FR2328479A1 - Antiviral ionic complex of linear polyarginine - and natural double-chain ribonucleic acid or its derivative - Google Patents

Antiviral ionic complex of linear polyarginine - and natural double-chain ribonucleic acid or its derivative

Info

Publication number
FR2328479A1
FR2328479A1 FR7532291A FR7532291A FR2328479A1 FR 2328479 A1 FR2328479 A1 FR 2328479A1 FR 7532291 A FR7532291 A FR 7532291A FR 7532291 A FR7532291 A FR 7532291A FR 2328479 A1 FR2328479 A1 FR 2328479A1
Authority
FR
France
Prior art keywords
ribonucleic acid
double chain
polyarginine
linear
antiviral
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7532291A
Other languages
French (fr)
Other versions
FR2328479B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beecham Group PLC
Original Assignee
Beecham Group PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Group PLC filed Critical Beecham Group PLC
Priority to FR7532291A priority Critical patent/FR2328479A1/en
Publication of FR2328479A1 publication Critical patent/FR2328479A1/en
Application granted granted Critical
Publication of FR2328479B1 publication Critical patent/FR2328479B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/785—Polymers containing nitrogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Antiviral substance comprises a mainly ionic complex in which the cationic part is a linear polyarginine having at least 5 arginine units and the anionic part is (a) a double chain ribonucleic acid polyanion, the double chain ribonucleic acid being of natural origin or (b) a polyanion of a double chain deriv. of a natural double chain ribonucleic acid. The complexes are antivirals with a broad spectrum of activity against both RNA and DNA viruses e.g. encephalomyocarditis (EMC) virus, Semlike Forest virus, foot and mouth disease virus and Herpes Simplex. At least part of their activity is due to induction of interferons in the cells of the host. The LD50 in mice of these complexes is less than the LD50 of the RNA alone.
FR7532291A 1975-10-22 1975-10-22 Antiviral ionic complex of linear polyarginine - and natural double-chain ribonucleic acid or its derivative Granted FR2328479A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR7532291A FR2328479A1 (en) 1975-10-22 1975-10-22 Antiviral ionic complex of linear polyarginine - and natural double-chain ribonucleic acid or its derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7532291A FR2328479A1 (en) 1975-10-22 1975-10-22 Antiviral ionic complex of linear polyarginine - and natural double-chain ribonucleic acid or its derivative

Publications (2)

Publication Number Publication Date
FR2328479A1 true FR2328479A1 (en) 1977-05-20
FR2328479B1 FR2328479B1 (en) 1979-09-14

Family

ID=9161502

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7532291A Granted FR2328479A1 (en) 1975-10-22 1975-10-22 Antiviral ionic complex of linear polyarginine - and natural double-chain ribonucleic acid or its derivative

Country Status (1)

Country Link
FR (1) FR2328479A1 (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2122325A2 (en) * 1971-01-20 1972-09-01 Maes Roland Polynucleic acid/polycationic compounds - for potentiating antiviral vaccines

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2122325A2 (en) * 1971-01-20 1972-09-01 Maes Roland Polynucleic acid/polycationic compounds - for potentiating antiviral vaccines

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
CHEMICAL ABSTRACTS, SUBSTANCES INDEX, VOLUME 76, PAGES 203, CS, 1972 *
CHEMICAL ABSTRACTS, VOLUME 76, 42925 E, 1972 *

Also Published As

Publication number Publication date
FR2328479B1 (en) 1979-09-14

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