FR2126455A1 - Prostanoic acid derivs - with luteolytic, hypotensive and bronchodilator activity - Google Patents
Prostanoic acid derivs - with luteolytic, hypotensive and bronchodilator activityInfo
- Publication number
- FR2126455A1 FR2126455A1 FR7206610A FR7206610A FR2126455A1 FR 2126455 A1 FR2126455 A1 FR 2126455A1 FR 7206610 A FR7206610 A FR 7206610A FR 7206610 A FR7206610 A FR 7206610A FR 2126455 A1 FR2126455 A1 FR 2126455A1
- Authority
- FR
- France
- Prior art keywords
- luteolytic
- hypotensive
- substd
- straight chain
- chain alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 208000001953 Hypotension Diseases 0.000 title 1
- 229940124630 bronchodilator Drugs 0.000 title 1
- 230000000694 effects Effects 0.000 title 1
- 208000021822 hypotensive Diseases 0.000 title 1
- 230000001077 hypotensive effect Effects 0.000 title 1
- 230000003529 luteolytic effect Effects 0.000 title 1
- WGJJROVFWIXTPA-OALUTQOASA-N prostanoic acid Chemical compound CCCCCCCC[C@H]1CCC[C@@H]1CCCCCCC(O)=O WGJJROVFWIXTPA-OALUTQOASA-N 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000006041 3-hexenyl group Chemical group 0.000 abstract 1
- 125000006042 4-hexenyl group Chemical group 0.000 abstract 1
- 125000006043 5-hexenyl group Chemical group 0.000 abstract 1
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 abstract 1
- 239000005977 Ethylene Substances 0.000 abstract 1
- 229930194542 Keto Natural products 0.000 abstract 1
- PQGAHNJECSVDEI-UHFFFAOYSA-N [CH2]CCCCC Chemical compound [CH2]CCCCC PQGAHNJECSVDEI-UHFFFAOYSA-N 0.000 abstract 1
- 125000004423 acyloxy group Chemical group 0.000 abstract 1
- 125000005678 ethenylene group Chemical group [H]C([*:1])=C([H])[*:2] 0.000 abstract 1
- 125000000219 ethylidene group Chemical group [H]C(=[*])C([H])([H])[H] 0.000 abstract 1
- 125000000468 ketone group Chemical group 0.000 abstract 1
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 abstract 1
- 125000001280 n-hexyl group Chemical group C(CCCCC)* 0.000 abstract 1
- 125000000740 n-pentyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 abstract 1
- 125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 abstract 1
- 229920002554 vinyl polymer Polymers 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
- C07D307/935—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C53/00—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen
- C07C53/15—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen containing halogen
- C07C53/19—Acids containing three or more carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/10—Oxygen atoms
- C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
- C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4006—Esters of acyclic acids which can have further substituents on alkyl
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/54—Quaternary phosphonium compounds
- C07F9/5407—Acyclic saturated phosphonium compounds
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
The novel title cpds. are of formula (in which R1 is OH, 1-6C alkoxy; or 2-3C alkoxy substd. by a beta-dialkylamino or gamma-dialkylamino radical, or R1 is beta-or gamma-pyrrolidino, piperidino or morpholino, R2 is OH or 1-4C alkanoyloxy and R3 is H, or R2 and R3 together form a keto gp; R4 is n-pentyl, n-hexyl (opt. substd. by a 1-4C straight chain alkyl in one of 1-5 posns. or CH3, C2H5, -CH2-, ethylidene or vinyl, or a CH3 and -CH2-, or 2 CH3 gps. in 6 posn. of the hexyl radical) or R4 is 3-, 4- or 5-hexenyl (opt. substd. by a 1-4C straight chain alkyl in one of 1-6 posns. 1 or 2 of R5, R6, R7, R8 and R9 are 1-4C straight chain alkyl and the others are H; and A is ethylene or vinylene) including salts of cpds. in which R1 is OH.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB554471 | 1971-02-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| FR2126455A1 true FR2126455A1 (en) | 1972-10-06 |
Family
ID=9798160
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR7206610A Withdrawn FR2126455A1 (en) | 1971-02-26 | 1972-02-25 | Prostanoic acid derivs - with luteolytic, hypotensive and bronchodilator activity |
Country Status (6)
| Country | Link |
|---|---|
| BE (1) | BE779898A (en) |
| BR (1) | BR7201023D0 (en) |
| DE (1) | DE2209039A1 (en) |
| FR (1) | FR2126455A1 (en) |
| NL (1) | NL7202493A (en) |
| ZA (1) | ZA72713B (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS4949963A (en) * | 1972-09-16 | 1974-05-15 | ||
| US3962312A (en) * | 1972-09-21 | 1976-06-08 | Ono Pharmaceutical Company | 9,11,15-Trihydroxy prost-5-enoic acid analogues |
| US4026927A (en) * | 1973-09-25 | 1977-05-31 | Yamanouchi Pharmaceutical Co., Ltd. | Novel prostaglandin derivatives |
-
1972
- 1972-02-03 ZA ZA720713A patent/ZA72713B/en unknown
- 1972-02-24 BR BR001023/72A patent/BR7201023D0/en unknown
- 1972-02-25 DE DE19722209039 patent/DE2209039A1/de active Pending
- 1972-02-25 NL NL7202493A patent/NL7202493A/xx unknown
- 1972-02-25 BE BE779898A patent/BE779898A/en unknown
- 1972-02-25 FR FR7206610A patent/FR2126455A1/en not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| DE2209039A1 (en) | 1972-09-07 |
| ZA72713B (en) | 1972-10-25 |
| NL7202493A (en) | 1972-08-29 |
| BE779898A (en) | 1972-08-25 |
| BR7201023D0 (en) | 1973-12-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RE | Withdrawal of published application |