FR2115030A1 - 1-(3,3-diphenyl-1-propyl)-4-aryl-piperidines - as analgesics spasmolytic and anti-tussive agents - Google Patents

1-(3,3-diphenyl-1-propyl)-4-aryl-piperidines - as analgesics spasmolytic and anti-tussive agents

Info

Publication number
FR2115030A1
FR2115030A1 FR7042146A FR7042146A FR2115030A1 FR 2115030 A1 FR2115030 A1 FR 2115030A1 FR 7042146 A FR7042146 A FR 7042146A FR 7042146 A FR7042146 A FR 7042146A FR 2115030 A1 FR2115030 A1 FR 2115030A1
Authority
FR
France
Prior art keywords
aryl
diphenyl
halide
spasmolytic
piperidines
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7042146A
Other languages
French (fr)
Other versions
FR2115030B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Synthelabo SA
Original Assignee
Synthelabo SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synthelabo SA filed Critical Synthelabo SA
Priority to FR7042146A priority Critical patent/FR2115030A1/en
Priority to BE775611A priority patent/BE775611A/en
Priority to CH1695771A priority patent/CH547283A/en
Priority to OA54413A priority patent/OA03922A/en
Priority to CA128,338A priority patent/CA949560A/en
Priority to DE19712158077 priority patent/DE2158077A1/en
Priority to ES397297A priority patent/ES397297A1/en
Priority to ZA717906A priority patent/ZA717906B/en
Priority to NL7116150A priority patent/NL7116150A/xx
Priority to JP46093763A priority patent/JPS4849772A/ja
Publication of FR2115030A1 publication Critical patent/FR2115030A1/en
Application granted granted Critical
Publication of FR2115030B1 publication Critical patent/FR2115030B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/52—Oxygen atoms attached in position 4 having an aryl radical as the second substituent in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/30—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
    • C07D211/32—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Cpds. (I) and their salts (where Aryl is Ph and R is OCOR, CH2OH, CH2OCOR1, COR1, CN, CONR1R2 or OCOOR1, or is m-trifluoro-methylphenyl and R is OH or OCOR1; R1 is 1-4C alkyl; R2 is H, Me or Et or N(R2)2 is an N-contg. heterocyclic ring) are prepd. by a variety of methods involving condensing a 3,3-diphenylpropyl halide and a piperidine and opt. introducing R1 or Aryl, R into the piperidine ring or converting R=OH into R=acylated OH or amidating R=COOH, or reducing R-COOAlkyl to R=CH2OH, or replacing the 3,3-diphenylpropyl halide by 3,3-diphenyl-propionaldehyde or the propionyl halide and opt. reducing the product. Thus (I, Aryl=Ph and R=OCOEt) is prepd. from Ph2CH.CH2CH2Cl and 4-phenyl-4-piperidinol and acylating the product.
FR7042146A 1970-11-24 1970-11-24 1-(3,3-diphenyl-1-propyl)-4-aryl-piperidines - as analgesics spasmolytic and anti-tussive agents Granted FR2115030A1 (en)

Priority Applications (10)

Application Number Priority Date Filing Date Title
FR7042146A FR2115030A1 (en) 1970-11-24 1970-11-24 1-(3,3-diphenyl-1-propyl)-4-aryl-piperidines - as analgesics spasmolytic and anti-tussive agents
BE775611A BE775611A (en) 1970-11-24 1971-11-19 DERIVATIVES OF (DIPHENYL-3,3 PROPYL-1) -1 PIPERIDINE, THEIR PREPARATION AND THE MEDICINAL PRODUCTS CONTAINING IT
OA54413A OA03922A (en) 1970-11-24 1971-11-22 Process for the preparation of novel derivatives of (diphenyl-3,3 propyl-1) -1 piperidine.
CH1695771A CH547283A (en) 1970-11-24 1971-11-22 PROCESS FOR THE PREPARATION OF NEW DERIVATIVES OF (DIPHENYL-3,3 PROPYL-1) -1 PIPERIDINE.
CA128,338A CA949560A (en) 1970-11-24 1971-11-23 Piperidine derivatives
DE19712158077 DE2158077A1 (en) 1970-11-24 1971-11-23 1-(3,3-diphenyl-1-propyl)-4-aryl-piperidines - as analgesics spasmolytic and anti-tussive agents
ES397297A ES397297A1 (en) 1970-11-24 1971-11-24 1-(3,3-diphenyl-1-propyl)-4-aryl-piperidines - as analgesics spasmolytic and anti-tussive agents
ZA717906A ZA717906B (en) 1970-11-24 1971-11-24 New piperidine derivatives
NL7116150A NL7116150A (en) 1970-11-24 1971-11-24
JP46093763A JPS4849772A (en) 1970-11-24 1971-11-24

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7042146A FR2115030A1 (en) 1970-11-24 1970-11-24 1-(3,3-diphenyl-1-propyl)-4-aryl-piperidines - as analgesics spasmolytic and anti-tussive agents

Publications (2)

Publication Number Publication Date
FR2115030A1 true FR2115030A1 (en) 1972-07-07
FR2115030B1 FR2115030B1 (en) 1974-03-22

Family

ID=9064623

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7042146A Granted FR2115030A1 (en) 1970-11-24 1970-11-24 1-(3,3-diphenyl-1-propyl)-4-aryl-piperidines - as analgesics spasmolytic and anti-tussive agents

Country Status (2)

Country Link
FR (1) FR2115030A1 (en)
ZA (1) ZA717906B (en)

Also Published As

Publication number Publication date
FR2115030B1 (en) 1974-03-22
ZA717906B (en) 1972-08-30

Similar Documents

Publication Publication Date Title
ES397297A1 (en) 1-(3,3-diphenyl-1-propyl)-4-aryl-piperidines - as analgesics spasmolytic and anti-tussive agents
JPS51149296A (en) Cephems or penams and their preparation
ES8604571A1 (en) Indole-3-carboxamide derivatives.
GB1467927A (en) Derivatives of tyrosine having a pharmaceutical activity on smooth muscles
ES434726A1 (en) New hydroaromatic compounds
FR2156470A2 (en) 1-(3,3-diphenyl-1-propyl)-4-aryl-piperidines - as analgesics spasmolytic and anti-tussive agents
FR2115030A1 (en) 1-(3,3-diphenyl-1-propyl)-4-aryl-piperidines - as analgesics spasmolytic and anti-tussive agents
AR240910A2 (en) A method for oxidizing alkyl groups to carboxylic acids under basic conditions
BE783712A (en) DISMUTATION OF ALKALINE METAL SALTS OF AROMATIC CARBOXYLIC ACIDS
SU646070A1 (en) Power plant for feeding water to boilers
BE834324A (en) METHOD AND DEVICE FOR IMPROVING THE EFFICIENCY OF A MOTORCOMPRESSOR UNIT
IE34401B1 (en) New 21,21-dichloro-steroids
FR2191894A1 (en) Vincamine and apovincaminic esters and N-oxides - cerebrovascular agents prepd by transesterification of methyl esters and opt oxidn
FR2068402A1 (en) Medicaments contg 2-phenyl-benzimidazoles
JPS5247988A (en) Method of producing l-tartaric acid
BE757772A (en) DEVICE FOR AUTOMATIC GENERATION OF A RHYTHM
SE323359B (en)
JPS5216138A (en) Magnetic babble cassette memory
SU64108A1 (en) Method of protecting light metals from the corrosive effect of antifreeze
FR2215208A1 (en) Basic esters of 2-phenyl -4 - alkyl-4-hexanoic acids - useful as spasmolytics
IE810107L (en) 17-aminosteroids
FR2000204A1 (en) 2,3,4,4a,5,6-Hexahydro-1H-pyrazino(1,2-a)-quinolines (I) and their pharmaceutically acceptable acid addn. salts. where R' = H, alkyl, HO-alkyl, cycloalkyl, aral
FR2092682A1 (en) 1-aminocarbonylmethyl-4-ureidopiperazines - with hypotensive bronchodilator, diuretic analgesic, antiinflammatory activity
HUT43841A (en) Process for production of derivatives quinoline carbonic acid
CA926109A (en) Method of and dosage concentration utilizing piperidine as a condensate corrosion inhibitor

Legal Events

Date Code Title Description
ST Notification of lapse