FR2091913A1 - Grisorizine antibiotic - with antifungal and antibacterial properties - Google Patents
Grisorizine antibiotic - with antifungal and antibacterial propertiesInfo
- Publication number
- FR2091913A1 FR2091913A1 FR7014736A FR7014736A FR2091913A1 FR 2091913 A1 FR2091913 A1 FR 2091913A1 FR 7014736 A FR7014736 A FR 7014736A FR 7014736 A FR7014736 A FR 7014736A FR 2091913 A1 FR2091913 A1 FR 2091913A1
- Authority
- FR
- France
- Prior art keywords
- antifungal
- antibiotic
- grisorizine
- antibacterial properties
- antibacterial
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000000844 anti-bacterial effect Effects 0.000 title abstract 2
- 230000000843 anti-fungal effect Effects 0.000 title abstract 2
- 229940121375 antifungal agent Drugs 0.000 title abstract 2
- 230000003115 biocidal effect Effects 0.000 title abstract 2
- ZITSQIZMRMDQLE-RHQSYKMPSA-N 2-[(3s,6r)-6-[[(5r,6r,7r,9r)-2-[5-[(3s,5r)-5-[(2s,3s,5r,6s)-6-hydroxy-3,5,6-trimethyloxan-2-yl]-3-methyloxolan-2-yl]-5-methyloxolan-2-yl]-7-methoxy-2,4,6-trimethyl-1,10-dioxaspiro[4.5]decan-9-yl]methyl]-3-methyloxan-2-yl]propanoic acid Chemical compound C([C@@H]1C[C@H]([C@H]([C@]2(C(CC(C)(O2)C2OC(C)(CC2)C2[C@H](C[C@@H](O2)[C@@H]2[C@H](C[C@@H](C)[C@@](C)(O)O2)C)C)C)O1)C)OC)[C@H]1CC[C@H](C)C(C(C)C(O)=O)O1 ZITSQIZMRMDQLE-RHQSYKMPSA-N 0.000 abstract 1
- 235000014469 Bacillus subtilis Nutrition 0.000 abstract 1
- 241000222122 Candida albicans Species 0.000 abstract 1
- 241000282465 Canis Species 0.000 abstract 1
- ZITSQIZMRMDQLE-UHFFFAOYSA-N Grisorixin Natural products O1C2(C(CC(C)(O2)C2OC(C)(CC2)C2C(CC(O2)C2C(CC(C)C(C)(O)O2)C)C)C)C(C)C(OC)CC1CC1CCC(C)C(C(C)C(O)=O)O1 ZITSQIZMRMDQLE-UHFFFAOYSA-N 0.000 abstract 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 abstract 1
- 241001655322 Streptomycetales Species 0.000 abstract 1
- 229940095731 candida albicans Drugs 0.000 abstract 1
- 238000004587 chromatography analysis Methods 0.000 abstract 1
- 230000001085 cytostatic effect Effects 0.000 abstract 1
- 238000000855 fermentation Methods 0.000 abstract 1
- 230000004151 fermentation Effects 0.000 abstract 1
- 230000035784 germination Effects 0.000 abstract 1
- 230000002363 herbicidal effect Effects 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- DANUORFCFTYTSZ-SJSJOXFOSA-N nigericin Polymers C([C@@H]1C[C@H]([C@H]([C@]2([C@@H](C[C@](C)(O2)[C@@H]2O[C@@](C)(CC2)[C@H]2[C@H](C[C@@H](O2)[C@@H]2[C@H](C[C@@H](C)[C@](O)(CO)O2)C)C)C)O1)C)OC)[C@H]1CC[C@H](C)[C@H]([C@@H](C)C(O)=O)O1 DANUORFCFTYTSZ-SJSJOXFOSA-N 0.000 abstract 1
- 238000000746 purification Methods 0.000 abstract 1
- 239000000741 silica gel Substances 0.000 abstract 1
- 229910002027 silica gel Inorganic materials 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
- C12P17/181—Heterocyclic compounds containing oxygen atoms as the only ring heteroatoms in the condensed system, e.g. Salinomycin, Septamycin
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7014736A FR2091913A1 (en) | 1970-04-23 | 1970-04-23 | Grisorizine antibiotic - with antifungal and antibacterial properties |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7014736A FR2091913A1 (en) | 1970-04-23 | 1970-04-23 | Grisorizine antibiotic - with antifungal and antibacterial properties |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2091913A1 true FR2091913A1 (en) | 1971-01-21 |
| FR2091913B1 FR2091913B1 (enExample) | 1974-05-24 |
Family
ID=9054444
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR7014736A Granted FR2091913A1 (en) | 1970-04-23 | 1970-04-23 | Grisorizine antibiotic - with antifungal and antibacterial properties |
Country Status (1)
| Country | Link |
|---|---|
| FR (1) | FR2091913A1 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113527325A (zh) * | 2021-07-19 | 2021-10-22 | 中国科学院南海海洋研究所 | 一种尼日利亚菌素衍生物及其制备方法和在制备抗肿瘤药物中的应用 |
-
1970
- 1970-04-23 FR FR7014736A patent/FR2091913A1/fr active Granted
Non-Patent Citations (1)
| Title |
|---|
| NEANT * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113527325A (zh) * | 2021-07-19 | 2021-10-22 | 中国科学院南海海洋研究所 | 一种尼日利亚菌素衍生物及其制备方法和在制备抗肿瘤药物中的应用 |
| CN113527325B (zh) * | 2021-07-19 | 2023-11-17 | 中国科学院南海海洋研究所 | 一种尼日利亚菌素衍生物及其制备方法和在制备抗肿瘤药物中的应用 |
Also Published As
| Publication number | Publication date |
|---|---|
| FR2091913B1 (enExample) | 1974-05-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ST | Notification of lapse |