FR2122325A2 - Polynucleic acid/polycationic compounds - for potentiating antiviral vaccines - Google Patents

Polynucleic acid/polycationic compounds - for potentiating antiviral vaccines

Info

Publication number
FR2122325A2
FR2122325A2 FR7101815A FR7101815A FR2122325A2 FR 2122325 A2 FR2122325 A2 FR 2122325A2 FR 7101815 A FR7101815 A FR 7101815A FR 7101815 A FR7101815 A FR 7101815A FR 2122325 A2 FR2122325 A2 FR 2122325A2
Authority
FR
France
Prior art keywords
polynucleic acid
potentiating
polycationic compounds
antiviral vaccines
vaccines
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7101815A
Other languages
French (fr)
Other versions
FR2122325B2 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MAES ROLAND BE
Original Assignee
MAES ROLAND BE
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by MAES ROLAND BE filed Critical MAES ROLAND BE
Priority to FR7101815A priority Critical patent/FR2122325A2/en
Publication of FR2122325A2 publication Critical patent/FR2122325A2/en
Application granted granted Critical
Publication of FR2122325B2 publication Critical patent/FR2122325B2/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Method of potentiating the antigenic response in man and animals, notably to vaccines which may contain additives by incorporating in the vaccine a reaction product of a polynucleic acid with a polycation. Suitable polycationic substances include diethylaminoethyl-dextran with a molecular weight of 103 to 108 pref. 104 to 107. Pref. polynucleic acids are polyinosinic (I), polycytidylic (c), polyuridylic (u) and polyadenylic acid (A).
FR7101815A 1971-01-20 1971-01-20 Polynucleic acid/polycationic compounds - for potentiating antiviral vaccines Granted FR2122325A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR7101815A FR2122325A2 (en) 1971-01-20 1971-01-20 Polynucleic acid/polycationic compounds - for potentiating antiviral vaccines

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7101815A FR2122325A2 (en) 1971-01-20 1971-01-20 Polynucleic acid/polycationic compounds - for potentiating antiviral vaccines

Publications (2)

Publication Number Publication Date
FR2122325A2 true FR2122325A2 (en) 1972-09-01
FR2122325B2 FR2122325B2 (en) 1974-08-23

Family

ID=9070579

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7101815A Granted FR2122325A2 (en) 1971-01-20 1971-01-20 Polynucleic acid/polycationic compounds - for potentiating antiviral vaccines

Country Status (1)

Country Link
FR (1) FR2122325A2 (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2328479A1 (en) * 1975-10-22 1977-05-20 Beecham Group Ltd Antiviral ionic complex of linear polyarginine - and natural double-chain ribonucleic acid or its derivative
EP0009498A1 (en) * 1978-01-16 1980-04-16 Univ Boston Effecting cellular uptake of molecules.
WO1996021036A2 (en) * 1994-12-30 1996-07-11 Chiron Viagene, Inc. Nucleic acid condensing agents with reduced immunogenicity

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2328479A1 (en) * 1975-10-22 1977-05-20 Beecham Group Ltd Antiviral ionic complex of linear polyarginine - and natural double-chain ribonucleic acid or its derivative
EP0009498A1 (en) * 1978-01-16 1980-04-16 Univ Boston Effecting cellular uptake of molecules.
EP0009498A4 (en) * 1978-01-16 1980-10-16 Univ Boston Effecting cellular uptake of molecules.
WO1996021036A2 (en) * 1994-12-30 1996-07-11 Chiron Viagene, Inc. Nucleic acid condensing agents with reduced immunogenicity
WO1996021036A3 (en) * 1994-12-30 1996-09-06 Viagene Inc Nucleic acid condensing agents with reduced immunogenicity

Also Published As

Publication number Publication date
FR2122325B2 (en) 1974-08-23

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Legal Events

Date Code Title Description
TP Transmission of property
GC Lien (pledge) constituted