FR2240015A1 - - Google Patents

Info

Publication number
FR2240015A1
FR2240015A1 FR7426815A FR7426815A FR2240015A1 FR 2240015 A1 FR2240015 A1 FR 2240015A1 FR 7426815 A FR7426815 A FR 7426815A FR 7426815 A FR7426815 A FR 7426815A FR 2240015 A1 FR2240015 A1 FR 2240015A1
Authority
FR
France
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7426815A
Other languages
French (fr)
Other versions
FR2240015B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Scherico Ltd
Original Assignee
Scherico Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/452,586 external-priority patent/US4029882A/en
Application filed by Scherico Ltd filed Critical Scherico Ltd
Publication of FR2240015A1 publication Critical patent/FR2240015A1/fr
Application granted granted Critical
Publication of FR2240015B1 publication Critical patent/FR2240015B1/fr
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
    • C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
    • C07H15/234—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
    • C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
    • C07H15/234—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2
    • C07H15/236—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2 a saccharide radical being substituted by an alkylamino radical in position 3 and by two substituents different from hydrogen in position 4, e.g. gentamicin complex, sisomicin, verdamycin
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
FR7426815A 1973-08-06 1974-08-01 Expired FR2240015B1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US38575173A 1973-08-06 1973-08-06
US45260074A 1974-03-19 1974-03-19
US05/452,586 US4029882A (en) 1974-03-19 1974-03-19 Selective acylation of the C-1 amino group of aminoglycoside antibiotics

Publications (2)

Publication Number Publication Date
FR2240015A1 true FR2240015A1 (en) 1975-03-07
FR2240015B1 FR2240015B1 (en) 1978-08-18

Family

ID=27409729

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7426815A Expired FR2240015B1 (en) 1973-08-06 1974-08-01

Country Status (20)

Country Link
AR (1) AR215834A1 (en)
BE (1) BE818431A (en)
BG (1) BG25804A3 (en)
CH (1) CH606076A5 (en)
CY (1) CY1018A (en)
DD (1) DD119037A5 (en)
DE (2) DE2462485C2 (en)
DK (1) DK146298C (en)
FI (1) FI62100C (en)
FR (1) FR2240015B1 (en)
GB (1) GB1473733A (en)
HK (1) HK55179A (en)
IE (1) IE40437B1 (en)
IL (1) IL45385A (en)
KE (1) KE2981A (en)
LU (1) LU70661A1 (en)
MY (1) MY8000090A (en)
NL (1) NL171587C (en)
NO (1) NO139483C (en)
SE (1) SE424994B (en)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2289202A1 (en) * 1974-10-26 1976-05-28 Pfizer NEW AMINOGLYCOSIDES OF 2-DEOXYSTREPTAMINE, THEIR PREPARATION AND ANTIBACTERIAL COMPOSITION CONTAINING THEM
EP0000057A1 (en) * 1977-06-10 1978-12-20 Bayer Ag Selectively protected 4,6-di-O-(aminoglycosyl)-1,3-diamino-cyclitols
EP0000800A1 (en) * 1977-08-05 1979-02-21 Technobiotic Ltd. Selective N-protection of aminoglycosides and novel, selectively protected aminoglycoside intermediates
FR2405266A1 (en) * 1975-09-08 1979-05-04 Scherico Ltd Antibacterial desoxystreptamines - esp 5-epi-4,6-di-(aminoglycosyl)-2-desoxystreptamines and 5-epi-(amino or azido)-5-desoxy derivs
EP0002835A1 (en) * 1977-12-29 1979-07-11 Shionogi & Co., Ltd. Aminoglycoside derivatives, process for their manufacture and pharmaceutical compositions
EP0009201A1 (en) * 1978-09-20 1980-04-02 Bayer Ag Selectively protected 4,6-di-O-(aminoglycosyl)-1,3-diaminocyclitols, method for their preparation and their use as intermediates
EP0009670A1 (en) * 1978-09-11 1980-04-16 Shionogi & Co., Ltd. Aminoglycoside derivatives, process for their preparation and pharmaceutical compositions
EP0022504A1 (en) * 1979-07-12 1981-01-21 Bayer Ag 1-N-alkylsisomicin derivatives, process for their preparation and their use as medicines

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4217446A (en) 1974-10-26 1980-08-12 Pfizer Inc. ωAmino-2-hydroxyalkyl derivatives of aminoglycoside antibiotics
CN1040177C (en) * 1993-04-23 1998-10-14 江苏省微生物研究所 1-N-ethyl gentamicin derivative and its preparing method
AU2008326297B2 (en) 2007-11-21 2012-11-08 Cipla USA, Inc. Antibacterial aminoglycoside analogs
WO2010132765A2 (en) 2009-05-15 2010-11-18 Achaogen, Inc. Antibacterial aminoglycoside analogs
WO2010132759A1 (en) 2009-05-15 2010-11-18 Achaogen, Inc. Antibacterial derivatives of dibekacin
WO2010132768A1 (en) 2009-05-15 2010-11-18 Achaogen, Inc. Antibacterial derivatives of sisomicin
WO2010132760A1 (en) 2009-05-15 2010-11-18 Achaogen, Inc. Antibacterial derivatives of tobramycin
WO2010132757A2 (en) 2009-05-15 2010-11-18 Achaogen, Inc. Antibacterial aminoglycoside analogs
CN101575311B (en) * 2009-06-19 2011-05-04 无锡好芳德药业有限公司 Method for preparing epiphysin

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1235311B (en) 1963-03-25 1967-03-02 Roussel Uclaf Process for the production of N-monophenylaethylneomycin B or its therapeutically acceptable salts

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2289202A1 (en) * 1974-10-26 1976-05-28 Pfizer NEW AMINOGLYCOSIDES OF 2-DEOXYSTREPTAMINE, THEIR PREPARATION AND ANTIBACTERIAL COMPOSITION CONTAINING THEM
FR2405266A1 (en) * 1975-09-08 1979-05-04 Scherico Ltd Antibacterial desoxystreptamines - esp 5-epi-4,6-di-(aminoglycosyl)-2-desoxystreptamines and 5-epi-(amino or azido)-5-desoxy derivs
EP0000057A1 (en) * 1977-06-10 1978-12-20 Bayer Ag Selectively protected 4,6-di-O-(aminoglycosyl)-1,3-diamino-cyclitols
EP0000800A1 (en) * 1977-08-05 1979-02-21 Technobiotic Ltd. Selective N-protection of aminoglycosides and novel, selectively protected aminoglycoside intermediates
EP0002835A1 (en) * 1977-12-29 1979-07-11 Shionogi & Co., Ltd. Aminoglycoside derivatives, process for their manufacture and pharmaceutical compositions
EP0009670A1 (en) * 1978-09-11 1980-04-16 Shionogi & Co., Ltd. Aminoglycoside derivatives, process for their preparation and pharmaceutical compositions
EP0009201A1 (en) * 1978-09-20 1980-04-02 Bayer Ag Selectively protected 4,6-di-O-(aminoglycosyl)-1,3-diaminocyclitols, method for their preparation and their use as intermediates
EP0022504A1 (en) * 1979-07-12 1981-01-21 Bayer Ag 1-N-alkylsisomicin derivatives, process for their preparation and their use as medicines
US4335114A (en) * 1979-07-12 1982-06-15 Bayer Aktiengesellschaft 1-N-Alkylsisomicin derivatives, their production and their medicinal use

Also Published As

Publication number Publication date
IL45385A (en) 1978-10-31
IE40437B1 (en) 1979-06-06
FI62100B (en) 1982-07-30
NO139483C (en) 1979-03-21
NO139483B (en) 1978-12-11
BE818431A (en) 1975-02-03
DK146298C (en) 1984-02-06
NL7410363A (en) 1975-02-10
DE2437160A1 (en) 1975-02-20
LU70661A1 (en) 1975-05-21
BG25804A3 (en) 1978-12-12
DE2462485A1 (en) 1977-04-21
CY1018A (en) 1979-11-23
DE2437160B2 (en) 1979-01-04
FR2240015B1 (en) 1978-08-18
GB1473733A (en) 1977-05-18
DD119037A5 (en) 1976-04-05
CH606076A5 (en) 1978-10-13
AR215834A1 (en) 1979-11-15
NL171587B (en) 1982-11-16
DE2462485C2 (en) 1987-04-09
IL45385A0 (en) 1974-11-29
AU7194274A (en) 1976-02-05
DK146298B (en) 1983-08-29
NL171587C (en) 1983-04-18
SE7409946L (en) 1975-02-07
KE2981A (en) 1979-07-20
HK55179A (en) 1979-08-17
MY8000090A (en) 1980-12-31
SE424994B (en) 1982-08-23
IE40437L (en) 1975-02-06
DE2437160C3 (en) 1979-08-30
FI62100C (en) 1982-11-10
FI230474A (en) 1975-02-07
NO742787L (en) 1975-03-03
DK412474A (en) 1975-04-01

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Legal Events

Date Code Title Description
CD Change of name or company name
CC Supplementary protection certificate (spc) laid open to the public (law of 25 june 1990)

Free format text: 92C0255, 920521

CB Supplementary protection certificate (spc) granted (law of 25 june 1990)

Free format text: 92C0255, 740801

CL Concession to grant licences