-01 | |
HURO000771 HU167664B (en) | 1973-10-19 | 1974-03-01 | Process for producing new dibenzo-/a,d/cycloheptenyl-2-carboxylic acid derivatives |
SE7402779A SE397972B (en) | 1973-03-02 | 1974-03-01 | PROCEDURE FOR PREPARING NEW DERIVATIVES OF DIBENSO / A, D / CYCLOHEPTEN-5-ON |
AT168974A AT332370B (en) | 1973-10-19 | 1974-03-01 | PROCESS FOR THE PREPARATION OF NEW 10,11-DIHYDRO-5-OXODIBENZO (A, D) CYCLOHEPTEN-2-YLALCANIC ACID AMIDES |
FI614/74A FI58115C (en) | 1973-03-02 | 1974-03-01 | FOERFARANDE FOER FRAMSTAELLNING AV NYA THERAPEUTIC ACID ACTIVE 5-OXODIBENSOCYCLOHEPTADIENYL ETHYRADERIVAT |
AR252579A AR202811A1 (en) | 1973-03-02 | 1974-03-01 | PROCEDURE FOR THE PREPARATION OF (OXO-5-DIHIDRO-10,11-DIBENZO <A, D> CYCLOHEPTENIL-2) -2 PROPANOILAMIDE, AND ITS SALTS |
CH297174A CH589043A5 (en) | 1973-10-19 | 1974-03-01 | |
DK110874A DK140721B (en) | 1973-10-19 | 1974-03-01 | Analogous process for the preparation of dibenzo (a, d) cycloheptenecarboxylic acid derivatives or acid addition salts thereof. |
DE2409919A DE2409919A1 (en) | 1973-03-02 | 1974-03-01 | NEW DIBENZO SQUARE BRACKET ON A, SQUARE BRACKET FOR CYCLOHEPTEN DERIVATIVES, THEIR PRODUCTION AND COMPOSITIONS THEREOF |
PL16923874A PL90912B1 (en) | 1973-10-19 | 1974-03-02 | |
ES423846A ES423846A1 (en) | 1973-10-19 | 1974-03-02 | Procedure for preparing derivatives of dibenzo (a, d) ciclohepteno. (Machine-translation by Google Translate, not legally binding) |
US05/556,389 US3975437A (en) | 1973-03-02 | 1975-03-07 | Dibenzo (a,d) cycloheptene derivatives |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7337404A FR2248031A1 (en) | 1973-10-19 | 1973-10-19 | 5-oxo dibenzo(a,d)cycloheptene derivs - with analgesic, antipyretic and anti-inflamm- atory activity |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2248031A1 true FR2248031A1 (en) | 1975-05-16 |
FR2248031B1 FR2248031B1 (en) | 1977-03-11 |
Family
ID=9126690
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR7337404A Granted FR2248031A1 (en) | 1973-03-02 | 1973-10-19 | 5-oxo dibenzo(a,d)cycloheptene derivs - with analgesic, antipyretic and anti-inflamm- atory activity |
Country Status (8)
Country | Link |
---|---|
AT (1) | AT332370B (en) |
CH (1) | CH589043A5 (en) |
CS (1) | CS187336B2 (en) |
ES (1) | ES423846A1 (en) |
FR (1) | FR2248031A1 (en) |
HU (1) | HU167664B (en) |
PL (1) | PL90912B1 (en) |
SU (1) | SU614744A3 (en) |
-
1973
- 1973-10-19 FR FR7337404A patent/FR2248031A1/en active Granted
-
1974
- 1974-02-28 CS CS149174A patent/CS187336B2/en unknown
- 1974-03-01 HU HURO000771 patent/HU167664B/en unknown
- 1974-03-01 CH CH297174A patent/CH589043A5/xx not_active IP Right Cessation
- 1974-03-01 SU SU742006372A patent/SU614744A3/en active
- 1974-03-01 AT AT168974A patent/AT332370B/en not_active IP Right Cessation
- 1974-03-02 ES ES423846A patent/ES423846A1/en not_active Expired
- 1974-03-02 PL PL16923874A patent/PL90912B1/pl unknown
Also Published As
Publication number | Publication date |
---|---|
SU614744A3 (en) | 1978-07-05 |
PL90912B1 (en) | 1977-02-28 |
FR2248031B1 (en) | 1977-03-11 |
AT332370B (en) | 1976-09-27 |
CS187336B2 (en) | 1979-01-31 |
ATA168974A (en) | 1976-01-15 |
ES423846A1 (en) | 1976-05-16 |
CH589043A5 (en) | 1977-06-30 |
HU167664B (en) | 1975-11-28 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
ST | Notification of lapse |