FR2148363A1 - Dihydrobenzopyran derivs - as cardiac and respiratory analeptic agents and hypo tensive agents - Google Patents
Dihydrobenzopyran derivs - as cardiac and respiratory analeptic agents and hypo tensive agentsInfo
- Publication number
- FR2148363A1 FR2148363A1 FR7129318A FR7129318A FR2148363A1 FR 2148363 A1 FR2148363 A1 FR 2148363A1 FR 7129318 A FR7129318 A FR 7129318A FR 7129318 A FR7129318 A FR 7129318A FR 2148363 A1 FR2148363 A1 FR 2148363A1
- Authority
- FR
- France
- Prior art keywords
- agents
- substd
- opt
- cardiac
- flavonyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002220 antihypertensive agent Substances 0.000 title abstract 2
- 230000000747 cardiac effect Effects 0.000 title abstract 2
- 239000003169 respiratory stimulant agent Substances 0.000 title abstract 2
- 239000002371 cardiac agent Substances 0.000 title 1
- VZWXIQHBIQLMPN-UHFFFAOYSA-N chromane Chemical compound C1=CC=C2CCCOC2=C1 VZWXIQHBIQLMPN-UHFFFAOYSA-N 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 abstract 3
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 2
- UVKAJPXGNFZMFH-UHFFFAOYSA-N 2-[(2-phenyl-2,3-dihydrochromen-4-ylidene)amino]guanidine Chemical compound O1C2=CC=CC=C2C(=NN=C(N)N)CC1C1=CC=CC=C1 UVKAJPXGNFZMFH-UHFFFAOYSA-N 0.000 abstract 1
- YGNFQPIFRQQGBM-UHFFFAOYSA-N 2-[2-(2-hydroxyphenyl)-3-methyl-4-oxochromen-7-yl]oxyacetic acid Chemical compound CC1=C(OC2=CC(=CC=C2C1=O)OCC(=O)O)C1=C(C=CC=C1)O YGNFQPIFRQQGBM-UHFFFAOYSA-N 0.000 abstract 1
- 125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 abstract 1
- 125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 abstract 1
- 125000000339 4-pyridyl group Chemical group N1=C([H])C([H])=C([*])C([H])=C1[H] 0.000 abstract 1
- 101100079984 Caenorhabditis elegans nhr-9 gene Proteins 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- CQDNSNAZQMTUPZ-UHFFFAOYSA-N ethyl 2-[2-(2,4-dichlorophenyl)-3-methyl-4-oxochromen-7-yl]oxyacetate Chemical compound ClC1=C(C=2OC3=CC(=CC=C3C(C2C)=O)OCC(=O)OCC)C=CC(=C1)Cl CQDNSNAZQMTUPZ-UHFFFAOYSA-N 0.000 abstract 1
- NCNHBVWLRGRDHA-UHFFFAOYSA-N ethyl 2-[4-oxo-2-(2,4,5-trimethoxyphenyl)chromen-7-yl]oxyacetate Chemical compound COC1=C(C=2OC3=CC(=CC=C3C(C2)=O)OCC(=O)OCC)C=C(C(=C1)OC)OC NCNHBVWLRGRDHA-UHFFFAOYSA-N 0.000 abstract 1
- 125000002541 furyl group Chemical group 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- -1 methylenedioxy Chemical group 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 238000007911 parenteral administration Methods 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001544 thienyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
- C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
- C07D311/28—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only
- C07D311/32—2,3-Dihydro derivatives, e.g. flavanones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C07D311/68—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with nitrogen atoms directly attached in position 4
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Priority Applications (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7129318A FR2148363A1 (en) | 1971-08-11 | 1971-08-11 | Dihydrobenzopyran derivs - as cardiac and respiratory analeptic agents and hypo tensive agents |
| BE786970A BE786970A (fr) | 1971-08-11 | 1972-07-31 | Nouveaux derives dihydrobenzopyraniques |
| DE19722239033 DE2239033A1 (de) | 1971-08-11 | 1972-08-08 | Dihydrobenzopyranderivate und verfahren zur herstellung derselben |
| LU65877D LU65877A1 (enExample) | 1971-08-11 | 1972-08-09 | |
| NL7210950A NL7210950A (enExample) | 1971-08-11 | 1972-08-10 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7129318A FR2148363A1 (en) | 1971-08-11 | 1971-08-11 | Dihydrobenzopyran derivs - as cardiac and respiratory analeptic agents and hypo tensive agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2148363A1 true FR2148363A1 (en) | 1973-03-23 |
| FR2148363B1 FR2148363B1 (enExample) | 1974-09-06 |
Family
ID=9081723
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR7129318A Granted FR2148363A1 (en) | 1971-08-11 | 1971-08-11 | Dihydrobenzopyran derivs - as cardiac and respiratory analeptic agents and hypo tensive agents |
Country Status (5)
| Country | Link |
|---|---|
| BE (1) | BE786970A (enExample) |
| DE (1) | DE2239033A1 (enExample) |
| FR (1) | FR2148363A1 (enExample) |
| LU (1) | LU65877A1 (enExample) |
| NL (1) | NL7210950A (enExample) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0025600A1 (en) * | 1979-09-13 | 1981-03-25 | The Wellcome Foundation Limited | 2-Pyridyl chromans and pharmaceutical compositions containing them |
| EP0415566A1 (en) * | 1989-08-03 | 1991-03-06 | SHIONOGI SEIYAKU KABUSHIKI KAISHA trading under the name of SHIONOGI & CO. LTD. | Heterocyclic compounds, processes for producing them and pharmaceutical compositions comprising them |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4782176A (en) * | 1983-01-24 | 1988-11-01 | Hoffmann-La Roche Inc. | Phenoxycarboxylic acids |
| US5268388A (en) * | 1988-12-27 | 1993-12-07 | E. I. Du Pont De Nemours And Company | Substituted semicarbazone arthropodicides |
-
1971
- 1971-08-11 FR FR7129318A patent/FR2148363A1/fr active Granted
-
1972
- 1972-07-31 BE BE786970A patent/BE786970A/xx unknown
- 1972-08-08 DE DE19722239033 patent/DE2239033A1/de active Pending
- 1972-08-09 LU LU65877D patent/LU65877A1/xx unknown
- 1972-08-10 NL NL7210950A patent/NL7210950A/xx unknown
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0025600A1 (en) * | 1979-09-13 | 1981-03-25 | The Wellcome Foundation Limited | 2-Pyridyl chromans and pharmaceutical compositions containing them |
| US4563468A (en) * | 1979-09-13 | 1986-01-07 | Burroughs Wellcome Co. | Chemotherapeutic agents |
| EP0415566A1 (en) * | 1989-08-03 | 1991-03-06 | SHIONOGI SEIYAKU KABUSHIKI KAISHA trading under the name of SHIONOGI & CO. LTD. | Heterocyclic compounds, processes for producing them and pharmaceutical compositions comprising them |
| US5268386A (en) * | 1989-08-03 | 1993-12-07 | Shionogi & Co., Ltd. | Certain 3,4-dihydro 4-oxospiro [2H-1 benzopyrans] useful for treating hyperuricemia |
Also Published As
| Publication number | Publication date |
|---|---|
| BE786970A (fr) | 1972-11-16 |
| NL7210950A (enExample) | 1973-02-13 |
| LU65877A1 (enExample) | 1973-01-15 |
| FR2148363B1 (enExample) | 1974-09-06 |
| DE2239033A1 (de) | 1973-02-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ST | Notification of lapse |