FR21C1018I2 - SOLID DISPERSION OF AMORPHOUS FORM OF (R)-1(2,2-DIFLUOROBENZO(D)(1,3)DIOXOL-5-YL)-N-(1-(2,3-DIHYDROXYPROPYL)-6-FLUORO- 2-(1-HYDROXY-2-METHYLPROPANE-2-YL)-1H-INDOL-5-YL)-CYCLOPROPANECARBOXAMIDE - Google Patents

SOLID DISPERSION OF AMORPHOUS FORM OF (R)-1(2,2-DIFLUOROBENZO(D)(1,3)DIOXOL-5-YL)-N-(1-(2,3-DIHYDROXYPROPYL)-6-FLUORO- 2-(1-HYDROXY-2-METHYLPROPANE-2-YL)-1H-INDOL-5-YL)-CYCLOPROPANECARBOXAMIDE

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Publication number
FR21C1018I2
FR21C1018I2 FR21C1018C FR21C1018C FR21C1018I2 FR 21C1018 I2 FR21C1018 I2 FR 21C1018I2 FR 21C1018 C FR21C1018 C FR 21C1018C FR 21C1018 C FR21C1018 C FR 21C1018C FR 21C1018 I2 FR21C1018 I2 FR 21C1018I2
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FR
France
Prior art keywords
difluorobenzo
cyclopropanecarboxamide
dioxol
dihydroxypropyl
methylpropane
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
FR21C1018C
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French (fr)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vertex Pharmaceuticals Inc
Original Assignee
Vertex Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharmaceuticals Inc filed Critical Vertex Pharmaceuticals Inc
Publication of FR21C1018I1 publication Critical patent/FR21C1018I1/en
Application granted granted Critical
Publication of FR21C1018I2 publication Critical patent/FR21C1018I2/en
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    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
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    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
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FR21C1018C 2010-03-25 2021-05-14 SOLID DISPERSION OF AMORPHOUS FORM OF (R)-1(2,2-DIFLUOROBENZO(D)(1,3)DIOXOL-5-YL)-N-(1-(2,3-DIHYDROXYPROPYL)-6-FLUORO- 2-(1-HYDROXY-2-METHYLPROPANE-2-YL)-1H-INDOL-5-YL)-CYCLOPROPANECARBOXAMIDE Active FR21C1018I2 (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US31737610P 2010-03-25 2010-03-25
US31995310P 2010-04-01 2010-04-01
US32156110P 2010-04-07 2010-04-07
US32163610P 2010-04-07 2010-04-07
PCT/US2011/030032 WO2011119984A1 (en) 2010-03-25 2011-03-25 Solid forms of (r)-1(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-n-(1-(2,3-dihyderoxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1h-indol-5-yl) cyclopropanecarboxamide
EP11713134.2A EP2563778B1 (en) 2010-03-25 2011-03-25 Crystalline form of (r)-1(2,2 -difluorobenzo[d][1,3]dioxol-5yl)-n-(1-(2,3-dihyderoxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2yl)-1h-indol-5yl)cyclopropanecarboxamide

Publications (2)

Publication Number Publication Date
FR21C1018I1 FR21C1018I1 (en) 2021-07-02
FR21C1018I2 true FR21C1018I2 (en) 2023-02-17

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FR21C1018C Active FR21C1018I2 (en) 2010-03-25 2021-05-14 SOLID DISPERSION OF AMORPHOUS FORM OF (R)-1(2,2-DIFLUOROBENZO(D)(1,3)DIOXOL-5-YL)-N-(1-(2,3-DIHYDROXYPROPYL)-6-FLUORO- 2-(1-HYDROXY-2-METHYLPROPANE-2-YL)-1H-INDOL-5-YL)-CYCLOPROPANECARBOXAMIDE

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