FR2219159A1 - Adamantane nitroxide radicals - antiviral and anticancer agents, also useful in nuclear resonance magnetometry - Google Patents

Adamantane nitroxide radicals - antiviral and anticancer agents, also useful in nuclear resonance magnetometry

Info

Publication number
FR2219159A1
FR2219159A1 FR7306623A FR7306623A FR2219159A1 FR 2219159 A1 FR2219159 A1 FR 2219159A1 FR 7306623 A FR7306623 A FR 7306623A FR 7306623 A FR7306623 A FR 7306623A FR 2219159 A1 FR2219159 A1 FR 2219159A1
Authority
FR
France
Prior art keywords
adamantane
antiviral
useful
anticancer agents
nuclear resonance
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7306623A
Other languages
French (fr)
Other versions
FR2219159B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Commissariat a lEnergie Atomique et aux Energies Alternatives CEA
Original Assignee
Commissariat a lEnergie Atomique CEA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Commissariat a lEnergie Atomique CEA filed Critical Commissariat a lEnergie Atomique CEA
Priority to FR7306623A priority Critical patent/FR2219159A1/en
Publication of FR2219159A1 publication Critical patent/FR2219159A1/en
Application granted granted Critical
Publication of FR2219159B1 publication Critical patent/FR2219159B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22—Bridged ring systems

Abstract

Title radicals are of formula (I): (where R1-R12 = H or organic radicals). These radicals are prepd. from N-benzyl nor-pseudopelletierine by conversion into the tosyl hydrazone, then into 9-benzyl-9-aza nor -adamantane, followed by hydrogenation to eliminate the benzyl gp. and oxidn.
FR7306623A 1973-02-23 1973-02-23 Adamantane nitroxide radicals - antiviral and anticancer agents, also useful in nuclear resonance magnetometry Granted FR2219159A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR7306623A FR2219159A1 (en) 1973-02-23 1973-02-23 Adamantane nitroxide radicals - antiviral and anticancer agents, also useful in nuclear resonance magnetometry

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7306623A FR2219159A1 (en) 1973-02-23 1973-02-23 Adamantane nitroxide radicals - antiviral and anticancer agents, also useful in nuclear resonance magnetometry

Publications (2)

Publication Number Publication Date
FR2219159A1 true FR2219159A1 (en) 1974-09-20
FR2219159B1 FR2219159B1 (en) 1976-11-05

Family

ID=9115355

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7306623A Granted FR2219159A1 (en) 1973-02-23 1973-02-23 Adamantane nitroxide radicals - antiviral and anticancer agents, also useful in nuclear resonance magnetometry

Country Status (1)

Country Link
FR (1) FR2219159A1 (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1389181A2 (en) * 2001-04-02 2004-02-18 Panorama Research, Inc. Antioxidant nitroxides and nitrones as therapeutic agents
WO2012008228A1 (en) * 2010-07-16 2012-01-19 第一三共株式会社 Method for oxidizing alcohols
CN106366082A (en) * 2016-08-22 2017-02-01 深圳市宏辉浩医药科技有限公司 Preparation method of 2-azanoradamantane-N-Oxyl

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7619007B2 (en) 2004-11-23 2009-11-17 Adamas Pharmaceuticals, Inc. Method and composition for administering an NMDA receptor antagonist to a subject
KR101406456B1 (en) 2005-04-06 2014-06-20 아다마스 파마슈티칼스, 인코포레이티드 Methods and compositions for treatment of cns disorders

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
NEANT *

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1389181A2 (en) * 2001-04-02 2004-02-18 Panorama Research, Inc. Antioxidant nitroxides and nitrones as therapeutic agents
EP1389181A4 (en) * 2001-04-02 2005-10-19 Panorama Res Inc Antioxidant nitroxides and nitrones as therapeutic agents
WO2012008228A1 (en) * 2010-07-16 2012-01-19 第一三共株式会社 Method for oxidizing alcohols
JPWO2012008228A1 (en) * 2010-07-16 2013-09-05 第一三共株式会社 Method for oxidizing alcohols
US8871981B2 (en) 2010-07-16 2014-10-28 Tohoku University Method for oxidizing alcohols
EP2594550A4 (en) * 2010-07-16 2015-06-10 Univ Tohoku Method for oxidizing alcohols
JP5763638B2 (en) * 2010-07-16 2015-08-12 第一三共株式会社 Method for oxidizing alcohols
CN106366082A (en) * 2016-08-22 2017-02-01 深圳市宏辉浩医药科技有限公司 Preparation method of 2-azanoradamantane-N-Oxyl

Also Published As

Publication number Publication date
FR2219159B1 (en) 1976-11-05

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Legal Events

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