FR2181763A2 - Pregnano-oxazepine compounds - with cardiovascular activity - Google Patents
Pregnano-oxazepine compounds - with cardiovascular activityInfo
- Publication number
- FR2181763A2 FR2181763A2 FR7306701A FR7306701A FR2181763A2 FR 2181763 A2 FR2181763 A2 FR 2181763A2 FR 7306701 A FR7306701 A FR 7306701A FR 7306701 A FR7306701 A FR 7306701A FR 2181763 A2 FR2181763 A2 FR 2181763A2
- Authority
- FR
- France
- Prior art keywords
- acyl
- cpds
- useful
- pregnano
- gps
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000005792 cardiovascular activity Effects 0.000 title 1
- 125000002252 acyl group Chemical group 0.000 abstract 5
- ISNYUQWBWALXEY-UHFFFAOYSA-N Batrachotoxin Natural products C=1CC2(C3=CCC4C5(C)CCC(C4)(O)OC53C(O)C3)OCCN(C)CC32C=1C(C)OC(=O)C=1C(C)=CNC=1C ISNYUQWBWALXEY-UHFFFAOYSA-N 0.000 abstract 1
- 206010019280 Heart failures Diseases 0.000 abstract 1
- 208000001953 Hypotension Diseases 0.000 abstract 1
- RAHZWNYVWXNFOC-UHFFFAOYSA-N Sulphur dioxide Chemical group O=S=O RAHZWNYVWXNFOC-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- ISNYUQWBWALXEY-ARGJWPBQSA-N batrachotoxin Chemical compound O([C@H](C)C=1[C@@]23CN(C)CCO[C@]3(C3=CC[C@H]4[C@]5(C)CC[C@](C4)(O)O[C@@]53[C@H](O)C2)CC=1)C(=O)C=1C(C)=CNC=1C ISNYUQWBWALXEY-ARGJWPBQSA-N 0.000 abstract 1
- 230000017531 blood circulation Effects 0.000 abstract 1
- 239000002934 diuretic Substances 0.000 abstract 1
- 230000001882 diuretic effect Effects 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 208000021822 hypotensive Diseases 0.000 abstract 1
- 230000001077 hypotensive effect Effects 0.000 abstract 1
- 230000000956 myotropic effect Effects 0.000 abstract 1
- 230000009090 positive inotropic effect Effects 0.000 abstract 1
- 150000003431 steroids Chemical class 0.000 abstract 1
- 125000001412 tetrahydropyranyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0036—Nitrogen-containing hetero ring
- C07J71/0057—Nitrogen and oxygen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of only two carbon atoms, e.g. pregnane derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
- C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
- C07J7/0065—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by an OH group free esterified or etherified
- C07J7/007—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by an OH group free esterified or etherified not substituted in position 17 alfa
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/001—Oxiranes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19722209747 DE2209747A1 (de) | 1972-02-25 | 1972-02-25 | Neue 18-nor-14beta-pregnano- eckige klammer auf 13.14-f eckige klammer zu -hexahydro-1'.4'-oxazepin-3'-one iii |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2181763A2 true FR2181763A2 (en) | 1973-12-07 |
| FR2181763B2 FR2181763B2 (enExample) | 1975-10-10 |
Family
ID=5837542
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR7306701A Granted FR2181763A2 (en) | 1972-02-25 | 1973-02-26 | Pregnano-oxazepine compounds - with cardiovascular activity |
Country Status (4)
| Country | Link |
|---|---|
| CH (1) | CH598287A5 (enExample) |
| DE (1) | DE2209747A1 (enExample) |
| FR (1) | FR2181763A2 (enExample) |
| NL (1) | NL7302672A (enExample) |
-
1972
- 1972-02-25 DE DE19722209747 patent/DE2209747A1/de not_active Withdrawn
-
1973
- 1973-02-19 CH CH238573A patent/CH598287A5/xx not_active IP Right Cessation
- 1973-02-26 NL NL7302672A patent/NL7302672A/xx unknown
- 1973-02-26 FR FR7306701A patent/FR2181763A2/fr active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| CH598287A5 (enExample) | 1978-04-28 |
| DE2209747A1 (de) | 1973-08-30 |
| FR2181763B2 (enExample) | 1975-10-10 |
| NL7302672A (enExample) | 1973-08-28 |
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