FR2131894A2 - 4-naphthoxy-3-hydroxy-butyramidines as beta-blocking agents - Google Patents

4-naphthoxy-3-hydroxy-butyramidines as beta-blocking agents

Info

Publication number
FR2131894A2
FR2131894A2 FR7111548A FR7111548A FR2131894A2 FR 2131894 A2 FR2131894 A2 FR 2131894A2 FR 7111548 A FR7111548 A FR 7111548A FR 7111548 A FR7111548 A FR 7111548A FR 2131894 A2 FR2131894 A2 FR 2131894A2
Authority
FR
France
Prior art keywords
beta
butyramidines
naphthoxy
hydroxy
blocking agents
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7111548A
Other languages
French (fr)
Other versions
FR2131894B2 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to FR7111548A priority Critical patent/FR2131894A2/en
Priority to CH735971A priority patent/CH524575A/en
Priority to BE767721A priority patent/BE767721A/en
Priority to GB1755871A priority patent/GB1298525A/en
Priority to NL7107882A priority patent/NL169177C/en
Priority to CA116379A priority patent/CA927385A/en
Priority to LU63418D priority patent/LU63418A1/xx
Priority to DE19712166869 priority patent/DE2166869C3/en
Priority to DE19712132113 priority patent/DE2132113C3/en
Priority to SE829771A priority patent/SE381870B/en
Priority to JP4691971A priority patent/JPS517662B1/ja
Publication of FR2131894A2 publication Critical patent/FR2131894A2/en
Application granted granted Critical
Publication of FR2131894B2 publication Critical patent/FR2131894B2/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
    • C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
    • C07D303/22—Ethers with hydroxy compounds containing no oxirane rings with monohydroxy compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/12—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. N-hydroxyamidines
    • C07C259/14—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. N-hydroxyamidines having carbon atoms of hydroxamidine groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/20—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D233/22—Radicals substituted by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Title cpds (I) and their salts where A is alpha- or beta-naphthyl; R3 is H or 1-3C alkyl; R2 is H or OH or 1-3C alkyl; and R1 is H or C(:NR1)NR2 is 2-imidazolidinyl or 2-(1,4,5,6-tetrahydropyrimidinyl) and R3 is H are prepd from the butyronitrile by formation of the iminoethe then reaction with HNR2R3. (I, R1=R2=R3=H) with NH2OH or a diamine gives the amino oxime or cyclic amidine. Medicaments are in forms for oral, rectal or perenteral administration.
FR7111548A 1970-06-29 1971-04-01 4-naphthoxy-3-hydroxy-butyramidines as beta-blocking agents Granted FR2131894A2 (en)

Priority Applications (11)

Application Number Priority Date Filing Date Title
FR7111548A FR2131894A2 (en) 1971-04-01 1971-04-01 4-naphthoxy-3-hydroxy-butyramidines as beta-blocking agents
CH735971A CH524575A (en) 1970-06-29 1971-05-19 Process for the preparation of naphthyloxy-butyramidines
BE767721A BE767721A (en) 1970-06-29 1971-05-27 BUTYRAMIDINS
GB1755871A GB1298525A (en) 1970-06-29 1971-05-27 Improvements in or relating to butyramidine compositions
NL7107882A NL169177C (en) 1970-06-29 1971-06-09 METHOD FOR PREPARING OR MANUFACTURING A MEDICINAL PRODUCT, ACTING ON THE CARDIOVASCULAR SYSTEM, AND METHOD FOR PREPARING MEDICINAL ARYLALKYLAMIDINE DERIVATIVES THEREFOR.
CA116379A CA927385A (en) 1970-06-29 1971-06-23 Butyramidine
LU63418D LU63418A1 (en) 1970-06-29 1971-06-25
DE19712166869 DE2166869C3 (en) 1970-06-29 1971-06-28 4-a-Naphthoxy-3-hydroxy-butyramidoxime, process for its preparation and pharmaceutical compositions containing it
DE19712132113 DE2132113C3 (en) 1970-06-29 1971-06-28 Derivatives and analogs of naphthoxybutyramidine and their addition salts with acids, their preparation and pharmaceutical compositions containing them
SE829771A SE381870B (en) 1970-06-29 1971-06-28 PROCEDURE FOR THE PREPARATION OF CERTAIN STATEMENTS THERAPEUTICALLY APPLICABLE BUTYRAMIDINES
JP4691971A JPS517662B1 (en) 1970-06-29 1971-06-29

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7111548A FR2131894A2 (en) 1971-04-01 1971-04-01 4-naphthoxy-3-hydroxy-butyramidines as beta-blocking agents

Publications (2)

Publication Number Publication Date
FR2131894A2 true FR2131894A2 (en) 1972-11-17
FR2131894B2 FR2131894B2 (en) 1974-08-02

Family

ID=9074593

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7111548A Granted FR2131894A2 (en) 1970-06-29 1971-04-01 4-naphthoxy-3-hydroxy-butyramidines as beta-blocking agents

Country Status (1)

Country Link
FR (1) FR2131894A2 (en)

Also Published As

Publication number Publication date
FR2131894B2 (en) 1974-08-02

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