FR2196154A2 - N-(amidino alkyl)-n-acyl-amines - as analgesics and antiinflammatory agents - Google Patents

N-(amidino alkyl)-n-acyl-amines - as analgesics and antiinflammatory agents

Info

Publication number
FR2196154A2
FR2196154A2 FR7229836A FR7229836A FR2196154A2 FR 2196154 A2 FR2196154 A2 FR 2196154A2 FR 7229836 A FR7229836 A FR 7229836A FR 7229836 A FR7229836 A FR 7229836A FR 2196154 A2 FR2196154 A2 FR 2196154A2
Authority
FR
France
Prior art keywords
alkyl
amidino
analgesics
acyl
amines
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7229836A
Other languages
French (fr)
Other versions
FR2196154B2 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cephalon France SAS
Original Assignee
Laboratoire L Lafon SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to BE789305D priority Critical patent/BE789305A/en
Application filed by Laboratoire L Lafon SA filed Critical Laboratoire L Lafon SA
Priority to FR7229836A priority patent/FR2196154A2/en
Priority to GB4471472A priority patent/GB1403201A/en
Publication of FR2196154A2 publication Critical patent/FR2196154A2/en
Application granted granted Critical
Publication of FR2196154B2 publication Critical patent/FR2196154B2/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
    • C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
    • C07C257/14—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/12—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. N-hydroxyamidines
    • C07C259/14—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. N-hydroxyamidines having carbon atoms of hydroxamidine groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/20—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D233/24—Radicals substituted by nitrogen atoms not forming part of a nitro radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Cpds. (I) and their salts. A-N(COR)-(CH2)n-B (I) (where A is Ph or cyclohexyl, R is 1-5C alkyl, phenyl or benzyl opt. halosubstd. n is 1,2 or 3, B is COORo or Ro is H, alkyl, ammonium or M1/x ; M is a metal of valency x, R3 is H, OH, 1-3C alkyl; R2 is H, OH, or 1-3C alkyl; R1 is H, R1 and R2 together with the two amidino-N atoms, is 2-DELTA2-imidazolinyl or 2 (1,4,5,6-tetrahydropyrimidyl), R3 in this case being H) are prepd. from the A-NH(CH2)nCN by acyln., then formation of the iminoether, followed by treatment with R2R3N and finally optionally treatment with NH2OH or an alkylene diamine. Thus (I,A = Ph, R= Et, n = Z and B is amidino) is prepd. by acylating beta-anilino propionitrile with (PrO)2O then reaction with EtOH, and NH3.
FR7229836A 1971-09-28 1972-08-21 N-(amidino alkyl)-n-acyl-amines - as analgesics and antiinflammatory agents Granted FR2196154A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
BE789305D BE789305A (en) 1971-09-28 NEW ANTALGIC COMPOUNDS
FR7229836A FR2196154A2 (en) 1972-08-21 1972-08-21 N-(amidino alkyl)-n-acyl-amines - as analgesics and antiinflammatory agents
GB4471472A GB1403201A (en) 1971-09-28 1972-09-27 N,n-disubstituted amides their preparation and pharmaceutical compositions containing them

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7229836A FR2196154A2 (en) 1972-08-21 1972-08-21 N-(amidino alkyl)-n-acyl-amines - as analgesics and antiinflammatory agents

Publications (2)

Publication Number Publication Date
FR2196154A2 true FR2196154A2 (en) 1974-03-15
FR2196154B2 FR2196154B2 (en) 1975-10-17

Family

ID=9103403

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7229836A Granted FR2196154A2 (en) 1971-09-28 1972-08-21 N-(amidino alkyl)-n-acyl-amines - as analgesics and antiinflammatory agents

Country Status (1)

Country Link
FR (1) FR2196154A2 (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2116588A1 (en) * 1969-09-24 1972-07-13 Malesci Sas

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2116588A1 (en) * 1969-09-24 1972-07-13 Malesci Sas

Also Published As

Publication number Publication date
FR2196154B2 (en) 1975-10-17

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