FR2156470A2 - 1-(3,3-diphenyl-1-propyl)-4-aryl-piperidines - as analgesics spasmolytic and anti-tussive agents - Google Patents
1-(3,3-diphenyl-1-propyl)-4-aryl-piperidines - as analgesics spasmolytic and anti-tussive agentsInfo
- Publication number
- FR2156470A2 FR2156470A2 FR7137872A FR7137872A FR2156470A2 FR 2156470 A2 FR2156470 A2 FR 2156470A2 FR 7137872 A FR7137872 A FR 7137872A FR 7137872 A FR7137872 A FR 7137872A FR 2156470 A2 FR2156470 A2 FR 2156470A2
- Authority
- FR
- France
- Prior art keywords
- aryl
- diphenyl
- halide
- spasmolytic
- piperidines
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229940035676 analgesics Drugs 0.000 title 1
- 239000000730 antalgic agent Substances 0.000 title 1
- 239000003434 antitussive agent Substances 0.000 title 1
- 229940124584 antitussives Drugs 0.000 title 1
- 239000000812 cholinergic antagonist Substances 0.000 title 1
- 230000002048 spasmolytic effect Effects 0.000 title 1
- -1 3,3-diphenylpropyl halide Chemical class 0.000 abstract 3
- 125000003118 aryl group Chemical group 0.000 abstract 3
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 abstract 2
- CBOIHMRHGLHBPB-UHFFFAOYSA-N hydroxymethyl Chemical compound O[CH2] CBOIHMRHGLHBPB-UHFFFAOYSA-N 0.000 abstract 2
- BYNJCCMGUBTMJZ-UHFFFAOYSA-N 3,3-diphenylpropanal Chemical compound C=1C=CC=CC=1C(CC=O)C1=CC=CC=C1 BYNJCCMGUBTMJZ-UHFFFAOYSA-N 0.000 abstract 1
- KQKFQBTWXOGINC-UHFFFAOYSA-N 4-phenylpiperidin-4-ol Chemical compound C=1C=CC=CC=1C1(O)CCNCC1 KQKFQBTWXOGINC-UHFFFAOYSA-N 0.000 abstract 1
- 101100496169 Arabidopsis thaliana CLH1 gene Proteins 0.000 abstract 1
- 101100044057 Mesocricetus auratus SYCP3 gene Proteins 0.000 abstract 1
- 101100080600 Schizosaccharomyces pombe (strain 972 / ATCC 24843) nse6 gene Proteins 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 230000002862 amidating effect Effects 0.000 abstract 1
- 101150111293 cor-1 gene Proteins 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000000896 monocarboxylic acid group Chemical group 0.000 abstract 1
- 125000003386 piperidinyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/30—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
- C07D211/32—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/52—Oxygen atoms attached in position 4 having an aryl radical as the second substituent in position 4
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (10)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7137872A FR2156470A2 (en) | 1971-10-21 | 1971-10-21 | 1-(3,3-diphenyl-1-propyl)-4-aryl-piperidines - as analgesics spasmolytic and anti-tussive agents |
| BE775611A BE775611A (fr) | 1970-11-24 | 1971-11-19 | Derives de la (diphenyl-3,3 propyl-1)-1 piperidine, leur preparation etles medicaments qui en contiennent |
| CH1695771A CH547283A (fr) | 1970-11-24 | 1971-11-22 | Procede de preparation de nouveaux derives de la (diphenyl-3,3 propyl-1)-1 piperidine. |
| OA54413A OA03922A (fr) | 1970-11-24 | 1971-11-22 | Procédé de préparation de nouveaux dérivés de la (diphényl-3,3 propyl-1)-1 pipéridine. |
| CA128,338A CA949560A (en) | 1970-11-24 | 1971-11-23 | Piperidine derivatives |
| DE19712158077 DE2158077A1 (de) | 1970-11-24 | 1971-11-23 | Derivate des l-(3,3-Diphenyl-propyl)piperidins, ihre Herstellung und diese enthaltende Arzneimittel |
| NL7116150A NL7116150A (online.php) | 1970-11-24 | 1971-11-24 | |
| ES397297A ES397297A1 (es) | 1970-11-24 | 1971-11-24 | Procedimiento para la obtencion de derivados de la piperi- dina. |
| JP46093763A JPS4849772A (online.php) | 1970-11-24 | 1971-11-24 | |
| AU36146/71A AU3614671A (en) | 1970-11-24 | 1971-11-25 | New piperidine derivatives |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7137872A FR2156470A2 (en) | 1971-10-21 | 1971-10-21 | 1-(3,3-diphenyl-1-propyl)-4-aryl-piperidines - as analgesics spasmolytic and anti-tussive agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2156470A2 true FR2156470A2 (en) | 1973-06-01 |
| FR2156470B2 FR2156470B2 (online.php) | 1974-11-15 |
Family
ID=9084709
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR7137872A Granted FR2156470A2 (en) | 1970-11-24 | 1971-10-21 | 1-(3,3-diphenyl-1-propyl)-4-aryl-piperidines - as analgesics spasmolytic and anti-tussive agents |
Country Status (2)
| Country | Link |
|---|---|
| AU (1) | AU3614671A (online.php) |
| FR (1) | FR2156470A2 (online.php) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1991009845A1 (en) * | 1989-12-21 | 1991-07-11 | Aktiebolaget Astra | Substituted 4-phenyl-4-piperidinecarboxamides with both local anaesthetic and analgesic effect as well as processes for their preparation |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB856587A (en) * | 1956-04-02 | 1960-12-21 | Sterling Drug Inc | Substituted piperidines |
| CH470387A (de) * | 1964-12-03 | 1969-03-31 | Hoechst Ag | Verfahren zur Herstellung von Piperidin-derivaten und deren Salzen |
-
1971
- 1971-10-21 FR FR7137872A patent/FR2156470A2/fr active Granted
- 1971-11-25 AU AU36146/71A patent/AU3614671A/en not_active Expired
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB856587A (en) * | 1956-04-02 | 1960-12-21 | Sterling Drug Inc | Substituted piperidines |
| CH470387A (de) * | 1964-12-03 | 1969-03-31 | Hoechst Ag | Verfahren zur Herstellung von Piperidin-derivaten und deren Salzen |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1991009845A1 (en) * | 1989-12-21 | 1991-07-11 | Aktiebolaget Astra | Substituted 4-phenyl-4-piperidinecarboxamides with both local anaesthetic and analgesic effect as well as processes for their preparation |
| US5227389A (en) * | 1989-12-21 | 1993-07-13 | Aktiebolaget Astra | Substituted 4-phenyl-4-piperidinecarboxamides with both local anaesthetic and analgesic effect as well as processes for their preparation |
| LT4005B (en) | 1989-12-21 | 1996-07-25 | Astra Ab | Substituted 4-phenyl-4-piperidinecarboxamides with both local anaesthetic and analgesic effect as well as processes for their preparation |
| CN1037841C (zh) * | 1989-12-21 | 1998-03-25 | 阿斯特拉公司 | 具有局部麻醉和止痛作用的取代4－苯基－4－呱啶甲酰胺的制备方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| FR2156470B2 (online.php) | 1974-11-15 |
| AU3614671A (en) | 1973-05-31 |
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