FR2182699A2 - Semi-synthetic penicillins prepn - by enzymatic hydrolysis using escherichia-a coli or aerobacter aerogenes - Google Patents

Semi-synthetic penicillins prepn - by enzymatic hydrolysis using escherichia-a coli or aerobacter aerogenes

Info

Publication number
FR2182699A2
FR2182699A2 FR7215891A FR7215891A FR2182699A2 FR 2182699 A2 FR2182699 A2 FR 2182699A2 FR 7215891 A FR7215891 A FR 7215891A FR 7215891 A FR7215891 A FR 7215891A FR 2182699 A2 FR2182699 A2 FR 2182699A2
Authority
FR
France
Prior art keywords
escherichia
prepn
coli
semi
aerobacter aerogenes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
FR7215891A
Other languages
French (fr)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alfa Farmaceutici SpA
Original Assignee
Alfa Farmaceutici SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alfa Farmaceutici SpA filed Critical Alfa Farmaceutici SpA
Priority to FR7215891A priority Critical patent/FR2182699A2/en
Publication of FR2182699A2 publication Critical patent/FR2182699A2/en
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P37/00—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin
    • C12P37/04—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin by acylation of the substituent in the 6 position
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P37/00—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin
    • C12P37/06—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin by desacylation of the substituent in the 6 position

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Title cpds. of formula (I) are prepd. by enzymatic dephylacetylation in accordance with parent patent using, as source of penicillin-acylase, either Escherichia coli resistant to 2000 gamma/ml. phenylacetic acid, or Aerobacter aerogenes, resistant to 2500 gamma/ml. phenylacetic acid (where n = alpha-amino or alpha-carboxybenzyl, 2- or 3-thienylmethyl, 2- or 3- thienylaminomethyl, an isoxazole - R1 = phenyl, 2-Cl or 2,6-diCl-phenyl; R2 = aryl, aryloxy, arylmercapto, opt. substd. by halogens; R3 = H, alkyl, alkyloxy, amino, mono- or di-alkylamino, carboxyalkyl, carboxymethylacetoxy, carboxybenzyl, or R2 and R3 = cycloaliphatic, R4 = H or when R2 and R3 = cycloaliphatic, H may also represent amino, mono or di-alkylamino.
FR7215891A 1972-05-04 1972-05-04 Semi-synthetic penicillins prepn - by enzymatic hydrolysis using escherichia-a coli or aerobacter aerogenes Pending FR2182699A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR7215891A FR2182699A2 (en) 1972-05-04 1972-05-04 Semi-synthetic penicillins prepn - by enzymatic hydrolysis using escherichia-a coli or aerobacter aerogenes

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7215891A FR2182699A2 (en) 1972-05-04 1972-05-04 Semi-synthetic penicillins prepn - by enzymatic hydrolysis using escherichia-a coli or aerobacter aerogenes

Publications (1)

Publication Number Publication Date
FR2182699A2 true FR2182699A2 (en) 1973-12-14

Family

ID=9097999

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7215891A Pending FR2182699A2 (en) 1972-05-04 1972-05-04 Semi-synthetic penicillins prepn - by enzymatic hydrolysis using escherichia-a coli or aerobacter aerogenes

Country Status (1)

Country Link
FR (1) FR2182699A2 (en)

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